JCO:复发性卵巢癌可否从二次减瘤术时卡铂腹腔热灌注化疗中获益?

2021-05-28 Nebula MedSci原创

复发性卵巢癌可否从二次减瘤术时卡铂腹腔热灌注化疗中获益?

2021年,美国预计新增21,410例卵巢癌,而且约13,770位女性死于卵巢癌。

本研究旨在评估复发性卵巢癌患者在二次减瘤手术期中进行卡铂腹腔热灌注化疗(HIPEC)的疗效

98位受试患者术中随机接受卡铂HIPEC(HIPEC组,800 mg/m2,持续90分钟)或不接受HIPEC(标准治疗组),术后分别进行5个或6个周期的以卡铂为基础的静脉化疗。基于二项单阶段选择优胜者设计,如果某组49位患者中有17位及以上患者在术后24个月无疾病进展则被认为是优胜者。次要指标包括术后毒性和HIPEC药代动力学。

共98位患者,两组各49位。HIPEC组82%的患者和标准治疗组94%的患者实现了全部切除。HIPEC组37%的患者进行了肠切除,而标准治疗组有65%的患者进行了肠切除(p=0.008)。

无围手术期死亡病例,两组间造瘘术的使用、住院时间或术后毒性没有差异。24个月时,HIPEC组有8位患者(16.3%;单侧90% CI 9.7-100) 病程未进展或死亡,而标准治疗组有12位(24.5%;单侧90% CI 16.5 - 100)。

两组的PFS和OS

中期随访39.5个月,共有82位患者发生进展,37位死亡。HIPEC组和标准治疗组的中位无进展生存期分别为12.3个月和15.7个月(风险比 1.54; 95% CI 1 - 2.37;p=0.05);中位总生存期分别为52.5个月和59.7个月(风险比 1.39;95% CI 0.73-2.67;p=0.31)。

总之,采用卡铂进行腹腔热灌注化疗在复发性卵巢癌患者中的耐受性较好,但没有产生较好的临床预后。因此,本研究不支持在铂敏感的复发性卵巢癌的二次减瘤手术中使用卡铂腹腔热灌注化疗。

原始出处:

Oliver Zivanovic, et al. Secondary Cytoreduction and Carboplatin Hyperthermic Intraperitoneal Chemotherapy for Platinum-Sensitive Recurrent Ovarian Cancer: An MSK Team Ovary Phase II Study. Journal of Clinical Oncology. May 21, 2021. https://doi.org/10.1200/JCO.21.00605

