JAMA Oncol :咖啡又一功效!可改善结直肠癌晚期或转移性患者的生存率和恶化风险

2020-10-14 王木木 生物探索

结直肠癌(CRC)是世界第三高发恶性肿瘤,近十年来在我国的发病率逐年上升。大量的CRC患者最终会发展成转移性疾病,姑息性治疗的5年生存率仅为14%。

结直肠癌(CRC)是世界第三高发恶性肿瘤,近十年来在我国的发病率逐年上升。大量的CRC患者最终会发展成转移性疾病,姑息性治疗的5年生存率仅为14%。因此,开发改善转移性CRC患者预后的新治疗策略具有特殊而重要的临床意义。

目前大量的实验和流行病学研究发现,饮食和其他生活方式会影响CRC的发病率和死亡率。咖啡中发现的几种化合物具有抗氧化,抗炎和胰岛素敏感的作用,可能有助于抗癌。

近日,来自美国达纳-法伯癌症研究所和梅奥诊所医学院的团队对结直肠癌患者的咖啡摄入量与其生存率之间的关联进行研究,发现喝咖啡可能会降低晚期或转移性CRC疾病进展和死亡的风险,每天喝两至三杯咖啡的患者总体上寿命更长,病情恶化风险更低,每天喝四杯以上咖啡则受益更大。相关成果于2020年9月17日发表在《JAMA Oncology》上。

研究人员从癌症和白血病B组(CALGB)的3期随机临床试验研究数据中,筛选出1171例晚期或转移性CRC患者,其中86%为白人,中位年龄为59岁,男性占比59%。对参与者的日常中含咖啡因的咖啡和不含咖啡因的咖啡的消耗量,以及从食物中获取的咖啡因摄入量进行统计。同时记录了其体重指数(BMI)、药物使用情况、烟酒、体育活动等协变量信息。然后将这些数据与癌症治疗后的病程进行关联研究和分析。

不同总咖啡消耗频率患者的总生存率(OS)和无进展生存率(PFS)

在5.4年的中位随访期间,共有1092名患者(93%)出现死亡或疾病恶化。使用Cox风险回归模型分析咖啡摄入量与CRC进展和死亡间的关联,调整协变量信息后,发现摄入较多量的咖啡,可显着改善患者的总生存期(OS),其总体上寿命更长。与不喝咖啡的人相比,每天喝2到3杯咖啡的患者OS的危险比为0.82,每天至少喝4杯咖啡的患者OS的危险比则为0.64。而这一受益与摄入的咖啡中是否含咖啡因无关。

总、含咖啡因和脱咖啡因咖啡摄入量与OS和PFS的关联

除此之外,较高的总咖啡摄入量也与无进展生存期(PFS)的改善有关。与不喝咖啡的人相比,每天喝2到3杯咖啡可使患者的病情恶化风险降低18%,而每天至少喝4杯咖啡可使患者的病情恶化风险降低22%。

OS和PFS的多变量调整危险比(HRs)和95% CIs

该研究的作者Kimmie Ng表示:“这项研究支持了饮食和其他可改变因素在治疗大肠癌中的重要性。但将高摄入量的咖啡作为结直肠癌的潜在治疗方法还为时过早,我们仍需进一步的研究来确定在大肠癌患者中咖啡的摄入量与结局改善之间是否确实存在因果关系,以及咖啡中的哪些化合物才是造成这种益处的确切原因。”

原始出处:

Christopher Mackintosh, Chen Yuan, Fang-Shu Ou, et al.Association of Coffee Intake With Survival in Patients With Advanced or Metastatic Colorectal Cancer.JAMA Oncol. 2020 ;e203938. doi: 10.1001/jamaoncol.2020.3938.

