Biomater Sci:3D打印胶原蛋白/硫酸肝素支架促进犬脑外伤后的神经网络重建和运动功能恢复

2021-08-02 MedSci原创 MedSci原创

组织工程被认为对创伤性脑损伤(TBI)的修复具有很大的前景,许多研究已经证明了生物材料和3D打印的功效。虽然胶原蛋白以其天然特性而闻名,但一些缺陷仍然限制了其在组织修复中的潜在应用。

组织工程被认为对创伤性脑损伤(TBI)的修复具有很大的前景,许多研究已经证明了生物材料和3D打印的功效。虽然胶原蛋白以其天然特性而闻名,但一些缺陷仍然限制了其在组织修复中的潜在应用。

在这项实验研究中,研究人员通过3D打印技术制造了一种由胶原蛋白和硫酸肝素组成的支架,它具有良好的物理特性和合适的降解率,以及令人满意的细胞相容性。植入后,运动诱发电位(MEPs)的结果显示,偏瘫肢体的潜伏期和振幅都得到了改善,并且在磁共振成像(MRI)评估下,大脑皮层和皮质脊髓束的结构完整性也得到了明显的增强。原位杂交(ISH)和免疫荧光染色的结果也显示了3D打印胶原蛋白/硫酸肝素支架对血管和神经再生的促进作用。此外,植入这种支架的个体呈现出更好的步态特征,以及更好的肌电图和肌张力

总的来说,3D打印的胶原蛋白/硫酸肝素支架在结构修复和功能改善方面都有很好的表现,可能为创伤性脑损伤的修复提供一种新的策略。

 

原始出处:

 

Jipeng Jiang, et al., 3D printing collagen/heparin sulfate scaffolds boost neural network reconstruction and motor function recovery after traumatic brain injury in canine. Biomater Sci. 2020 Nov 21;8(22):6362-6374. doi: 10.1039/d0bm01116a. 

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    2021-12-03 sunylz
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    2021-08-04 mnda
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