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1737698, encodeId=8cf11e3769825, content=<a href='/topic/show?id=292f965e5b5' target=_blank style='color:#2F92EE;'>#铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96575, encryptionId=292f965e5b5, topicName=铂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca4034296500, createdName=ms3153534357578991, createdTime=Thu Oct 14 04:28:27 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909899, encodeId=76001909899d7, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Apr 10 12:28:27 CST 2022, time=2022-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1891660, encodeId=e884189166050, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Sun Apr 17 01:28:27 CST 2022, time=2022-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349635, encodeId=ac9513496358e, content=<a href='/topic/show?id=b97d425286c' target=_blank style='color:#2F92EE;'>#复发性卵巢癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42528, encryptionId=b97d425286c, topicName=复发性卵巢癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sun May 30 07:28:27 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396310, encodeId=bde8139631099, content=<a href='/topic/show?id=9dc636545a4' target=_blank style='color:#2F92EE;'>#卡铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36545, encryptionId=9dc636545a4, topicName=卡铂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun May 30 07:28:27 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506843, encodeId=8e4415068433f, content=<a href='/topic/show?id=73728559913' target=_blank style='color:#2F92EE;'>#腹腔热灌注化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85599, encryptionId=73728559913, topicName=腹腔热灌注化疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80c79828928, createdName=huangshifeng, createdTime=Sun May 30 07:28:27 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=969248, encodeId=91a496924849, content=很棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210528/5918fc0bbc774ae188a64a22b6399c0b/1df366e3903048cab4e1e94c35d32542.jpg, createdBy=6e495465029, createdName=ms2000000746519955, createdTime=Fri May 28 16:34:19 CST 2021, time=2021-05-28, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1737698, encodeId=8cf11e3769825, content=<a href='/topic/show?id=292f965e5b5' target=_blank style='color:#2F92EE;'>#铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96575, encryptionId=292f965e5b5, topicName=铂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca4034296500, createdName=ms3153534357578991, createdTime=Thu Oct 14 04:28:27 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909899, encodeId=76001909899d7, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Apr 10 12:28:27 CST 2022, time=2022-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1891660, encodeId=e884189166050, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Sun Apr 17 01:28:27 CST 2022, time=2022-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349635, encodeId=ac9513496358e, content=<a href='/topic/show?id=b97d425286c' target=_blank style='color:#2F92EE;'>#复发性卵巢癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42528, encryptionId=b97d425286c, topicName=复发性卵巢癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sun May 30 07:28:27 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396310, encodeId=bde8139631099, content=<a href='/topic/show?id=9dc636545a4' target=_blank style='color:#2F92EE;'>#卡铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36545, encryptionId=9dc636545a4, topicName=卡铂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun May 30 07:28:27 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506843, encodeId=8e4415068433f, content=<a href='/topic/show?id=73728559913' target=_blank style='color:#2F92EE;'>#腹腔热灌注化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85599, encryptionId=73728559913, topicName=腹腔热灌注化疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80c79828928, createdName=huangshifeng, createdTime=Sun May 30 07:28:27 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=969248, encodeId=91a496924849, content=很棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210528/5918fc0bbc774ae188a64a22b6399c0b/1df366e3903048cab4e1e94c35d32542.jpg, createdBy=6e495465029, createdName=ms2000000746519955, createdTime=Fri May 28 16:34:19 CST 2021, time=2021-05-28, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1737698, encodeId=8cf11e3769825, content=<a href='/topic/show?id=292f965e5b5' target=_blank style='color:#2F92EE;'>#铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96575, encryptionId=292f965e5b5, topicName=铂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca4034296500, createdName=ms3153534357578991, createdTime=Thu Oct 14 04:28:27 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909899, encodeId=76001909899d7, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Apr 10 12:28:27 CST 2022, time=2022-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1891660, encodeId=e884189166050, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Sun Apr 17 01:28:27 CST 2022, time=2022-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349635, encodeId=ac9513496358e, content=<a href='/topic/show?id=b97d425286c' target=_blank style='color:#2F92EE;'>#复发性卵巢癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42528, encryptionId=b97d425286c, topicName=复发性卵巢癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sun May 30 07:28:27 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396310, encodeId=bde8139631099, content=<a href='/topic/show?id=9dc636545a4' target=_blank style='color:#2F92EE;'>#卡铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36545, encryptionId=9dc636545a4, topicName=卡铂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun May 30 07:28:27 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506843, encodeId=8e4415068433f, content=<a href='/topic/show?id=73728559913' target=_blank style='color:#2F92EE;'>#腹腔热灌注化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85599, encryptionId=73728559913, topicName=腹腔热灌注化疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80c79828928, createdName=huangshifeng, createdTime=Sun May 30 07:28:27 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=969248, encodeId=91a496924849, content=很棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210528/5918fc0bbc774ae188a64a22b6399c0b/1df366e3903048cab4e1e94c35d32542.jpg, createdBy=6e495465029, createdName=ms2000000746519955, createdTime=Fri May 28 16:34:19 CST 2021, time=2021-05-28, status=1, ipAttribution=)]
    2022-04-17 lidong40
