JAHA:早期预测卒中相关并发症的血液生物标志物组合

2021-02-27 MedSci原创 MedSci原创

血液生物标志物可用于ADHF和RTI的早期预测。未来的研究应该集中于评估这些组合在既往卒中并伴有呼吸系统症状患者中的有用性。

急性失代偿性心力衰竭(ADHF)和呼吸道感染(RTIs)是既往有卒中患者住院期间容易发生的威胁生命的并发症。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在评估血液生物标志物组能否在入院后早期预测这些并发症。

该研究前瞻性地招募了389名发生缺血性卒中的患者。研究人员回顾性地分析了受试者住院期间的卒中后并发症。研究人员在受试者卒中发作后6小时内抽取血样,并通过免疫测定法分析14种生物标志物,并使用对数转换和Z评分对生物标志物值进行标准化。研究人员使用PanelomiX算法选择具有最高精度的生物标志物组合来预测ADHF和RTI,并使用临床变量和生物标志物组构建Logistic回归模型进行分析。与单一临床模型相比,研究人员通过受试者操作特征曲线评估了组合的附加预测值,并通过3次重复的10倍交叉验证进行了内部验证。

该研究分别有19例(2%)和86例(9.1%)受试者发生ADHF和RTI。研究人员开发了三种生物标志物作为预测指标:对于ADHF为血管粘附蛋白-1>5.67、NT-proBNP(B型利钠肽前体N-末端)>4.98和d-二聚体>5.38(敏感性为89.5%;特异性为71.7% );对于RTI为白介素-6>3.97、von Willebrand因子>3.67、d-二聚体>4.58(敏感性为82.6%;特异性为59.8%)。两个组合经临床混杂因素调整后均可独立预测卒中并发症(ADHF:比值比[OR,95%CI]为10.1 [3–52.2];RTI:OR为3.73 [1.95-7.14])。在两种情况下,将组合添加到临床预测指标可显著改善受试者工作特征曲线曲线下面积。

由此可见,血液生物标志物可用于ADHF和RTI的早期预测。未来的研究应该集中于评估这些组合在既往卒中并伴有呼吸系统症状患者中的有用性

原始出处:

Júlia Faura.et al.Blood Biomarker Panels for the Early Prediction of Stroke‐Associated Complications.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/10.1161/JAHA.120.018946

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    2021-10-07 丁鹏鹏
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    2021-03-01 zhaohui6731
  5. [GetPortalCommentsPageByObjectIdResponse(id=1841647, encodeId=5963184164e41, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Tue Aug 03 16:43:38 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1758311, encodeId=68181e5831163, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Thu Oct 07 14:43:38 CST 2021, time=2021-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800328, encodeId=eed1180032854, content=<a href='/topic/show?id=dc8be25311a' target=_blank style='color:#2F92EE;'>#相关并发症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72531, encryptionId=dc8be25311a, topicName=相关并发症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce5632, createdName=jianjun66, createdTime=Fri Apr 23 15:43:38 CST 2021, time=2021-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268439, encodeId=320f1268439e4, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Mon Mar 01 02:43:38 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561010, encodeId=6d871561010bb, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Mon Mar 01 02:43:38 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567019, encodeId=a681156e019d7, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Mon Mar 01 02:43:38 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026776, encodeId=08de1026e7618, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Feb 27 14:43:38 CST 2021, time=2021-02-27, status=1, ipAttribution=)]
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1841647, encodeId=5963184164e41, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Tue Aug 03 16:43:38 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1758311, encodeId=68181e5831163, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Thu Oct 07 14:43:38 CST 2021, time=2021-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800328, encodeId=eed1180032854, content=<a href='/topic/show?id=dc8be25311a' target=_blank style='color:#2F92EE;'>#相关并发症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72531, encryptionId=dc8be25311a, topicName=相关并发症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce5632, createdName=jianjun66, createdTime=Fri Apr 23 15:43:38 CST 2021, time=2021-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268439, encodeId=320f1268439e4, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Mon Mar 01 02:43:38 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561010, encodeId=6d871561010bb, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Mon Mar 01 02:43:38 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567019, encodeId=a681156e019d7, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Mon Mar 01 02:43:38 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026776, encodeId=08de1026e7618, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Feb 27 14:43:38 CST 2021, time=2021-02-27, status=1, ipAttribution=)]
    2021-02-27 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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