Nat Aging:导致秃顶的基因,增加男性新冠风险和严重程度

2021-05-08 “生物世界”微信号 “生物世界”微信号

2021年5月6日,在欧洲皮肤病与性病学会(EADV)春季线上年会,Applied Biology公司的首席医学官 Andy Goren 博士介绍了他们的这项发现。他表示,在住院的男性新冠患者中,有7

空气污染,特别是细颗粒物(PM2.5)一直被认为是一个全球主要公共卫生问题。PM2.5,指环境空气中空气动力学当量直径小于等于 2.5 微米的颗粒物。它能较长时间悬浮于空气中,其在空气中含量浓度越高,就代表空气污染越严重。与较粗的大气颗粒物相比,PM2.5粒径小,面积大,活性强,易附带有毒、有害物质(例如,重金属、微生物等),且在大气中的停留时间长、输送距离远,因而对人体健康和大气环境质量的影响更大。

认知功能下降常见于老年人群,而环境因素会加速这种下降,比如暴露于空气中大小不超过2.5微米的细颗粒物(PM2.5)。尽管如此,短期空气污染暴露对老年人认知功能影响仍缺乏研究。

之前有研究表明,非甾体抗炎药(缓解疼痛和炎症的一类药物,如阿司匹林)可作为认知功能障碍和失智症的一种潜在疗法。不过,之前从未研究过非甾体抗炎药是否能作为空气污染对认知健康影响的一种干预手段。

2021年5月3日,北京大学公共卫生学院高旭团队在 Nature 子刊 Nature Aging 期刊发表了题为:Short-term air pollution, cognitive performance and nonsteroidal anti-inflammatory drug use in the Veterans Affairs Normative Aging Study 的研究论文。

该论文指出,短期暴露(最长28天)于高水平的空气污染中与年长男性的认知功能障碍有关。该研究还发现,在服用常见非甾体抗炎药的研究对象中,这种短期空气污染暴露的负面影响相对较轻。

2019年9月,高旭团队在美国呼吸与重症医学(AJRCCM)杂志发表了题为:Nonsteroidal Anti-Inflammatory Drugs Modify the Effect of Short-Term Air Pollution on Lung Function 的研究论文。

该研究首次证明了非甾体类抗炎药,特别是阿司匹林,可以减轻短期空气污染暴露对肺功能的不利影响,对空气污染对肺功能的不良影响具有预防作用。

在 Nature Aging 论文中,高旭等人研究了参与美国退伍军人标准化老龄研究(Veterans Affairs Normative Aging Study)的大波士顿地区的954位老年白人男性(平均年龄70岁)。在多次拜访中,利用总体认知功能和简易精神状态检查(MMSE)分数评测了这些人的认知表现。

随后再将这些数据与他们每次拜访当天当地空气中的PM2.5水平以及拜访前1-4周的PM2.5平均水平进行了对比。

对比发现,评测前最长28天的PM2.5水平升高与参与者总体认知功能分数下降有关,即使PM2.5的水平低于一般被认为危险(约≤10 μg/m3)的水平。他们还发现,服用非甾体抗炎药的研究对象受到短期空气污染暴露的不良影响较轻。

研究团队表示,仍需开展基于更大队列和更详细的非甾体抗炎药使用信息的跨学科研究,验证空气污染暴露与认知功能之间的这种关系,以及非甾体抗炎药对此的可能改善作用。

原始出处:

