ESC Heart Fail:急性心衰患者瞳孔小,提示预后差!日本研究

2020-08-14 朱朱 中国循环杂志

在急性心衰患者中,看瞳孔大小有助于评估预后,瞳孔较小的患者全因死亡和因心衰再次住院的风险较高。中位随访1.9年期间,瞳孔较大的急性心衰患者全因死亡和因心衰再住院的风险分别降低28%和18%。

日本学者发现,在急性心衰患者中,看瞳孔大小有助于评估预后,瞳孔较小的患者全因死亡和因心衰再次住院的风险较高。分析显示,校正西雅图心衰评分、体重指数、B型利钠肽、估算肾小球滤过率等几个已知的预后因素后,中位随访1.9年期间,瞳孔较大的急性心衰患者全因死亡和因心衰再住院的风险分别降低28%和18%。

不论在窦性心律还是非窦性心律的急性心衰患者中,瞳孔较大者的预后均较好,两类患者因心衰再次住院和全因死亡的风险分别降低35%和24%。

将瞳孔大小加入到西雅图心衰评分中后,其对进行心衰患者全因死亡风险的预测价值明显提高。

研究者指出,用现有的方法很难定量评估非窦性心律急性心衰患者的自主神经功能,因此,用瞳孔大小作为评估急性心衰患者自主神经功能的替代指标,还能提供额外的预后预测信息,而且,瞳孔大小检查方法简单、无创。

研究者表示,目前尚不清楚瞳孔大小与急性心衰患者预后之间关联的具体机制,推测类似于变时功能不全,即瞳孔大小不能随急性心衰发作时自主神经功能变化而变化。

心衰发作时,典型的自主神经功能失调包括交感神经激活和副交感神经抑制,此时瞳孔本应扩大。

该研究为一项回顾性研究,一共纳入870例急性心衰住院患者,其平均年龄为67岁,入院后至少7天用瞳孔检测仪检查瞳孔大小,将瞳孔面积处于8.9~14.2 mm2者归为瞳孔较小组,瞳孔面积为19.2~26 mm2者为瞳孔较大组。

中位随访1.9年期间,131例患者死亡,328例患者因心衰再次住院。

原始出处:

Kohei Nozaki,Nobuaki Hamazaki,Shohei Yamamoto,et al. Prognostic value of pupil area for all‐cause mortality in patients with heart failure. ESC Heart Failure,First published:10 August 2020.doi: 10.1002/ehf2.12933.

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    2021-02-23 14660693m86(暂无昵称)

    学习是

    0

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    2020-12-19 kenny_lyt

    受教

    0

  3. 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    2020-12-12 shiyanqing

    思路特别

    0

  4. 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    2020-08-17 qingfengqishi5

    学习了,学习了

    0

  5. 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  6. 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    2020-08-16 zhaojie88
  7. 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  8. 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    2020-08-16 小几洁
  10. 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    2020-08-16 slcumt

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