Clin cancer res:抗肿瘤坏死因子受体抗体MK-4166治疗晚期实体肿瘤的首次临床试验结果

2021-01-01 MedSci原创 MedSci原创

靶向细胞毒性T淋巴细胞抗原4(CTLA-4)或程序性死亡受体1/程序性死亡配体1的免疫检查点抑制剂(ICI)改善了多种癌症患者的预后,但仍有很大一部分患者对ICI治疗无反应。

靶向细胞毒性T淋巴细胞抗原4(CTLA-4)或程序性死亡受体1/程序性死亡配体1的免疫检查点抑制剂(ICI)改善了多种癌症患者的预后,但仍有很大一部分患者对ICI治疗无反应。

在这项首次在人类中开展的1期试验(NCT02132754)中,研究人员探讨了靶向GITR的人源化IgG1激动剂单克隆抗体MK-4166联合或不联合派姆单抗在晚期实体瘤中的应用。

该研究分为两个队列,剂量/证明队列或扩展队列;剂量递增队列招募转移性实体瘤患者,仅予以MK-4166(0.0015-900mg)或联合派姆单抗(200mg);扩展队列招募晚期黑色素瘤患者。主要目的是明确MK-4166的最大耐受剂量,评估其安全性和耐受性。探索终点包括客观缓解率(ORR)和T细胞T细胞炎症基因表达谱(GEP)分析。

共招募了113位患者(单药治疗48例,联合治疗65例;扩展队列20例)。46位患者(40.7%)出现≥3级不良事件,其中9例(8.0%)与治疗有关。没有观察到与治疗相关的死亡。单药组中有一例剂量限制性毒性事件(膀胱穿孔)被认为与研究药物有关。

A: MK-4166的血清浓度变化;B:GITR的生物利用度变化

没有达到最大耐受量。MK-4166的药效学显示,随着剂量的增加,GITR在循环T细胞上的利用度降低。

A:扩展队列患者的肿瘤大小变化;B:ICI初治患者的反应及持续时间

在剂量递增队列(n=45)中,联合治疗组有一会患者获得客观缓解(ORR 2.2%)。在扩展队列中,13位ICI初治的黑色素瘤患者中有8位获得缓解(ORR 62%;95% CI 32%~86%;5例完全缓解和3例部分缓解)。7位经ICI预处理的患者均无应答。无论GEP状态如何,ICI初治患者均有较高的应答率。

综上所述,晚期实体瘤患者,单用MK-4166(900mg)或联合派姆单抗治疗的耐受性均在可接受范围内。从联合治疗中获益的主要是ICI初治的黑色素瘤患者。

原始出处:

