Scient Rep:“根除”艾滋病毒的新方法

2017-10-03 佚名 medicalxpress

近年来,艾滋病的治疗方法与日俱进,但是谈到根治始终有一段很远的距离。日前,日本熊本大学的研究人员开发了一种新的化合物,是破坏艾滋病病毒的关键。化合物引入感染细胞时,从而围在宿主细胞周围的病毒释放,然后通过细胞凋亡的过程,细胞自然死亡。这种疗法是可以使艾滋病在不久的将来的完全恢复的希望。

近年来,艾滋病的治疗方法与日俱进,但是谈到根治始终有一段很远的距离。日前,日本熊本大学的研究人员开发了一种新的化合物,是破坏艾滋病病毒的关键。化合物引入感染细胞时,从而围在宿主细胞周围的病毒释放,然后通过细胞凋亡的过程,细胞自然死亡。这种疗法是可以使艾滋病在不久的将来的完全恢复的希望。

多种药物治疗能抑制体内艾滋病毒增殖,然而,这些方法不能删除潜伏的艾滋病病毒以及它们的栖息地,而且,一旦药物停止,病毒载量将再次增加,因此,找到艾滋病毒的栖息地是目前艾滋病研究的最高目标。

“踢和杀”的方法是几年前开发的可以剔除储层细胞的战略,这种技术使用的药物目标是储层细胞,激活病毒然后让免疫系统发现这些细胞,并使用激活病毒作为地标。虽然这种方法还处于临床测试阶段,但是仍存在一些问题,因为激活成功之后,并不能关闭病毒。

熊本大学的研究人员开发出一种新方法,他们称之为“锁定和细胞凋亡法”。首先,他们合成复合L-HIPPO强烈结合HIV蛋白Pr55Gag,抑制病毒出芽。当L-HIPPO加入病毒,被感染细胞通过一个称为α-CDE载体,细胞和细胞内的病毒就会通过自然凋亡而死亡。

研究人员表示,这种锁定新方法一定会在不久的将来完全根除艾滋病,还世界一片健康的天空。

原始出处:

Hiroshi Tateishi, Kazuaki Monde, Kensaku Anraku, et.al. A clue to unprecedented strategy to HIV eradication:"Lock-in and apoptosis". Scientific Reports

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    2018-07-31 风铃830
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    2017-10-05 jichang
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    2017-10-04 1861ff86b0m

    快点吧

    0

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    2017-10-03 Y—xianghai

    学习了新知识

    0

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