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    2021-06-04 minlingfeng
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  4. [GetPortalCommentsPageByObjectIdResponse(id=1865927, encodeId=6058186592e73, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri Jun 04 17:37:02 CST 2021, time=2021-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256791, encodeId=e2171256e91b9, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Fri Oct 16 07:37:02 CST 2020, time=2020-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1386672, encodeId=333313866e22d, content=<a href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Fri Oct 16 07:37:02 CST 2020, time=2020-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453427, encodeId=fa24145342eff, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Fri Oct 16 07:37:02 CST 2020, time=2020-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=892328, encodeId=cbc5892328a8, content=喜欢喝咖啡,每天一杯。 但是咖啡也不能喝太多,要不然晚上睡不着。睡眠不足会导致很多健康问题。 所以适量就好。, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Oct 15 21:41:21 CST 2020, time=2020-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036304, encodeId=276610363046e, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Oct 14 19:37:02 CST 2020, time=2020-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038129, encodeId=3abc10381299e, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Wed Oct 14 19:37:02 CST 2020, time=2020-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=892064, encodeId=d6d089206464, content=<a href='/topic/show?id=5fae39e738a' target=_blank style='color:#2F92EE;'>#咖啡#</a>改善<a href='/topic/show?id=493ae869206' target=_blank style='color:#2F92EE;'>#结直肠癌#</a>晚期或转移性患者的生存率和恶化风险,看来大灌咖啡了??实际上并不可以的,还要看具体情况,咖啡也许有一定的好处,但是可能还与更多的因素有关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=300, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39773, encryptionId=5fae39e738a, topicName=咖啡), TopicDto(id=78692, encryptionId=493ae869206, topicName=结直肠癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed Oct 14 17:33:09 CST 2020, time=2020-10-14, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1865927, encodeId=6058186592e73, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri Jun 04 17:37:02 CST 2021, time=2021-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256791, encodeId=e2171256e91b9, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Fri Oct 16 07:37:02 CST 2020, time=2020-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1386672, encodeId=333313866e22d, content=<a href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Fri Oct 16 07:37:02 CST 2020, time=2020-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453427, encodeId=fa24145342eff, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Fri Oct 16 07:37:02 CST 2020, time=2020-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=892328, encodeId=cbc5892328a8, content=喜欢喝咖啡,每天一杯。 但是咖啡也不能喝太多,要不然晚上睡不着。睡眠不足会导致很多健康问题。 所以适量就好。, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Oct 15 21:41:21 CST 2020, time=2020-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036304, encodeId=276610363046e, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Oct 14 19:37:02 CST 2020, time=2020-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038129, encodeId=3abc10381299e, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Wed Oct 14 19:37:02 CST 2020, time=2020-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=892064, encodeId=d6d089206464, content=<a href='/topic/show?id=5fae39e738a' target=_blank style='color:#2F92EE;'>#咖啡#</a>改善<a href='/topic/show?id=493ae869206' target=_blank style='color:#2F92EE;'>#结直肠癌#</a>晚期或转移性患者的生存率和恶化风险,看来大灌咖啡了??实际上并不可以的,还要看具体情况,咖啡也许有一定的好处,但是可能还与更多的因素有关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=300, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39773, encryptionId=5fae39e738a, topicName=咖啡), TopicDto(id=78692, encryptionId=493ae869206, topicName=结直肠癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed Oct 14 17:33:09 CST 2020, time=2020-10-14, status=1, ipAttribution=)]
    2020-10-15 Jessica