Papadopoulos Kyriakos P,Autio Karen A,Golan Talia et al. Phase I Study of MK-4166, an Anti-Human Glucocorticoid-Induced Tumor Necrosis Factor Receptor Antibody, Alone or With Pembrolizumab in Advanced Solid Tumors.[J] .Clin Cancer Res, 2020, undefined: undefined.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (8)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1754581, encodeId=0fb51e54581ab, content=<a href='/topic/show?id=627a5982254' target=_blank style='color:#2F92EE;'>#晚期实体肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59822, encryptionId=627a5982254, topicName=晚期实体肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=333936755048, createdName=30397616, createdTime=Fri Jun 11 20:02:26 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362998, encodeId=75ef13629989a, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379172, encodeId=18b813e917259, content=<a href='/topic/show?id=49ed460213b' target=_blank style='color:#2F92EE;'>#实体肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46021, encryptionId=49ed460213b, topicName=实体肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c77441, createdName=weiz, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485494, encodeId=5d34148549417, content=<a href='/topic/show?id=3879828e19d' target=_blank style='color:#2F92EE;'>#肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82871, encryptionId=3879828e19d, topicName=肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43077999209, createdName=ms7524819409032184, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559819, encodeId=caa8155981939, content=<a href='/topic/show?id=61785564089' target=_blank style='color:#2F92EE;'>#抗肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55640, encryptionId=61785564089, topicName=抗肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e7415021136, createdName=zblhy, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565828, encodeId=94471565828a4, content=<a href='/topic/show?id=61785564089' target=_blank style='color:#2F92EE;'>#抗肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55640, encryptionId=61785564089, topicName=抗肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e7415021136, createdName=zblhy, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912937, encodeId=21df91293e5a, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Fri Jan 01 20:10:20 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912930, encodeId=378d91293056, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Jan 01 19:08:41 CST 2021, time=2021-01-01, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1754581, encodeId=0fb51e54581ab, content=<a href='/topic/show?id=627a5982254' target=_blank style='color:#2F92EE;'>#晚期实体肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59822, encryptionId=627a5982254, topicName=晚期实体肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=333936755048, createdName=30397616, createdTime=Fri Jun 11 20:02:26 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362998, encodeId=75ef13629989a, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379172, encodeId=18b813e917259, content=<a href='/topic/show?id=49ed460213b' target=_blank style='color:#2F92EE;'>#实体肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46021, encryptionId=49ed460213b, topicName=实体肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c77441, createdName=weiz, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485494, encodeId=5d34148549417, content=<a href='/topic/show?id=3879828e19d' target=_blank style='color:#2F92EE;'>#肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82871, encryptionId=3879828e19d, topicName=肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43077999209, createdName=ms7524819409032184, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559819, encodeId=caa8155981939, content=<a href='/topic/show?id=61785564089' target=_blank style='color:#2F92EE;'>#抗肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55640, encryptionId=61785564089, topicName=抗肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e7415021136, createdName=zblhy, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565828, encodeId=94471565828a4, content=<a href='/topic/show?id=61785564089' target=_blank style='color:#2F92EE;'>#抗肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55640, encryptionId=61785564089, topicName=抗肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e7415021136, createdName=zblhy, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912937, encodeId=21df91293e5a, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Fri Jan 01 20:10:20 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912930, encodeId=378d91293056, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Jan 01 19:08:41 CST 2021, time=2021-01-01, status=1, ipAttribution=)]
    2021-01-03 millore
  3. [GetPortalCommentsPageByObjectIdResponse(id=1754581, encodeId=0fb51e54581ab, content=<a href='/topic/show?id=627a5982254' target=_blank style='color:#2F92EE;'>#晚期实体肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59822, encryptionId=627a5982254, topicName=晚期实体肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=333936755048, createdName=30397616, createdTime=Fri Jun 11 20:02:26 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362998, encodeId=75ef13629989a, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379172, encodeId=18b813e917259, content=<a href='/topic/show?id=49ed460213b' target=_blank style='color:#2F92EE;'>#实体肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46021, encryptionId=49ed460213b, topicName=实体肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c77441, createdName=weiz, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485494, encodeId=5d34148549417, content=<a href='/topic/show?id=3879828e19d' target=_blank style='color:#2F92EE;'>#肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82871, encryptionId=3879828e19d, topicName=肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43077999209, createdName=ms7524819409032184, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559819, encodeId=caa8155981939, content=<a href='/topic/show?id=61785564089' target=_blank style='color:#2F92EE;'>#抗肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55640, encryptionId=61785564089, topicName=抗肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e7415021136, createdName=zblhy, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565828, encodeId=94471565828a4, content=<a href='/topic/show?id=61785564089' target=_blank style='color:#2F92EE;'>#抗肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55640, encryptionId=61785564089, topicName=抗肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e7415021136, createdName=zblhy, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912937, encodeId=21df91293e5a, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Fri Jan 01 20:10:20 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912930, encodeId=378d91293056, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Jan 01 19:08:41 CST 2021, time=2021-01-01, status=1, ipAttribution=)]
    2021-01-03 weiz