Gao, X., Coull, B., Lin, X. et al. Short-term air pollution, cognitive performance and nonsteroidal anti-inflammatory drug use in the Veterans Affairs Normative Aging Study. Nat Aging (2021). https://doi.org/10.1038/s43587-021-00060-4.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1885135, encodeId=6094188513599, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Mar 03 18:59:44 CST 2022, time=2022-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630436, encodeId=fb441630436d0, content=<a href='/topic/show?id=8d39e47594f' target=_blank style='color:#2F92EE;'>#秃顶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74759, encryptionId=8d39e47594f, topicName=秃顶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3be21505938, createdName=zhishijing, createdTime=Mon May 10 03:59:44 CST 2021, time=2021-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963783, encodeId=bad1963e835b, content=仍需开展基于更大队列和更详细的非甾体抗炎药使用信息的跨学科研究,验证空气污染暴露与认知功能之间的这种关系,以及非甾体抗炎药对此的可能改善作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Sat May 08 18:36:26 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963779, encodeId=73f7963e79b1, content=文不对题,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200803/bf55cfcb09b74a0cbf751a980fe04576/e4480eaa47ab42da91303dd1c72e723e.jpg, createdBy=89fd5188713, createdName=莉莉安 Lillian C., createdTime=Sat May 08 18:22:02 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1029454, encodeId=734b102945425, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat May 08 15:59:44 CST 2021, time=2021-05-08, status=1, ipAttribution=)]
    2022-03-03 zhaojie88
  2. [GetPortalCommentsPageByObjectIdResponse(id=1885135, encodeId=6094188513599, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Mar 03 18:59:44 CST 2022, time=2022-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630436, encodeId=fb441630436d0, content=<a href='/topic/show?id=8d39e47594f' target=_blank style='color:#2F92EE;'>#秃顶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74759, encryptionId=8d39e47594f, topicName=秃顶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3be21505938, createdName=zhishijing, createdTime=Mon May 10 03:59:44 CST 2021, time=2021-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963783, encodeId=bad1963e835b, content=仍需开展基于更大队列和更详细的非甾体抗炎药使用信息的跨学科研究,验证空气污染暴露与认知功能之间的这种关系,以及非甾体抗炎药对此的可能改善作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Sat May 08 18:36:26 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963779, encodeId=73f7963e79b1, content=文不对题,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200803/bf55cfcb09b74a0cbf751a980fe04576/e4480eaa47ab42da91303dd1c72e723e.jpg, createdBy=89fd5188713, createdName=莉莉安 Lillian C., createdTime=Sat May 08 18:22:02 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1029454, encodeId=734b102945425, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat May 08 15:59:44 CST 2021, time=2021-05-08, status=1, ipAttribution=)]
    2021-05-10 zhishijing
  3. [GetPortalCommentsPageByObjectIdResponse(id=1885135, encodeId=6094188513599, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Mar 03 18:59:44 CST 2022, time=2022-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630436, encodeId=fb441630436d0, content=<a href='/topic/show?id=8d39e47594f' target=_blank style='color:#2F92EE;'>#秃顶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74759, encryptionId=8d39e47594f, topicName=秃顶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3be21505938, createdName=zhishijing, createdTime=Mon May 10 03:59:44 CST 2021, time=2021-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963783, encodeId=bad1963e835b, content=仍需开展基于更大队列和更详细的非甾体抗炎药使用信息的跨学科研究,验证空气污染暴露与认知功能之间的这种关系,以及非甾体抗炎药对此的可能改善作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Sat May 08 18:36:26 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963779, encodeId=73f7963e79b1, content=文不对题,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200803/bf55cfcb09b74a0cbf751a980fe04576/e4480eaa47ab42da91303dd1c72e723e.jpg, createdBy=89fd5188713, createdName=莉莉安 Lillian C., createdTime=Sat May 08 18:22:02 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1029454, encodeId=734b102945425, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat May 08 15:59:44 CST 2021, time=2021-05-08, status=1, ipAttribution=)]
    2021-05-08 神盾医疗局局长Jack

    仍需开展基于更大队列和更详细的非甾体抗炎药使用信息的跨学科研究,验证空气污染暴露与认知功能之间的这种关系,以及非甾体抗炎药对此的可能改善作用

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1885135, encodeId=6094188513599, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Mar 03 18:59:44 CST 2022, time=2022-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630436, encodeId=fb441630436d0, content=<a href='/topic/show?id=8d39e47594f' target=_blank style='color:#2F92EE;'>#秃顶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74759, encryptionId=8d39e47594f, topicName=秃顶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3be21505938, createdName=zhishijing, createdTime=Mon May 10 03:59:44 CST 2021, time=2021-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963783, encodeId=bad1963e835b, content=仍需开展基于更大队列和更详细的非甾体抗炎药使用信息的跨学科研究,验证空气污染暴露与认知功能之间的这种关系,以及非甾体抗炎药对此的可能改善作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Sat May 08 18:36:26 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963779, encodeId=73f7963e79b1, content=文不对题,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200803/bf55cfcb09b74a0cbf751a980fe04576/e4480eaa47ab42da91303dd1c72e723e.jpg, createdBy=89fd5188713, createdName=莉莉安 Lillian C., createdTime=Sat May 08 18:22:02 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1029454, encodeId=734b102945425, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat May 08 15:59:44 CST 2021, time=2021-05-08, status=1, ipAttribution=)]
    2021-05-08 莉莉安 Lillian C.