    喜欢喝咖啡,每天一杯。 但是咖啡也不能喝太多,要不然晚上睡不着。睡眠不足会导致很多健康问题。 所以适量就好。

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1865927, encodeId=6058186592e73, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri Jun 04 17:37:02 CST 2021, time=2021-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256791, encodeId=e2171256e91b9, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Fri Oct 16 07:37:02 CST 2020, time=2020-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1386672, encodeId=333313866e22d, content=<a href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Fri Oct 16 07:37:02 CST 2020, time=2020-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453427, encodeId=fa24145342eff, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Fri Oct 16 07:37:02 CST 2020, time=2020-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=892328, encodeId=cbc5892328a8, content=喜欢喝咖啡,每天一杯。 但是咖啡也不能喝太多,要不然晚上睡不着。睡眠不足会导致很多健康问题。 所以适量就好。, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Oct 15 21:41:21 CST 2020, time=2020-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036304, encodeId=276610363046e, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Oct 14 19:37:02 CST 2020, time=2020-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038129, encodeId=3abc10381299e, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Wed Oct 14 19:37:02 CST 2020, time=2020-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=892064, encodeId=d6d089206464, content=<a href='/topic/show?id=5fae39e738a' target=_blank style='color:#2F92EE;'>#咖啡#</a>改善<a href='/topic/show?id=493ae869206' target=_blank style='color:#2F92EE;'>#结直肠癌#</a>晚期或转移性患者的生存率和恶化风险,看来大灌咖啡了??实际上并不可以的,还要看具体情况,咖啡也许有一定的好处,但是可能还与更多的因素有关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=300, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39773, encryptionId=5fae39e738a, topicName=咖啡), TopicDto(id=78692, encryptionId=493ae869206, topicName=结直肠癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed Oct 14 17:33:09 CST 2020, time=2020-10-14, status=1, ipAttribution=)]
    2020-10-14 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1865927, encodeId=6058186592e73, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri Jun 04 17:37:02 CST 2021, time=2021-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256791, encodeId=e2171256e91b9, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Fri Oct 16 07:37:02 CST 2020, time=2020-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1386672, encodeId=333313866e22d, content=<a href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Fri Oct 16 07:37:02 CST 2020, time=2020-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453427, encodeId=fa24145342eff, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Fri Oct 16 07:37:02 CST 2020, time=2020-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=892328, encodeId=cbc5892328a8, content=喜欢喝咖啡,每天一杯。 但是咖啡也不能喝太多,要不然晚上睡不着。睡眠不足会导致很多健康问题。 所以适量就好。, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Oct 15 21:41:21 CST 2020, time=2020-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036304, encodeId=276610363046e, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Oct 14 19:37:02 CST 2020, time=2020-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038129, encodeId=3abc10381299e, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Wed Oct 14 19:37:02 CST 2020, time=2020-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=892064, encodeId=d6d089206464, content=<a href='/topic/show?id=5fae39e738a' target=_blank style='color:#2F92EE;'>#咖啡#</a>改善<a href='/topic/show?id=493ae869206' target=_blank style='color:#2F92EE;'>#结直肠癌#</a>晚期或转移性患者的生存率和恶化风险,看来大灌咖啡了??实际上并不可以的,还要看具体情况,咖啡也许有一定的好处,但是可能还与更多的因素有关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=300, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39773, encryptionId=5fae39e738a, topicName=咖啡), TopicDto(id=78692, encryptionId=493ae869206, topicName=结直肠癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed Oct 14 17:33:09 CST 2020, time=2020-10-14, status=1, ipAttribution=)]
    2020-10-14 anti-cancer

    谢谢梅斯分享这么多精彩信息

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1865927, encodeId=6058186592e73, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri Jun 04 17:37:02 CST 2021, time=2021-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256791, encodeId=e2171256e91b9, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Fri Oct 16 07:37:02 CST 2020, time=2020-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1386672, encodeId=333313866e22d, content=<a href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Fri Oct 16 07:37:02 CST 2020, time=2020-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453427, encodeId=fa24145342eff, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Fri Oct 16 07:37:02 CST 2020, time=2020-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=892328, encodeId=cbc5892328a8, content=喜欢喝咖啡,每天一杯。 但是咖啡也不能喝太多,要不然晚上睡不着。睡眠不足会导致很多健康问题。 所以适量就好。, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Oct 15 21:41:21 CST 2020, time=2020-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036304, encodeId=276610363046e, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Oct 14 19:37:02 CST 2020, time=2020-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038129, encodeId=3abc10381299e, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Wed Oct 14 19:37:02 CST 2020, time=2020-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=892064, encodeId=d6d089206464, content=<a href='/topic/show?id=5fae39e738a' target=_blank style='color:#2F92EE;'>#咖啡#</a>改善<a href='/topic/show?id=493ae869206' target=_blank style='color:#2F92EE;'>#结直肠癌#</a>晚期或转移性患者的生存率和恶化风险,看来大灌咖啡了??实际上并不可以的,还要看具体情况,咖啡也许有一定的好处,但是可能还与更多的因素有关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=300, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39773, encryptionId=5fae39e738a, topicName=咖啡), TopicDto(id=78692, encryptionId=493ae869206, topicName=结直肠癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed Oct 14 17:33:09 CST 2020, time=2020-10-14, status=1, ipAttribution=)]
    2020-10-14 lovetcm

    #咖啡#改善#结直肠癌#晚期或转移性患者的生存率和恶化风险,看来大灌咖啡了??实际上并不可以的,还要看具体情况,咖啡也许有一定的好处,但是可能还与更多的因素有关。

    0

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