PARP抑制剂Lynparza在欧洲获得重大成功!同时获批治疗卵巢癌和前列腺癌

2020-11-09 MedSci原创 MedSci原创

阿斯利康和MSD的免疫疗法PARP抑制剂Lynparza(olaparib)在欧盟获得了两项新的批准。

阿斯利康和MSD的免疫疗法PARP抑制剂Lynparza(olaparib)在欧盟获得了两项新的批准。FDA在今年夏天也被批准,见:LYNPARZA(olaparib)联合贝伐单抗一线治疗HRD阳性晚期卵巢癌:已获FDA首肯,而具体结果2019年发表在NEJM上:NEJM:奥拉帕尼联合贝伐单抗一线治疗晚期卵巢癌

Treatment for Advanced Ovarian, Metastatic Breast, Pancreatic and Prostate  Cancers – LYNPARZA® (olaparib)

Lynparza的首个批准是与贝伐单抗联合用于HRD阳性晚期卵巢癌患者的一线维持治疗。

欧盟委员会的批准基于PAOLA-1 III期试验的结果,在该试验中,Lynparza联合贝伐单抗可使患者无疾病进展的中位时间延长至三年以上。

Ray-Coquard Image-2 ESMO 2019 News

图片来源:ESMO

Lynparza在欧盟获得的第二项批准,是用于治疗BRCA 1/2突变的去势抵抗性前列腺癌(mCRPC)患者。

PROfound III期试验结果支持了该批准,其中Lynparza的影像学无进展生存期(rPFS)与恩杂鲁胺(Enzalutamide)或阿比特龙(Abiraterone)相比增加了一倍多。

Olaparib delays progression in pretreated mCRPC patients with HRR gene  alterations | Latest news for Doctors, Nurses and Pharmacists | Oncology

图片来源:ESMO

原始出处:

http://www.pharmatimes.com/news/lynparza_scores_two_new_eu_approvals_1356198

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    2021-01-12 jklm09
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    2020-11-11 lishiwen
  4. [GetPortalCommentsPageByObjectIdResponse(id=1852534, encodeId=2e6f185253413, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Tue Jan 12 00:52:15 CST 2021, time=2021-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339363, encodeId=9ab11339363d3, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Wed Nov 11 05:52:15 CST 2020, time=2020-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621375, encodeId=6cf616213e56c, content=<a href='/topic/show?id=49b313e56ad' target=_blank style='color:#2F92EE;'>#PARP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13756, encryptionId=49b313e56ad, topicName=PARP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd4d20248280, createdName=lishiwen, createdTime=Wed Nov 11 05:52:15 CST 2020, time=2020-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898012, encodeId=d8d889801206, content=卵巢癌是女性肿瘤死亡之首,目前预后仍不佳。希望能有更多早筛、早治的方法!<a href='/topic/show?id=08f236865a8' target=_blank style='color:#2F92EE;'>#卵巢癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=175, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36865, encryptionId=08f236865a8, topicName=卵巢癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210607/9f00a0de660e4b36b77a9a5f7620d6bf/98c22b17ddf7446fa7b9a618fabcb9f7.jpg, createdBy=a8fb2299762, createdName=Psycho.Dr Du, createdTime=Mon Nov 09 18:06:37 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040886, encodeId=390f1040886ae, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Nov 09 17:52:15 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897979, encodeId=5aee89e97924, content=不错的学习资料, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0e85433204, createdName=Sarah2020cpp, createdTime=Mon Nov 09 15:27:24 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897969, encodeId=345889e9697a, content=<a href='/topic/show?id=41f54454653' target=_blank style='color:#2F92EE;'>#奥拉帕利#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44546, encryptionId=41f54454653, topicName=奥拉帕利)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Nov 09 15:05:47 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897966, encodeId=041e89e966b1, content=<a href='/topic/show?id=82ba111646a' target=_blank style='color:#2F92EE;'>#Lynparza#</a>与<a href='/topic/show?id=aeef922031b' target=_blank style='color:#2F92EE;'>#贝伐单抗#</a>联合用于HRD阳性晚期<a href='/topic/show?id=08f236865a8' target=_blank style='color:#2F92EE;'>#卵巢癌#</a>患者的一线维持治疗,能提升3倍,很吓人!!PFS延长一倍!, beContent=null, objectType=article, channel=null, level=null, likeNumber=207, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11164, encryptionId=82ba111646a, topicName=Lynparza), TopicDto(id=92203, encryptionId=aeef922031b, topicName=贝伐单抗), TopicDto(id=36865, encryptionId=08f236865a8, topicName=卵巢癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Nov 09 15:01:36 CST 2020, time=2020-11-09, status=1, ipAttribution=)]
    2020-11-09 Psycho.Dr Du

