JAHA:慢性肾脏疾病合并主动脉狭窄患者的预后研究

2019-01-28 MedSci MedSci原创

本研究的目的旨在评估主动脉狭窄(AS)伴慢性肾脏疾病(CKD)患者的长期生存率。本研究纳入了2005-2012年的839名AS合并CKD的患者(平均年龄78±9 岁,男性占51%),患者长期的全因死亡率和心源性死亡率是与CKD不合并AS的患者进行比较。最终,共有511 (61%)、252 (30%)和76 (9%)名患者发展为CKD3a期、3b期和4期,93%的患者患有高血压,28%的患者患有糖尿

本研究的目的旨在评估主动脉狭窄(AS)伴慢性肾脏疾病(CKD)患者的长期生存率。

本研究纳入了2005-2012年的839名AS合并CKD的患者(平均年龄78±9 岁,男性占51%),患者长期的全因死亡率和心源性死亡率是与CKD不合并AS的患者进行比较。最终,共有511 (61%)、252 (30%)和76 (9%)名患者发展为CKD3a期、3b期和4期,93%的患者患有高血压,28%的患者患有糖尿病,37%的患者患有冠心病。185名(22%)患者有轻度AS,355名(42%)患者有中度AS,299名(36%)患者有重度AS。在4.0±2.3年随访期间,与CKD不伴AS患者相比,CKD合并AS患者的全因死亡率和心源性死亡率均更高(P<0.001)。在AS合并CKD患者中,有156名(19%)患者接受了主动脉瓣置换术,454(54%)名患者死亡。低肾小球滤过率与高全因死亡率而非心源性死亡率呈相关性。另外,在接受了主动脉瓣置换术患者中,61%的患者在术后1年内的估计肾小球滤过率有所提高。

研究结果显示,在非透析慢性肾脏疾病患者中,合并主动脉狭窄会增加全因死亡风险和心源性死亡风险。

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    2019-01-30 zhaohui6731
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    2019-01-28 飛歌

    学习了很有用不错

    0

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