JAHA:年龄相关性黄斑变性与心衰风险之间的关联

2021-08-02 MedSci原创 MedSci原创

该研究提供的证据表明AMD与HF风险增加相关。需要进一步的分子和病​​理生理学研究来阐明AMD与HF之间相关性的潜在病理生理机制。

心力衰竭(HF)因其高发病率和死亡率已成为世界范围内主要的健康问题。最近,微血管系统在HF中的作用得到了更多的关注。年龄相关性黄斑变性(AMD)表现为区域性萎缩或新生血管形成。然而,关于AMD和HF之间关联的调查数据十分有限。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究的目的是在基于人群的大型男性和女性队列评估AMD与HF风险之间的关联。

2000年至2012年间,研究人员使用台湾国民健康保险研究数据库进行了嵌套病例对照研究。该研究招募了数据库中新诊断的HF病例(n=13721)和匹配的对照者(n=54884)。在HF诊断前至少1年有2次以上临床就诊并诊断为AMD的个体被确定为AMD患者。研究人员进行条件Logisitc回归以计算比值比和95%CI,来评估AMD与HF风险之间的关联。

AMD与HF风险

调整潜在混杂因素后,AMD与HF风险增加1.58倍相关(95%CI为1.16-1.87)(P<0.001)。这种显著关联在非渗出性和渗出性AMD亚组中都很明显。

由此可见,该研究提供的证据表明AMD与HF风险增加相关。需要进一步的分子和病​​理生理学研究来阐明AMD与HF之间相关性的潜在病理生理机制。

原始出处:

Chao‐Chien Chang.et al.Association Between Age‐Related Macular Degeneration and Risk of Heart Failure: A Population‐Based Nested Case‐Control Study.JAHA.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.020071

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    2021-08-11 眼科芳

    学习了

    0

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    2021-08-04 ms3000001999514966

    精神病理学物理实验机制

    0

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    2021-08-04 zhaohui6731
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    2021-08-04 huangdf
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    2021-08-04 muzishouyi

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