    卵巢癌是女性肿瘤死亡之首,目前预后仍不佳。希望能有更多早筛、早治的方法!#卵巢癌#

    0

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    2020-11-09 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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    2020-11-09 Sarah2020cpp

    不错的学习资料

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1852534, encodeId=2e6f185253413, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Tue Jan 12 00:52:15 CST 2021, time=2021-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339363, encodeId=9ab11339363d3, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Wed Nov 11 05:52:15 CST 2020, time=2020-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621375, encodeId=6cf616213e56c, content=<a href='/topic/show?id=49b313e56ad' target=_blank style='color:#2F92EE;'>#PARP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13756, encryptionId=49b313e56ad, topicName=PARP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd4d20248280, createdName=lishiwen, createdTime=Wed Nov 11 05:52:15 CST 2020, time=2020-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898012, encodeId=d8d889801206, content=卵巢癌是女性肿瘤死亡之首,目前预后仍不佳。希望能有更多早筛、早治的方法!<a href='/topic/show?id=08f236865a8' target=_blank style='color:#2F92EE;'>#卵巢癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=175, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36865, encryptionId=08f236865a8, topicName=卵巢癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210607/9f00a0de660e4b36b77a9a5f7620d6bf/98c22b17ddf7446fa7b9a618fabcb9f7.jpg, createdBy=a8fb2299762, createdName=Psycho.Dr Du, createdTime=Mon Nov 09 18:06:37 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040886, encodeId=390f1040886ae, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Nov 09 17:52:15 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897979, encodeId=5aee89e97924, content=不错的学习资料, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0e85433204, createdName=Sarah2020cpp, createdTime=Mon Nov 09 15:27:24 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897969, encodeId=345889e9697a, content=<a href='/topic/show?id=41f54454653' target=_blank style='color:#2F92EE;'>#奥拉帕利#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44546, encryptionId=41f54454653, topicName=奥拉帕利)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Nov 09 15:05:47 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897966, encodeId=041e89e966b1, content=<a href='/topic/show?id=82ba111646a' target=_blank style='color:#2F92EE;'>#Lynparza#</a>与<a href='/topic/show?id=aeef922031b' target=_blank style='color:#2F92EE;'>#贝伐单抗#</a>联合用于HRD阳性晚期<a href='/topic/show?id=08f236865a8' target=_blank style='color:#2F92EE;'>#卵巢癌#</a>患者的一线维持治疗,能提升3倍,很吓人!!PFS延长一倍!, beContent=null, objectType=article, channel=null, level=null, likeNumber=207, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11164, encryptionId=82ba111646a, topicName=Lynparza), TopicDto(id=92203, encryptionId=aeef922031b, topicName=贝伐单抗), TopicDto(id=36865, encryptionId=08f236865a8, topicName=卵巢癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Nov 09 15:01:36 CST 2020, time=2020-11-09, status=1, ipAttribution=)]
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    2020-11-09 lovetcm

    #Lynparza##贝伐单抗#联合用于HRD阳性晚期#卵巢癌#患者的一线维持治疗,能提升3倍,很吓人!!PFS延长一倍!

    0

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