NEUROBIOL AGING:肥胖与脑血流减少有关

2021-05-08 K.K MedSci原创

超重或肥胖会显着减少大脑血流量,而增加体育活动可以改变大脑血流量的减少

在全球范围内,肥胖越来越普遍,临床上,约3亿人肥胖,超10亿成年人超重。肥胖或超重仍然是慢性病和残疾的主要风险因素,它们影响了人们的整体生活质量。肥胖会使一个人在四十岁以后容易出现与年龄有关的疾病,还可能使男性的预期寿命减少六年,女性的预期寿命减少七年。在爱尔兰,肥胖和超重是一个相当大的健康问题。

 

Silvin P. Knight et al. Obesity is associated with reduced cerebral blood flow – modified by physical activity,Neurobiology of Aging(2021).DOI: 10.1016/j.neurobiolaging.2021.04.008

来自爱尔兰老龄化纵向研究(TILDA)的科学家们,调查了50岁以上成年人的身体质量指数(BMI)、腰臀比和腰围、体育活动后发现:超重或肥胖会显着减少大脑血流量,而增加体育活动可以改变大脑血流量的减少。具体而言:

  • BMI、腰臀比和腰围增加与大脑供血的减少有关。
  • 腰围增加1厘米与脑血流量减少、与年龄增加1岁的情况相同。
  • 在老年人中,肥胖和大脑供血减少之间存在明显的关联。

大脑血流量减少,是血管性痴呆症的早期征兆。稳定、健康的大脑供血是至关重要的,因为它能确保大脑获得足够的氧气和营养物质。随着我们年龄的增长,大脑血流减少,它可能导致严重的健康问题,如增加痴呆症的风险,但这项研究中,在脑血流量的负面影响方面,肥胖因素比年龄因素产生的负面影响更大。然而,身体活跃有助于抵消肥胖对脑血流的负面影响,研究建议全天至少有1.5~2小时的体育活动,如快走或骑自行车,这些活动有助于维持和潜在地改善大脑血流水平。

当我们为日益增长的老龄化社会做准备时,可以利用上述证据来制定有意义的公共卫生政策,促进积极的生活习惯,以减轻肥胖危害。

 

Overweight or obesity can significantly reduce the flow of blood to the brain, and increased physical activity can change the flow of blood to the brain

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    2022-03-04 sunylz
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    2021-05-14 ms7000000598878159

    这是脑重量占体重的比例有关

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2042276, encodeId=763d20422e664, content=<a href='/topic/show?id=754b8508329' target=_blank style='color:#2F92EE;'>#脑血流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85083, encryptionId=754b8508329, topicName=脑血流)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b191324, createdName=marongnuan, createdTime=Tue Oct 12 11:12:56 CST 2021, time=2021-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1919257, encodeId=7154191925e08, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Mar 04 20:12:56 CST 2022, time=2022-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767847, encodeId=dcef1e67847fc, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Wed Nov 10 11:12:56 CST 2021, time=2021-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=965637, encodeId=ca7c96563eea, content=这是脑重量占体重的比例有关, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10735431394, createdName=ms7000000598878159, createdTime=Fri May 14 18:26:09 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=964431, encodeId=c19896443153, content=运动, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJ42hR3zb89ZzkZVKorv74I6shMF3VlGLtBZczsr6uVSjeBF7ZAU2KLicPa2NekAOGfIglm1lDVwgA/132, createdBy=01945233793, createdName=杨三, createdTime=Mon May 10 23:10:02 CST 2021, time=2021-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=964421, encodeId=b368964421b1, content=多运动, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66942067627, createdName=1881ef655dm, createdTime=Mon May 10 22:51:37 CST 2021, time=2021-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963902, encodeId=95b19639023f, content=谢谢(*°∀°)=3, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210507/d2f454213dbb4791990da24f75d0b4a2/1b93dd0ed9724ff794244a92e96dc986.jpg, createdBy=cc102562808, createdName=crazy886, createdTime=Sun May 09 09:44:25 CST 2021, time=2021-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963823, encodeId=23f6963823c9, content=肥胖对于所有疾病的发生都有消极的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ebbd5338247, createdName=dqdqdq, createdTime=Sat May 08 22:28:54 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963787, encodeId=8d71963e873d, content=所以多运动, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210508/d7c1b9030fb84f88941463bd349091dc/ca6aeda5cd894db89bdc8639028aac25.jpg, createdBy=8a925478455, createdName=ms8000001304335137, createdTime=Sat May 08 18:51:48 CST 2021, time=2021-05-08, status=1, ipAttribution=)]
    2021-05-10 杨三

    运动

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2042276, encodeId=763d20422e664, content=<a href='/topic/show?id=754b8508329' target=_blank style='color:#2F92EE;'>#脑血流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85083, encryptionId=754b8508329, topicName=脑血流)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b191324, createdName=marongnuan, createdTime=Tue Oct 12 11:12:56 CST 2021, time=2021-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1919257, encodeId=7154191925e08, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Mar 04 20:12:56 CST 2022, time=2022-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767847, encodeId=dcef1e67847fc, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Wed Nov 10 11:12:56 CST 2021, time=2021-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=965637, encodeId=ca7c96563eea, content=这是脑重量占体重的比例有关, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10735431394, createdName=ms7000000598878159, createdTime=Fri May 14 18:26:09 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=964431, encodeId=c19896443153, content=运动, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJ42hR3zb89ZzkZVKorv74I6shMF3VlGLtBZczsr6uVSjeBF7ZAU2KLicPa2NekAOGfIglm1lDVwgA/132, createdBy=01945233793, createdName=杨三, createdTime=Mon May 10 23:10:02 CST 2021, time=2021-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=964421, encodeId=b368964421b1, content=多运动, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66942067627, createdName=1881ef655dm, createdTime=Mon May 10 22:51:37 CST 2021, time=2021-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963902, encodeId=95b19639023f, content=谢谢(*°∀°)=3, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210507/d2f454213dbb4791990da24f75d0b4a2/1b93dd0ed9724ff794244a92e96dc986.jpg, createdBy=cc102562808, createdName=crazy886, createdTime=Sun May 09 09:44:25 CST 2021, time=2021-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963823, encodeId=23f6963823c9, content=肥胖对于所有疾病的发生都有消极的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ebbd5338247, createdName=dqdqdq, createdTime=Sat May 08 22:28:54 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963787, encodeId=8d71963e873d, content=所以多运动, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210508/d7c1b9030fb84f88941463bd349091dc/ca6aeda5cd894db89bdc8639028aac25.jpg, createdBy=8a925478455, createdName=ms8000001304335137, createdTime=Sat May 08 18:51:48 CST 2021, time=2021-05-08, status=1, ipAttribution=)]
    2021-05-10 1881ef655dm

    多运动

    0

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    2021-05-09 crazy886

    谢谢(*°∀°)=3

    0

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    2021-05-08 dqdqdq

    肥胖对于所有疾病的发生都有消极的作用

    0

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    2021-05-08 ms8000001304335137

    所以多运动

    0

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