  4. [GetPortalCommentsPageByObjectIdResponse(id=1737698, encodeId=8cf11e3769825, content=<a href='/topic/show?id=292f965e5b5' target=_blank style='color:#2F92EE;'>#铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96575, encryptionId=292f965e5b5, topicName=铂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca4034296500, createdName=ms3153534357578991, createdTime=Thu Oct 14 04:28:27 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909899, encodeId=76001909899d7, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Apr 10 12:28:27 CST 2022, time=2022-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1891660, encodeId=e884189166050, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Sun Apr 17 01:28:27 CST 2022, time=2022-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349635, encodeId=ac9513496358e, content=<a href='/topic/show?id=b97d425286c' target=_blank style='color:#2F92EE;'>#复发性卵巢癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42528, encryptionId=b97d425286c, topicName=复发性卵巢癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sun May 30 07:28:27 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396310, encodeId=bde8139631099, content=<a href='/topic/show?id=9dc636545a4' target=_blank style='color:#2F92EE;'>#卡铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36545, encryptionId=9dc636545a4, topicName=卡铂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun May 30 07:28:27 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506843, encodeId=8e4415068433f, content=<a href='/topic/show?id=73728559913' target=_blank style='color:#2F92EE;'>#腹腔热灌注化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85599, encryptionId=73728559913, topicName=腹腔热灌注化疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80c79828928, createdName=huangshifeng, createdTime=Sun May 30 07:28:27 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=969248, encodeId=91a496924849, content=很棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210528/5918fc0bbc774ae188a64a22b6399c0b/1df366e3903048cab4e1e94c35d32542.jpg, createdBy=6e495465029, createdName=ms2000000746519955, createdTime=Fri May 28 16:34:19 CST 2021, time=2021-05-28, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1737698, encodeId=8cf11e3769825, content=<a href='/topic/show?id=292f965e5b5' target=_blank style='color:#2F92EE;'>#铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96575, encryptionId=292f965e5b5, topicName=铂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca4034296500, createdName=ms3153534357578991, createdTime=Thu Oct 14 04:28:27 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909899, encodeId=76001909899d7, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Apr 10 12:28:27 CST 2022, time=2022-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1891660, encodeId=e884189166050, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Sun Apr 17 01:28:27 CST 2022, time=2022-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349635, encodeId=ac9513496358e, content=<a href='/topic/show?id=b97d425286c' target=_blank style='color:#2F92EE;'>#复发性卵巢癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42528, encryptionId=b97d425286c, topicName=复发性卵巢癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sun May 30 07:28:27 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396310, encodeId=bde8139631099, content=<a href='/topic/show?id=9dc636545a4' target=_blank style='color:#2F92EE;'>#卡铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36545, encryptionId=9dc636545a4, topicName=卡铂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun May 30 07:28:27 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506843, encodeId=8e4415068433f, content=<a href='/topic/show?id=73728559913' target=_blank style='color:#2F92EE;'>#腹腔热灌注化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85599, encryptionId=73728559913, topicName=腹腔热灌注化疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80c79828928, createdName=huangshifeng, createdTime=Sun May 30 07:28:27 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=969248, encodeId=91a496924849, content=很棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210528/5918fc0bbc774ae188a64a22b6399c0b/1df366e3903048cab4e1e94c35d32542.jpg, createdBy=6e495465029, createdName=ms2000000746519955, createdTime=Fri May 28 16:34:19 CST 2021, time=2021-05-28, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1737698, encodeId=8cf11e3769825, content=<a href='/topic/show?id=292f965e5b5' target=_blank style='color:#2F92EE;'>#铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96575, encryptionId=292f965e5b5, topicName=铂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca4034296500, createdName=ms3153534357578991, createdTime=Thu Oct 14 04:28:27 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909899, encodeId=76001909899d7, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Apr 10 12:28:27 CST 2022, time=2022-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1891660, encodeId=e884189166050, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Sun Apr 17 01:28:27 CST 2022, time=2022-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349635, encodeId=ac9513496358e, content=<a href='/topic/show?id=b97d425286c' target=_blank style='color:#2F92EE;'>#复发性卵巢癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42528, encryptionId=b97d425286c, topicName=复发性卵巢癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sun May 30 07:28:27 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396310, encodeId=bde8139631099, content=<a href='/topic/show?id=9dc636545a4' target=_blank style='color:#2F92EE;'>#卡铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36545, encryptionId=9dc636545a4, topicName=卡铂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun May 30 07:28:27 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506843, encodeId=8e4415068433f, content=<a href='/topic/show?id=73728559913' target=_blank style='color:#2F92EE;'>#腹腔热灌注化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85599, encryptionId=73728559913, topicName=腹腔热灌注化疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80c79828928, createdName=huangshifeng, createdTime=Sun May 30 07:28:27 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=969248, encodeId=91a496924849, content=很棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210528/5918fc0bbc774ae188a64a22b6399c0b/1df366e3903048cab4e1e94c35d32542.jpg, createdBy=6e495465029, createdName=ms2000000746519955, createdTime=Fri May 28 16:34:19 CST 2021, time=2021-05-28, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1737698, encodeId=8cf11e3769825, content=<a href='/topic/show?id=292f965e5b5' target=_blank style='color:#2F92EE;'>#铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96575, encryptionId=292f965e5b5, topicName=铂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca4034296500, createdName=ms3153534357578991, createdTime=Thu Oct 14 04:28:27 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909899, encodeId=76001909899d7, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Apr 10 12:28:27 CST 2022, time=2022-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1891660, encodeId=e884189166050, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Sun Apr 17 01:28:27 CST 2022, time=2022-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349635, encodeId=ac9513496358e, content=<a href='/topic/show?id=b97d425286c' target=_blank style='color:#2F92EE;'>#复发性卵巢癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42528, encryptionId=b97d425286c, topicName=复发性卵巢癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sun May 30 07:28:27 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396310, encodeId=bde8139631099, content=<a href='/topic/show?id=9dc636545a4' target=_blank style='color:#2F92EE;'>#卡铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36545, encryptionId=9dc636545a4, topicName=卡铂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun May 30 07:28:27 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506843, encodeId=8e4415068433f, content=<a href='/topic/show?id=73728559913' target=_blank style='color:#2F92EE;'>#腹腔热灌注化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85599, encryptionId=73728559913, topicName=腹腔热灌注化疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80c79828928, createdName=huangshifeng, createdTime=Sun May 30 07:28:27 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=969248, encodeId=91a496924849, content=很棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210528/5918fc0bbc774ae188a64a22b6399c0b/1df366e3903048cab4e1e94c35d32542.jpg, createdBy=6e495465029, createdName=ms2000000746519955, createdTime=Fri May 28 16:34:19 CST 2021, time=2021-05-28, status=1, ipAttribution=)]
    2021-05-28 ms2000000746519955

