Cell子刊:颠覆常规!在世界上首次角膜存在T细胞,它们保护眼睛免受病毒感染

2022-05-31 生物谷 生物谷

人类要看东西,角膜必须保持透明,以确保视网膜能通过虹膜接收到聚焦的光线。之前没有考虑到角膜中存在T细胞,因为眼睛只产生一种受到抑制的免疫反应,以避免会阻碍我们视力的炎症。

在一项新的研究中,来自据彼得-多尔蒂感染免疫研究所、墨尔本大学和莫纳什大学的研究人员发现作为眼睛中对帮助我们看东西至关重要的透明保护外层,角膜产生了一种微妙而有限的免疫反应,以对抗感染而不损害我们的视力。相关研究结果发表在2022年5月24日的期刊上,论文标题为“Corneal tissue-resident memory T cells form a unique immune compartment at the ocular surface”。

这项新的研究表明巡视和抗击病毒感染的长寿命记忆T细胞存在于角膜中,颠覆了目前认为T细胞不存在于健康角膜中的观点,这扩大了我们对眼睛产生免疫反应应对感染的了解。

这些作者使用一种多光子显微镜,提供活的、完整的生物组织的实时图像,以便研究感染了单纯疱疹病毒(HSV)的小鼠角膜细胞。

他们的图像显示小鼠的眼睛中产生了长期存活的记忆T细胞来对抗感染。在这种病毒被消除后,这些记忆T细胞仍留在角膜上,以抵御未来出现的任何HSV再次感染。对健康人的眼睛进行的高级成像也显示了在角膜上巡逻的免疫细胞---这是第一次对人眼睛中的细胞运动进行成像。

图片来自Cell Reports, 2022, doi:10.1016/j.celrep.2022.110852。

人类要看东西,角膜必须保持透明,以确保视网膜能通过虹膜接收到聚焦的光线。之前没有考虑到角膜中存在T细胞,因为眼睛只产生一种受到抑制的免疫反应,以避免会阻碍我们视力的炎症。

论文通讯作者、彼得-多尔蒂感染与免疫研究所实验室负责人Scott Mueller教授说,这些发现对了解眼睛如何抵御危险的感染有重要意义。

Mueller教授说,“目前关于健康角膜中没有T细胞的理解需要重新考虑,因为我们的发现显示组织驻留的记忆T细胞进入角膜并长期留在那里。我们的发现将提高人们对如何保护我们的眼睛免受导致永久失明的感染(比如HSV感染)的理解。这也对理解慢性疾病,如干眼症和常见的眼部过敏,有意义,在这些疾病中,不需要的T细胞也可能导致疾病。”

参考资料:

Joon Keit Loi et al. Corneal tissue-resident memory T cells form a unique immune compartment at the ocular surface. Cell Reports, 2022, doi:10.1016/j.celrep.2022.110852.

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    2022-11-12 杨海东

    坚持学习

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    2022-06-22 维他命
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    2022-06-02 snowpeakxu
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    2022-05-31 杨海东

    坚持学习

    0

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