Science子刊:孕妈妈注意了,妊娠期运动可减少子代肥胖!

2020-04-21 王昭月 生物探索

目前,全球的肥胖率不断上升,普遍认为这是由于缺乏运动和摄入过多热量所致。而最近的一项研究发现了又一个新的解释,即缺乏妊娠锻炼。华盛顿州立大学动物科学的研究团队指出,妊娠期运动可促进发育中的胎儿产生棕色

目前,全球的肥胖率不断上升,普遍认为这是由于缺乏运动和摄入过多热量所致。而最近的一项研究发现了又一个新的解释,即缺乏妊娠锻炼。华盛顿州立大学动物科学的研究团队指出,妊娠期运动可促进发育中的胎儿产生棕色脂肪组织(brown adipose tissue , BAT),促进其体温生成和代谢健康。该结果发表在知名期刊《Science Advances》上。

研究者将健康的怀孕小鼠分为久坐或锻炼两种。然后,给他们的后代提供高能量/高热量的饮食。通过测定并比较妊娠期运动与久坐的精瘦小鼠以及她们后代的不同指标,如肩胛间棕色脂肪iBAT(interscapular BAT, iBAT)相对质量、腹股沟白色脂肪(inguinal WAT, ingWAT)相对质量以及血糖含量、糖耐量等。


孕期运动干预可明显诱导断奶时仔鼠iBAT和ingWAT表达热原标记物


结果发现,孕期运动不仅提高了母亲的iBAT活性,利于体重控制,同时还降低怀孕小鼠的循环血糖水平和胰岛素耐受性,表明对妊娠期糖尿病的预防作用。另一方面,断奶后仔鼠不同性别间差异的检测结果显示,与久坐组相比,运动组雌雄仔鼠的iBAT均增加,且雌鼠的ingWAT也相对减少。此外,棕色脂肪细胞标记物Ucp1, Ppargc1a和Prdm16的mRNA表达也有所增加,这表明妊娠期运动可促进胎儿和断奶后代小鼠的棕色和米色脂肪生成。

研究者还发现孕期运动还能刺激母亲和胎儿产生一种运动激素—apelin,它可以刺激棕色脂肪的发育,促进后代的代谢健康和体温生成。给久坐组的怀孕小鼠注射apelin,其作用与运动对后代产生的一样有益,这进一步表明当下妇女在怀孕期间久坐不动的生活方式可能是现代社会肥胖流行的原因之一。

孕期运动通可促进棕色脂肪形成并预防子代小鼠代谢功能障碍
来源于: 华盛顿州立大学 / Jun Seok Son

资深作者Min Du说,以前的研究表明,超重妇女在怀孕期间的运动可防止后代出现代谢障碍和肥胖,本研究表明这些益处也可能延伸到健康和身材匀称的女性后代身上。同时指出, apelinegic系统可能是开发预防肥胖的药物靶点。

原始出处:
Jun Seok Son1, et al. Maternal exercise via exerkine apelin enhances brown adipogenesis and prevents metabolic dysfunction in offspring mice. Science. 17 Apr 2020

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    2020-10-12 lg.zhao
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    2020-11-08 楚钟
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    2020-04-23 jichang

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