  4. [GetPortalCommentsPageByObjectIdResponse(id=1754581, encodeId=0fb51e54581ab, content=<a href='/topic/show?id=627a5982254' target=_blank style='color:#2F92EE;'>#晚期实体肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59822, encryptionId=627a5982254, topicName=晚期实体肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=333936755048, createdName=30397616, createdTime=Fri Jun 11 20:02:26 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362998, encodeId=75ef13629989a, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379172, encodeId=18b813e917259, content=<a href='/topic/show?id=49ed460213b' target=_blank style='color:#2F92EE;'>#实体肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46021, encryptionId=49ed460213b, topicName=实体肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c77441, createdName=weiz, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485494, encodeId=5d34148549417, content=<a href='/topic/show?id=3879828e19d' target=_blank style='color:#2F92EE;'>#肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82871, encryptionId=3879828e19d, topicName=肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43077999209, createdName=ms7524819409032184, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559819, encodeId=caa8155981939, content=<a href='/topic/show?id=61785564089' target=_blank style='color:#2F92EE;'>#抗肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55640, encryptionId=61785564089, topicName=抗肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e7415021136, createdName=zblhy, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565828, encodeId=94471565828a4, content=<a href='/topic/show?id=61785564089' target=_blank style='color:#2F92EE;'>#抗肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55640, encryptionId=61785564089, topicName=抗肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e7415021136, createdName=zblhy, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912937, encodeId=21df91293e5a, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Fri Jan 01 20:10:20 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912930, encodeId=378d91293056, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Jan 01 19:08:41 CST 2021, time=2021-01-01, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1754581, encodeId=0fb51e54581ab, content=<a href='/topic/show?id=627a5982254' target=_blank style='color:#2F92EE;'>#晚期实体肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59822, encryptionId=627a5982254, topicName=晚期实体肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=333936755048, createdName=30397616, createdTime=Fri Jun 11 20:02:26 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362998, encodeId=75ef13629989a, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379172, encodeId=18b813e917259, content=<a href='/topic/show?id=49ed460213b' target=_blank style='color:#2F92EE;'>#实体肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46021, encryptionId=49ed460213b, topicName=实体肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c77441, createdName=weiz, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485494, encodeId=5d34148549417, content=<a href='/topic/show?id=3879828e19d' target=_blank style='color:#2F92EE;'>#肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82871, encryptionId=3879828e19d, topicName=肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43077999209, createdName=ms7524819409032184, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559819, encodeId=caa8155981939, content=<a href='/topic/show?id=61785564089' target=_blank style='color:#2F92EE;'>#抗肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55640, encryptionId=61785564089, topicName=抗肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e7415021136, createdName=zblhy, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565828, encodeId=94471565828a4, content=<a href='/topic/show?id=61785564089' target=_blank style='color:#2F92EE;'>#抗肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55640, encryptionId=61785564089, topicName=抗肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e7415021136, createdName=zblhy, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912937, encodeId=21df91293e5a, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Fri Jan 01 20:10:20 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912930, encodeId=378d91293056, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Jan 01 19:08:41 CST 2021, time=2021-01-01, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1754581, encodeId=0fb51e54581ab, content=<a href='/topic/show?id=627a5982254' target=_blank style='color:#2F92EE;'>#晚期实体肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59822, encryptionId=627a5982254, topicName=晚期实体肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=333936755048, createdName=30397616, createdTime=Fri Jun 11 20:02:26 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362998, encodeId=75ef13629989a, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379172, encodeId=18b813e917259, content=<a href='/topic/show?id=49ed460213b' target=_blank style='color:#2F92EE;'>#实体肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46021, encryptionId=49ed460213b, topicName=实体肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c77441, createdName=weiz, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485494, encodeId=5d34148549417, content=<a href='/topic/show?id=3879828e19d' target=_blank style='color:#2F92EE;'>#肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82871, encryptionId=3879828e19d, topicName=肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43077999209, createdName=ms7524819409032184, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559819, encodeId=caa8155981939, content=<a href='/topic/show?id=61785564089' target=_blank style='color:#2F92EE;'>#抗肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55640, encryptionId=61785564089, topicName=抗肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e7415021136, createdName=zblhy, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565828, encodeId=94471565828a4, content=<a href='/topic/show?id=61785564089' target=_blank style='color:#2F92EE;'>#抗肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55640, encryptionId=61785564089, topicName=抗肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e7415021136, createdName=zblhy, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912937, encodeId=21df91293e5a, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Fri Jan 01 20:10:20 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912930, encodeId=378d91293056, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Jan 01 19:08:41 CST 2021, time=2021-01-01, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1754581, encodeId=0fb51e54581ab, content=<a href='/topic/show?id=627a5982254' target=_blank style='color:#2F92EE;'>#晚期实体肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59822, encryptionId=627a5982254, topicName=晚期实体肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=333936755048, createdName=30397616, createdTime=Fri Jun 11 20:02:26 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362998, encodeId=75ef13629989a, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379172, encodeId=18b813e917259, content=<a href='/topic/show?id=49ed460213b' target=_blank style='color:#2F92EE;'>#实体肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46021, encryptionId=49ed460213b, topicName=实体肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c77441, createdName=weiz, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485494, encodeId=5d34148549417, content=<a href='/topic/show?id=3879828e19d' target=_blank style='color:#2F92EE;'>#肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82871, encryptionId=3879828e19d, topicName=肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43077999209, createdName=ms7524819409032184, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559819, encodeId=caa8155981939, content=<a href='/topic/show?id=61785564089' target=_blank style='color:#2F92EE;'>#抗肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55640, encryptionId=61785564089, topicName=抗肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e7415021136, createdName=zblhy, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565828, encodeId=94471565828a4, content=<a href='/topic/show?id=61785564089' target=_blank style='color:#2F92EE;'>#抗肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55640, encryptionId=61785564089, topicName=抗肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e7415021136, createdName=zblhy, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912937, encodeId=21df91293e5a, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Fri Jan 01 20:10:20 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912930, encodeId=378d91293056, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Jan 01 19:08:41 CST 2021, time=2021-01-01, status=1, ipAttribution=)]
    2021-01-01 wxl882001

