Alz Res Therapy:健康的生活方式,或可减少痴呆相关病理指标

2021-12-04 Freeman MedSci原创

健康的生活方式对认知完整的老年人中的AD病理学有有益影响。

阿尔茨海默病(AD)是痴呆症最常见的原因,它成为患者和社会的巨大负担。阿兹海默症的风险可以受到遗传和环境因素的影响。最近的分析表明,可改变的生活方式因素也可能影响AD的风险。研究发现,一些健康的生活方式因素与较低的痴呆风险有关。而且痴呆风险可以通过有利的生活方式因素的组合来降低。

2019年,世卫组织发布了一项预防认知能力下降和痴呆症的指南,其中包括戒烟干预、体育活动干预、社会活动干预和酒精使用障碍的干预。估计表明,如果在人口层面上消除目前确定的可改变的风险因素,超过三分之一的痴呆症病例是可以预防的。


脑脊液(CSF)中的β-淀粉样蛋白1-42(Aβ42)、总tau和磷酸化tau(p-tau)是AD的有效生物标志物。AD的生物标志物可能在诊断痴呆前20多年就已出现异常。在新公布的NIA-AA研究框架中,CSF Aβ42、tau和p-tau的水平已被确立为AD的核心生物标志物,以从生物学角度定义AD。

以前有一些关于几种健康生活方式因素和AD生物标志物之间的联系的研究,结果并不一致。生活方式因素是否对AD核心病理学有影响还不太清楚。

藉此, 复旦大学的俞金泰等人,探究了常见的健康生活方式,包括目前不吸烟,不喝有害饮料,没有社会隔离,以及定期的体育活动与阿尔茨海默病病理的CSF生物标志物的关联,这些都是在1108个认知完整的大样本中进行的。

他们对中国阿尔茨海默病生物标志物和生活方式研究(CABLE)中的1108名认知完整的个体进行研究,以评估AD生物标志物与健康生活方式因素的关系,包括无吸烟、无有害饮酒、无社会隔离和定期体育活动。根据生活方式因素,将参与者分为有利、中等和不利的生活方式组。还分析了整体生活方式和CSF生物标志物之间的关联。

他们发现:在认知完整的老年人中,有更多社会参与的人比那些有社会隔离的人有更低的CSF tau(p = 0.009)和p-tau(p < 0.001)。

定期的体育活动与较高的CSF Aβ42(p = 0.013)和较低的CSF tau(p = 0.036)和p-tau(p = 0.007)相关。

然而,没有发现吸烟状况或酒精摄入量与CSF生物标志物的明显关联。

当通过所有四个生活方式因素评估参与者的整体生活方式时,良好的生活方式与较低的CSF tau(p < 0.001)和p-tau(p < 0.001)水平有关。

这些发现表明,健康的生活方式对认知完整的老年人中的AD病理学有有益影响。


原文出处:
Hou XH, Xu W, Bi YL, et al. Associations of healthy lifestyles with cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact older adults: the CABLE study. _Alz Res Therapy_. 2021;13(1):81. doi:[10.1186/s13195-021-00822-7](https://doi.org/10.1186/s13195-021-00822-7)

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1739116, encodeId=ba1e1e39116b9, content=<a href='/topic/show?id=6e566913df' target=_blank style='color:#2F92EE;'>#ERA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6913, encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Thu Jun 09 07:50:13 CST 2022, time=2022-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077416, encodeId=e78310e7416bf, content=生活方式的重要性, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e831560211, createdName=ZYY7209, createdTime=Mon Dec 06 17:26:51 CST 2021, time=2021-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077126, encodeId=5bfd10e7126b9, content=认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sun Dec 05 18:21:39 CST 2021, time=2021-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246371, encodeId=d49312463e1ff, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Sat Dec 04 22:50:13 CST 2021, time=2021-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1076935, encodeId=715f10e693589, content=认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Dec 04 21:13:07 CST 2021, time=2021-12-04, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1739116, encodeId=ba1e1e39116b9, content=<a href='/topic/show?id=6e566913df' target=_blank style='color:#2F92EE;'>#ERA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6913, encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Thu Jun 09 07:50:13 CST 2022, time=2022-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077416, encodeId=e78310e7416bf, content=生活方式的重要性, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e831560211, createdName=ZYY7209, createdTime=Mon Dec 06 17:26:51 CST 2021, time=2021-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077126, encodeId=5bfd10e7126b9, content=认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sun Dec 05 18:21:39 CST 2021, time=2021-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246371, encodeId=d49312463e1ff, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Sat Dec 04 22:50:13 CST 2021, time=2021-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1076935, encodeId=715f10e693589, content=认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Dec 04 21:13:07 CST 2021, time=2021-12-04, status=1, ipAttribution=)]
    2021-12-06 ZYY7209