    很棒

    0

相关资讯

Lancet oncol:卡巴他赛联合卡铂治疗去雄耐受性的转移性前列腺癌

在单组临床研究中,紫杉醇-铂联合治疗去势耐药的转移性前列腺癌显示出良好的活性,但尚无相关随机试验。研究人员开展一个1/2期开放性随机试验,招募进展期的去雄耐受性的转移性前列腺癌患者,评估卡巴他赛联合卡铂是否可提高这类患者的预后。1期目的是明确最大耐受剂量和剂量限制性毒性,2期评估无进展存活期。2012年8月17日-2015年5月11日,9位患者如期完成了1期试验,随后2期160位患者被随机分至卡巴

Lancet oncol:ICON8试验| 卵巢、输卵管、腹膜癌经卡铂-紫杉醇一线新辅助化疗后的客观缓解率

本文报道了ICON8试验中采用以铂类为基础的新辅助化疗继以DPS治疗的患者的RECIST和妇科恶性肿瘤协会(GCIG)CA125反应。

Lancet Oncol:Trilaciclib三联化疗方案治疗三阴性乳腺癌

研究认为,Trilaciclib、吉西他滨与卡铂联合化疗方案的骨髓抑制不良事件发生率较低,可延长三阴性乳腺癌患者生存期

Int J Clin Oncol:卡铂或西妥昔单抗加放疗对不能接受顺铂治疗的局部晚期头颈部癌症患者的安全性和有效性

头颈部局部晚期鳞状细胞癌(LASCCHN)通常采用顺铂(CDDP)为基础的化放疗,除非患者是老年人或有肾脏、心脏或神经功能障碍。本研究比较了在不符合CDDP治疗条件的患者中同时使用卡铂(CBDCA)与

Lancet:周剂量密集化疗对欧洲上皮性卵巢癌患者的疗效研究

周剂量密集化疗可以作为上皮性卵巢癌的一线治疗方法,但与欧洲主要人群的标准每3周化疗方案相比,周剂量密集化疗不能显著提高无进展生存率

J Clin Oncol:贝伐单抗+卡铂+紫杉醇可明显改善转移性粘膜黑色素瘤的预后

粘膜黑色素瘤(MM)是一种高度血管化的肿瘤,预后极差。贝伐单抗+卡铂+紫杉醇可明显改善转移性粘膜黑色素瘤的预后,一起来看看吧~