Clincal Nutrition: 胃癌术后有营养风险的患者出院后口服营养补充剂好处多多

2021-02-23 MedSci原创 MedSci原创

胃癌是一种非常常见的消化道癌症,并且已成为全球癌症相关死亡的主要原因,严重威胁着人类的生命和健康。虽然有很多新颖的疗法,但手术仍是最主要的有效胃癌治疗方法。

      胃癌是一种非常常见的消化道癌症,并且已成为全球癌症相关死亡的主要原因,严重威胁着人类的生命和健康。虽然有很多新颖的疗法,但手术仍是最主要的有效胃癌治疗方法。但是,由于胃容量减少,术后化疗的增加和许多其他风险因素包括食物摄入减少和胃肠道症状,胃癌患者经常会出现营养不良的现象。有大量研究结果表明,在胃癌患者中,营养不良与不良结局持续相关,例如癌症相关发病率和死亡率,因此,使用适当的营养支持治疗对于改善营养状况和胃手术后有营养风险的患者的癌症预后大有裨益。本研究旨在探究与单独饮食建议相比,出院后口服营养补充剂(ONS)对胃癌术后患者营养结果的影响,包括体重指数(BMI)和骨骼肌指数(SMI),少肌症患病率,胃癌术后有营养风险的患者的化疗耐受性,90天再入院率和生活质量。

 

 

      本项研究共纳入了353例接受了胃癌手术且具有营养风险(营养风险筛查2002 [NRS 2002]得分≥3分)的患者。所有患者均被随机分配为接受ONS的饮食建议或仅饮食建议的,随访患者至出院后3个月。主要观察终点是营养状态和肌肉减少症患病率;次要观察终点包括化疗耐受性,90天再入院率和生活质量。

 

 

     共有337例患者完成了研究并纳入本项研究分析,其中ONS组为171例,对照组为166例。干预组的ONS平均日摄入量为370 mL。干预3个月后,与仅接受饮食建议的患者相比,接受ONS和饮食建议的患者的体重减轻显着减少,而BMI和SMI更高(P <0.05)。ONS组少肌症的发生率明显低于对照组(P <0.05)。两组患者接受术后化疗的人数相似,但是接受ONS和饮食建议的患者进行的化疗剂量调整明显较少。两组患者的90天再入院率无显着差异(P> 0.05)。关于生活质量,接受ONS和饮食建议的患者报告的疲劳和食欲明显低于仅接受饮食建议的患者(P <0.05),但两组在其他结局方面均无显着差异(P> 0.05) 。

 

      患有胃癌手术后有营养风险的患者在出院后口服ONS的饮食建议可改善营养状态,并维持骨骼肌质量。 这些发现有力地支持了向胃癌术后患者引入ONS的概念。

 

 

原始出处 :

Qingyang Meng. Et al. Post-discharge oral nutritional supplements with dietary advice in patients at nutritional risk after surgery for gastric cancer: A randomized clinical trial. Clinical Nutrition.2021.

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    2021-05-14 ms6000001608459305

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    2021-03-14 1474d367m60暂无昵称

    营养和运动治疗,大有前途

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    2021-03-08 黄昏晓Time

    胃癌术后常规进行口服营养补充,大有裨益!#胃癌#

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