JAHA:老年人身体活动以及久坐时间与心血管疾病生物标志物的关系

2018-08-08 xing.T MedSci原创

由此可见,老年人较长的轻度PA和中到高强度PA时间以及较短的久坐时间与更有利的心血管生物标志物谱相关。脂肪质量部分地介导了这些关联,但女性比男性更强,这解释了性别差异。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员只在评估客观测量的体力活动(PA)和久坐时间与60至64岁个体血管疾病生物标志物之间的关联。该研究包含了对性别差异的调查以及肥胖可能导致关联的程度。

该研究的参与者是来自于医学研究委员会全国健康与发展调查的60至64岁的795名男性和827名女性。参与者连续5天佩戴组合心率和运动传感器用于记录总体PA能量消耗(每天kJ/kg)和久坐不动(<1.5代谢当量)、轻度PA(1.5-3代谢当量)和中到高强度PA(>3代谢当量)的时间。研究人员采用线性回归模型将每个PA参数与从空腹IBD%E8%AF%8A%E6%B2%BB%E8%BF%87%E7%A8%8B%E4%B8%AD%E7%9A%84%E8%AF%84%E4%BC%B0-Part%202" target="_blank">血液样品中提取的炎性(C-反应蛋白、白细胞介素-6)、内皮(组织-纤溶酶原激活物、E-选择蛋白)和脂肪因子(瘦蛋白、脂联素)标记物联系起来。

较长的轻度PA和中到高强度PA时间以及较短的久坐时间与更有利的生物标志物水平相关。对于C反应蛋白、白细胞介素-6和瘦素,这些差异在女性中比男性更大。例如,久坐不动的男性和女性瘦素的%差异(95%置信区间)增加:7.9(2.7-13.0)和20.6(15.3-25.8); 轻度PA:-3.8(-8.9至12.7)和-17.7(-23.1至-12.4),中到高强度PA:-12.9(-17.9至-8.0)和-18.3(-23.4至-13.1)。脂肪量在女性中比男性更多地介导了这些关联。

由此可见,老年人较长的轻度PA和中到高强度PA时间以及较短的久坐时间与更有利的心血管生物标志物谱相关。脂肪质量部分地介导了这些关联,但女性比男性更强,这解释了性别差异。

原始出处:

Ahmed Elhakeem.et al. Physical Activity, Sedentary Time, and Cardiovascular Disease Biomarkers at Age 60 to 64 Years.JAHA.2018. https://www.ahajournals.org/doi/full/10.1161/JAHA.117.007459

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    2018-08-10 zhaohui6731
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    2018-08-08 医者仁心5538

    学习了

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