    了解

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1754581, encodeId=0fb51e54581ab, content=<a href='/topic/show?id=627a5982254' target=_blank style='color:#2F92EE;'>#晚期实体肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59822, encryptionId=627a5982254, topicName=晚期实体肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=333936755048, createdName=30397616, createdTime=Fri Jun 11 20:02:26 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362998, encodeId=75ef13629989a, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379172, encodeId=18b813e917259, content=<a href='/topic/show?id=49ed460213b' target=_blank style='color:#2F92EE;'>#实体肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46021, encryptionId=49ed460213b, topicName=实体肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c77441, createdName=weiz, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485494, encodeId=5d34148549417, content=<a href='/topic/show?id=3879828e19d' target=_blank style='color:#2F92EE;'>#肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82871, encryptionId=3879828e19d, topicName=肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43077999209, createdName=ms7524819409032184, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559819, encodeId=caa8155981939, content=<a href='/topic/show?id=61785564089' target=_blank style='color:#2F92EE;'>#抗肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55640, encryptionId=61785564089, topicName=抗肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e7415021136, createdName=zblhy, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565828, encodeId=94471565828a4, content=<a href='/topic/show?id=61785564089' target=_blank style='color:#2F92EE;'>#抗肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55640, encryptionId=61785564089, topicName=抗肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e7415021136, createdName=zblhy, createdTime=Sun Jan 03 07:02:26 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912937, encodeId=21df91293e5a, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Fri Jan 01 20:10:20 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912930, encodeId=378d91293056, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Jan 01 19:08:41 CST 2021, time=2021-01-01, status=1, ipAttribution=)]
    2021-01-01 jyzxjiangqin

    好文章!

    0

相关资讯

TC-210治疗难治性间皮素阳性实体瘤:I/II期临床试验取得积极结果

间皮素(MSLN)是多种肿瘤表面特异性表达的受体蛋白,特别是在以胰腺癌(80%~85%)为首的多种实体肿瘤中高表达,而在正常组织中间皮素的表达仅局限于胸膜、心包膜和腹膜中。

Nat Med :免疫疗法新突破!人体实验数据揭示CAR-NKT疗法治疗实体瘤的潜力

免疫疗法是当下肿瘤治疗领域最具前景的发展方向之一,其中,CAR-T疗法更是百花丛中一枝独秀。然而,尽管该疗法在血液肿瘤治疗中表现出惊人疗效,在实体瘤治疗中却频频受挫。

MSI-H/dMMR晚期实体瘤:各家PD-1/PD-L1表现如何?

2020年11月16日,先声药业宣布,与康宁杰瑞生物制药、思路迪医药达成战略合作的重组人源化PD-L1单域抗体恩沃利单抗注射液(KN035)的新药上市申请(NDA)已正式提交给国家药品监督管理局(NM

巨噬细胞疗法,向着实体瘤出发

近几年来,基因修饰的T细胞在用于治疗血液恶性肿瘤上获得了许多可喜的结果,但在实体瘤中却疗效不佳,仍然面临着很多挑战,这促使着研究学者们将目光转移到其它免疫细胞上,希望从中开发出新的替代疗法

Clin Cancer Res:免疫检查点靶向药MEDI0562治疗晚期实体瘤

免疫检查点阻断已被证明对多种实体肿瘤有临床益处;但耐药性和复发经常发生,限制了免疫检查点抑制剂的临床应用。现下,我们需要开发在激活的免疫细胞中高表达的新型免疫调节靶点。MEDI0562是一种人源化的激

STM:提高实体瘤治疗效果,中国药科大学张灿团队开发出T细胞表面锚定技术

过继性T细胞疗法虽然在血液瘤治疗中已取得优异的治疗效果,但治疗实体瘤仍面临巨大挑战。虽然目前已有将过继T细胞与细胞因子或免疫检查点抑制剂联用以改善实体瘤的治疗,但仍面临严重不良反应及系统性毒性等局限。