Eur Respir J:铜绿假单胞菌感染对支气管扩张症长期临床结局的独立影响!

2018-02-02 xing.T MedSci原创

由此可见,铜绿假单胞菌被发现与病情恶化、入院和生活质量较差有关。铜绿假单胞菌感染患者的死亡率增加,尤其是在频繁恶化的情况下。

铜绿假单胞菌是许多支气管扩张症患者慢性感染的病原体,但目前尚不清楚它是否独立于疾病的严重程度与患者较差的临床结局相关。近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章。

该研究分析了来自于欧洲和以色列的10个不同的支气管扩张临床中心的2596名支气管扩张症患者的数据,并对参与者进行了5年的随访。研究人员评估了铜绿假单胞菌慢性感染及其对病情加重、住院率、生活质量和死亡率的独立影响进行了评估。

铜绿假单胞菌慢性感染率为15%(n=389)。在单因素分析中,铜绿假单胞菌与较高的死亡率相关(风险比为2.02,95%可信区间为1.53-2.66,P<0.0001),但在多变量分析中没有发现对死亡率存在独立影响(风险比为0.98;95%可信区间为0.70-1.36;P=0.89)。铜绿假单胞菌仅在频繁发作(每年两次或以上)的患者中才与死亡率增加独立相关(风险比为2.03;95%可信区间为1.36-3.03;P=0.001)。在多元线性回归中,研究人员发现其与较差的生命质量7.46分(95%可信区间为2.93-12,P=0.001)独立相关。

由此可见,铜绿假单胞菌被发现与病情恶化、入院和生活质量较差有关。铜绿假单胞菌感染患者的死亡率增加,尤其是在频繁恶化的情况下。

原始出处:

David Araújo,et al. The independent contribution of Pseudomonas aeruginosa infection to long-term clinical outcomes in bronchiectasis.Eur Respir J. http://erj.ersjournals.com/content/51/2/1701953

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    2018-10-06 lsj637
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    2018-02-10 天涯183

    非常好的文章.学习了

    0

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    2018-02-04 虈亣靌

    学习了.谢谢作者分享!

    0

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