Cell Metabolism:中药成分可促进脂肪产热,或可用于治疗肥胖

2021-03-16 39健康网 39健康网

传统中药贯叶连翘的提取物贯叶金丝桃素能够促进脂肪组织产热。

身体质量指数(BMI)达到30以上的人群可被称为肥胖。肥胖不仅不符合当下审美,更会危害健康。因此对其进行有效的治疗不但是人们对于美的需要,也是公共卫生事业的当务之急。已有研究指出,提高脂肪组织产热有利于治疗肥胖。

近日,国际学术期刊《细胞-代谢》在线发表了上海市第六人民医院糖尿病研究所刘军力课题组题为“The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity”的研究。该研究发现,传统中药贯叶连翘的提取物贯叶金丝桃素能够促进脂肪组织产热。

研究人员希望开发出一种直接靶向模拟出脂肪细胞生理产热的药物,而CMAP基因组系统关联技术(CMap)使这一药物的筛选成为可能。他们使用CMap技术筛选得到了天然小分子化合物贯叶金丝桃素(HPF),并进一步通过实验发现HPF无细胞毒性,并具有增加脂肪细胞线粒体数量、促进产热、减小细胞体积的作用。动物实验结果显示,HPF可调节脂肪组织中的产热基因,防止肥胖。

HPF处理使小鼠体重减轻

研究人员进一步利用有限水解酶质谱法(LiP-SMap)筛选得到了HPF的直接作用靶蛋白——二氢脂酰胺S-乙酰基转移酶(dihydrolipoamide S-acetyltransferase, Dlat)。

根据包含697734名欧洲人的GWAS数据库分析,Dlat是一种与肥胖易感性有关的基因。为验证此结果,研究人员采集了健康及肥胖受试者的脂肪组织,验证了Dlat mRNA丰度与BMI具有关联。此外,敲低小鼠Dlat降低了HPF诱导对脂肪细胞的作用,这一结果共同证实HPF通过DLAT介导脂肪组织产热。

HPF通过DLAT发挥作用

贯叶金丝桃是一种传统的中药材,又名贯叶连翘。此研究揭示了其提取物HPF对脂肪产热的积极作用,并证实了HPF在肥胖症治疗中的潜力和中药材在现代药理学中的价值。今后,靶向脂肪细胞产热代谢的药物,尤其是中药材提取物或可成为肥胖治疗的新途径,且有望开发出更加安全有效的减肥药物。

原始出处:

Suzhen Chen, et al. The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity. Cell Metabolosm, 2021. DOI:https://doi.org/10.1016/j.cmet.2021.02.007.

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    2021-06-27 一闲
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    2021-05-25 guojianrong
  4. [GetPortalCommentsPageByObjectIdResponse(id=1896819, encodeId=ca5918968194b, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun Jun 27 02:07:39 CST 2021, time=2021-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1797116, encodeId=2a271e97116ff, content=<a href='/topic/show?id=3dc7224649a' target=_blank style='color:#2F92EE;'>#中药成分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22464, encryptionId=3dc7224649a, topicName=中药成分)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Fri Apr 16 09:07:39 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888276, encodeId=8d0318882e6d8, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Tue May 25 23:07:39 CST 2021, time=2021-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962478, encodeId=2e3419624e8c8, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sun Oct 24 01:07:39 CST 2021, time=2021-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872169, encodeId=94e418e21690e, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Wed Sep 22 01:07:39 CST 2021, time=2021-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950564, encodeId=6f409505643f, content=贯叶金丝桃又名贯叶连翘、圣约翰草。圣约翰草,细胞色素P450酶的诱导剂,如雷贯耳啊!不知道金丝桃素是否也是P450酶的诱导剂?, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=46905128057, createdName=zy&kt, createdTime=Tue Mar 23 23:46:13 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577259, encodeId=d93a15e725981, content=<a href='/topic/show?id=d86d1159e36' target=_blank style='color:#2F92EE;'>#Metabolism#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11597, encryptionId=d86d1159e36, topicName=Metabolism)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a6516392333, createdName=1249859em43(暂无昵称), createdTime=Thu Mar 18 11:07:39 CST 2021, time=2021-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598109, encodeId=b1481598109df, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Thu Mar 18 11:07:39 CST 2021, time=2021-03-18, status=1, ipAttribution=)]
    2021-10-24 维他命
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    2021-03-23 zy&kt

    贯叶金丝桃又名贯叶连翘、圣约翰草。圣约翰草,细胞色素P450酶的诱导剂,如雷贯耳啊!不知道金丝桃素是否也是P450酶的诱导剂?

    0

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    2021-03-18 闆锋旦

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