    文不对题,谢谢

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1885135, encodeId=6094188513599, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Mar 03 18:59:44 CST 2022, time=2022-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630436, encodeId=fb441630436d0, content=<a href='/topic/show?id=8d39e47594f' target=_blank style='color:#2F92EE;'>#秃顶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74759, encryptionId=8d39e47594f, topicName=秃顶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3be21505938, createdName=zhishijing, createdTime=Mon May 10 03:59:44 CST 2021, time=2021-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963783, encodeId=bad1963e835b, content=仍需开展基于更大队列和更详细的非甾体抗炎药使用信息的跨学科研究,验证空气污染暴露与认知功能之间的这种关系,以及非甾体抗炎药对此的可能改善作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Sat May 08 18:36:26 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963779, encodeId=73f7963e79b1, content=文不对题,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200803/bf55cfcb09b74a0cbf751a980fe04576/e4480eaa47ab42da91303dd1c72e723e.jpg, createdBy=89fd5188713, createdName=莉莉安 Lillian C., createdTime=Sat May 08 18:22:02 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1029454, encodeId=734b102945425, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat May 08 15:59:44 CST 2021, time=2021-05-08, status=1, ipAttribution=)]
    2021-05-08 公卫新人

    新冠肺炎,疫情何时才能消失

    0

相关资讯

BMJ:严重秃顶男心脏病风险高48%

日前,一项最新研究表明,秃顶男比不秃顶的男子面临更大的心脏病风险。脱发年龄越年轻,问题越大。 研究者发现,患有严重脱发的男性比不秃顶的男性患有冠状动脉疾病的机率高三成三。但是这个发现仅适用于那些头顶上脱发的人。发际线在太阳穴附近渐渐上移的人并无风险。 研究还发现,年轻时就开始脱发的男性风险更大。他们脱发越多,患有心脏病的可能性越大。尽管何种因素引起了秃顶和心脏病之间的关联尚不明朗,但研究者们说

Nature:治疗秃顶有望!研究人员完全由多能干细胞产生的人体皮肤毛发  

在4-5个月的培育期内,研究人员观察到由分层表皮、富含脂肪的真皮层和带有皮脂腺的色素性毛囊组成的皮肤类器官的出现。

BJD:治疗秃顶新方法,向头部注射自己血液?

注射“富血小板血浆(PRP)”可有效减缓人们面部和手部衰老,一项最新测试表明,该方法也能使秃顶男性重新长出浓密头发。研究人员称,抽取秃顶男性体内血液的富血小板血浆,注射在头皮之下刺激新干细胞,从而促进头发再生,这一过程被称为“吸血鬼疗法”。来自国际毛发研究基金会、意大利布雷沙大学和以色列希伯来大学研究中心的科学家们共同完成了这项测试,测试者是45位男性脱发者,一部分人注射富血小板血浆;一部分人涂抹

Cell:拔头发治秃顶

评价:最新研究表明,以特定方式拔头发,可能是治疗男性脱发的好办法。当然这一研究来自小鼠的实验,理论上人类也应该具有类似的效应,但需要进行人体实验,不过这一研究并没有太大风险,作为人类患者或许可以亲自尝试一下。想象一下,如果是严重的完全没有头发的部位如何实施拔头发的方法会有一定难度。不过根据研究提供的信息,是拔头发导致的局部炎症反应,那么在局部进行炎症诱导就应该具有类似效应,例如用针刺的方法(比较不

盘点:秃顶率更高的专业排行Top 8 看医学排第几?

秃顶率最高的专业排行Top 8,前八名有你的专业吗?我们来看看上榜的专业都有哪些? 1、物理相关专业 一入物理深似海!物理老师已哭晕! 2、化学相关专业 化学老师怨气也很重!受了这么多年“熏陶”,不秃才怪! 3、计算机相关专业 4、医学相关专业 医学老师:学医苦、学医累,学医操心又受罪! 5、法学相关专业 6、数学相关专业

FASEB J:青光眼药物或成为秃顶患者的福音

2012年10月29日 讯 /生物谷BIOON/ --如果你秃顶了,想让自己的头发长出来,那么下面的报道对你绝对有帮助。近日,一项刊登于国际杂志FASEB Journal上的研究报告指出,一种FDA批准的青光眼药物比马前列素,可以促使人们头发再生长,而且该药物已经在增长个体眼睫毛上进行了商业的应用,研究者表示,实际上这种药物还可以促使个体的头发再生。 研究者Valerie Randall表示,我