J INTERN MED:银屑病和银屑病关节炎患者冠状动脉疾病的患病率和严重程度如何?

2021-05-12 MedSci原创 MedSci原创

银屑病和PsA都与冠状动脉钙化发病率增加有关。银屑病患者严重钙化的发生率也有所增加。银屑病患者发生心血管事件和死亡的风险增加。

近日,内科学领域权威杂志Journal of Internal Medicine上发表一篇研究文章,该研究通过使用接受冠状动脉CT血管造影(CTA)的银屑病和银屑病关节炎(PsA)患者大型队列,旨在评估1)冠状动脉疾病的患病率和严重程度,2)心血管事件和死亡率的风险。

这是一项横断面研究,根据丹麦国家CTA登记处的数据,研究人员对46022名患者进行了随访。银屑病或PsA被作为暴露因素。以一组无银屑病、PsA或任何其他炎症性疾病的患者作为对照者。

该研究的横断面主要结局为冠状动脉钙评分(CACS)>0和CACS≥400,次要结局为梗阻性CAD。在随访期间,该研究的主要结局是心血管事件和全因死亡的复合结局。所有结具都根据常规心血管危险因素进行了调整。

研究人员确定了1356名银屑病患者和370名PsA患者。银屑病患者CACS>0、CACS≥400和阻塞性CAD的校正比值比(OR)分别为1.26(1.10‐1.46)、1.25(1.04‐1.50)和1.14(0.98‐1.33)。对于PsA患者,CACS>0的患者OR为1.28(1.00‐1.64)。研究人员发现银屑病患者主要结局粗略风险比(HR)为1.49(1.21‐1.85),调整后的HR为1.14(0.92‐1.41)。

在这一人群中,银屑病和PsA都与冠状动脉钙化发病率增加有关。银屑病患者严重钙化的发生率也有所增加。银屑病患者发生心血管事件和死亡的风险增加。

原始出处:

Andreas Bugge Tinggaard.et al.Prevalence and severity of coronary artery disease linked to prognosis in psoriasis and psoriatic arthritis patients: A multi‐centre cohort study.J INTERN MED.2021.https://doi.org/10.1111/joim.13311

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    2021-05-14 lmm397
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    2021-05-14 智慧医人
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    2021-05-13 ms6000001624652641

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