    生活方式的重要性

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1739116, encodeId=ba1e1e39116b9, content=<a href='/topic/show?id=6e566913df' target=_blank style='color:#2F92EE;'>#ERA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6913, encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Thu Jun 09 07:50:13 CST 2022, time=2022-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077416, encodeId=e78310e7416bf, content=生活方式的重要性, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e831560211, createdName=ZYY7209, createdTime=Mon Dec 06 17:26:51 CST 2021, time=2021-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077126, encodeId=5bfd10e7126b9, content=认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sun Dec 05 18:21:39 CST 2021, time=2021-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246371, encodeId=d49312463e1ff, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Sat Dec 04 22:50:13 CST 2021, time=2021-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1076935, encodeId=715f10e693589, content=认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Dec 04 21:13:07 CST 2021, time=2021-12-04, status=1, ipAttribution=)]
    2021-12-05 医鸣惊人

    认真学习了。

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1739116, encodeId=ba1e1e39116b9, content=<a href='/topic/show?id=6e566913df' target=_blank style='color:#2F92EE;'>#ERA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6913, encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Thu Jun 09 07:50:13 CST 2022, time=2022-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077416, encodeId=e78310e7416bf, content=生活方式的重要性, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e831560211, createdName=ZYY7209, createdTime=Mon Dec 06 17:26:51 CST 2021, time=2021-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077126, encodeId=5bfd10e7126b9, content=认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sun Dec 05 18:21:39 CST 2021, time=2021-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246371, encodeId=d49312463e1ff, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Sat Dec 04 22:50:13 CST 2021, time=2021-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1076935, encodeId=715f10e693589, content=认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Dec 04 21:13:07 CST 2021, time=2021-12-04, status=1, ipAttribution=)]
    2021-12-04 neuro.Dr

    老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1739116, encodeId=ba1e1e39116b9, content=<a href='/topic/show?id=6e566913df' target=_blank style='color:#2F92EE;'>#ERA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6913, encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Thu Jun 09 07:50:13 CST 2022, time=2022-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077416, encodeId=e78310e7416bf, content=生活方式的重要性, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e831560211, createdName=ZYY7209, createdTime=Mon Dec 06 17:26:51 CST 2021, time=2021-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077126, encodeId=5bfd10e7126b9, content=认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sun Dec 05 18:21:39 CST 2021, time=2021-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246371, encodeId=d49312463e1ff, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Sat Dec 04 22:50:13 CST 2021, time=2021-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1076935, encodeId=715f10e693589, content=认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Dec 04 21:13:07 CST 2021, time=2021-12-04, status=1, ipAttribution=)]
    2021-12-04 医鸣惊人

    认真学习了。

    0

相关资讯

Alz Res Therapy:基线认知功能,可有效预测认知减退

基线认知表现水平在预测模型中具有重要意义

Alz Res Therapy:整合多组学,揭示神经系统的通路变化

应用综合多组学方法,发现了与AD病理学相关的新的分子和路径改变。

Alz Res Therap:痴呆患者,患新冠后有何临床特点?

痴呆症患者的COVID-19与SARS-CoV-2感染的严重结果有关

Alz Res Therapy:右颞中叶糖代谢,或提示主观认知减退

RMTG的低代谢可能是SCD的一个典型特征,AD症状期患者的大规模低代谢可能从RMTG开始,从临床前阶段开始逐渐发展。

JAMA Neuro:血浆p-tau181、p-tau231浓度可有效预测路易体痴呆患者认知能力下降

路易体痴呆(DLB)是最常见的神经变性病性痴呆之一,仅次于阿尔茨海默病(AD)。

拓展阅读

IJNS:基于生命历程模型的多领域干预可降低老年人痴呆的风险

基于生命历程模型的多领域干预是可行的,有可能降低中国高危老年人患痴呆症的风险,改善他们的认知功能。

ART:视网膜血管的变化有望为观测阿尔茨海默病进程提供一个窗口

视网膜血管测量并不能代表非痴呆个体的脑血管损伤,而鼻侧象限的VD与海马萎缩相关,与淀粉样蛋白状态无关。

Neurology:利用基于弥散的神经炎症成像技术研究阿尔茨海默病的白质神经炎症

WM神经炎症在AD临床症状出现之前就已发生改变,并且与淀粉样变性相互作用。

Nature子刊:与记忆力训练相比,瑜伽对老年痴呆高危妇女的认知和免疫学影响

KY 对 SCD 有临床和生物学上的益处,将认知的变化与瑜伽的抗炎作用联系起来。

BMJ子刊:心血管风险负担、痴呆症风险和大脑结构成像标记——英国生物数据库研究

心血管风险负担与痴呆风险的正相关关系也适用于主要的痴呆亚型。心血管风险负担与全因痴呆的关系在很大程度上与心血管疾病的发病和痴呆的遗传易感性无关。

IJNS:老年痴呆症患者营养不良患病率和营养不良风险

结果表明,大约三分之一的痴呆症老年人存在营养不良,近一半的老年人有营养不良的风险。

2022 欧洲共识:MCI和轻度痴呆初级阶段的诊断和治疗

意大利阿尔兹海默病专家组 · 2022-10-09

适合痴呆症患者的急救护理:老年急救护理应用研究网络范围审查和共识会议的结果

急性期后和长期护理学会(AMDA,The Society for Post-Acute and Long-Term Care Medicine) · 2022-08-01

痴呆及阿尔茨海默病进展要点简析

四川大学华西医院 · 2022-07-26