全球改善结肠镜检查结果的口服药物Methylene Blue MMX,在欧洲获批

2020-08-22 MedSci原创 MedSci原创

与HDWL结肠镜检查相比,Methylene Blue MMX组的腺瘤检出率(ADR)更高(分别为56.29%和47.81%)。

Cosmo Pharmaceuticals宣布,欧洲委员会(EC)已批准其甲硫酰氯化物Cosmo缓释片剂(Methylene Blue MMX)用于结肠镜检查中结直肠病变的可视化。这是Methylene Blue MMX的首次批准,也是口服药物改善结肠镜检查结果的首次批准。

图片来源:Repici A, Wallace MB, East JE, et al. Efficacy of Per-oral Methylene Blue Formulation for Screening Colonoscopy. Gastroenterology. 2019;156(8):2198-2207.e1.

此次批准基于Cosmo在全球20个地区进行的单项III期试验数据(涉及1249名患者)。该研究达到了预先设定的终点:与HDWL结肠镜检查相比,Methylene Blue MMX组的腺瘤检出率(ADR)更高(分别为56.29%和47.81%)。

预先指定的重要次要终点显示,与HDWL结肠镜检查相比,Methylene Blue MMX可以增加对至少一种腺瘤患者的检测,并且不会增加假阳性率(FPR)。其他终点显示,Methylene Blue MMX显著升高了对非息肉样(扁平)病变的检测(最常漏诊的病变)。

图片来源:https://www.medscape.org/noscan/slideshow/895677

CHMP建议批准Methylene Blue MMX用作“ 在接受筛查或结肠镜检查的成年患者中,增强大肠病变可视化的诊断剂”。

原始出处:

https://www.firstwordpharma.com/node/1751395?tsid=4

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createdName=JR19860219, createdTime=Thu Feb 25 06:25:06 CST 2021, time=2021-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1923732, encodeId=27fd1923e3213, content=<a href='/topic/show?id=093b353eed' target=_blank style='color:#2F92EE;'>#blue#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3537, encryptionId=093b353eed, topicName=blue)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sun Jan 10 16:25:06 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1998581, encodeId=b63519985816f, content=<a href='/topic/show?id=b2b66251e52' target=_blank style='color:#2F92EE;'>#检查结果#</a>, beContent=null, 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content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Thu Aug 27 18:43:25 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434510, encodeId=3ee51434510f4, content=<a href='/topic/show?id=95de81e4889' target=_blank style='color:#2F92EE;'>#肠镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81748, encryptionId=95de81e4889, topicName=肠镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Mon Aug 24 07:25:06 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339349, encodeId=93e413393494a, content=<a 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createdBy=f64a5412720, createdName=ms7000000689223974, createdTime=Sun Aug 23 20:05:50 CST 2020, time=2020-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812449, encodeId=2fac8124495f, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/9484c971e5f44f9eaff769f5ce71ddcf/814572c1f5654774a44e07ea1a22187d.jpg, createdBy=63e35409263, createdName=ms美霖, createdTime=Sun Aug 23 17:58:26 CST 2020, time=2020-08-23, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1896731, encodeId=8eef1896e3135, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Fri Sep 11 12:25:06 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1910392, encodeId=151e1910392d1, content=<a href='/topic/show?id=d7cd38234fc' target=_blank style='color:#2F92EE;'>#口服药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38234, encryptionId=d7cd38234fc, topicName=口服药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20b5274, createdName=JR19860219, createdTime=Thu Feb 25 06:25:06 CST 2021, time=2021-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1923732, encodeId=27fd1923e3213, content=<a href='/topic/show?id=093b353eed' target=_blank style='color:#2F92EE;'>#blue#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3537, encryptionId=093b353eed, topicName=blue)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sun Jan 10 16:25:06 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1998581, encodeId=b63519985816f, content=<a href='/topic/show?id=b2b66251e52' target=_blank style='color:#2F92EE;'>#检查结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62517, encryptionId=b2b66251e52, topicName=检查结果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c6fc262, createdName=zhangmingxiang, createdTime=Mon Nov 23 09:25:06 CST 2020, time=2020-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2060865, encodeId=9b6020608653b, content=<a href='/topic/show?id=49f63823396' target=_blank style='color:#2F92EE;'>#口服药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38233, encryptionId=49f63823396, topicName=口服药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ed25376, createdName=gdsun, createdTime=Fri Oct 23 17:25:06 CST 2020, time=2020-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814225, encodeId=5c2d81422567, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Thu Aug 27 18:43:25 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434510, encodeId=3ee51434510f4, content=<a href='/topic/show?id=95de81e4889' target=_blank style='color:#2F92EE;'>#肠镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81748, encryptionId=95de81e4889, topicName=肠镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Mon Aug 24 07:25:06 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339349, encodeId=93e413393494a, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Mon Aug 24 07:25:06 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812510, encodeId=c48581251082, content=讲的很详细,很有用,赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200823/ece0a24ea5824924b9ba0b87a5947f86/11f20d29045c49fd9671ef69fa0c4012.jpg, createdBy=f64a5412720, createdName=ms7000000689223974, createdTime=Sun Aug 23 20:05:50 CST 2020, time=2020-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812449, encodeId=2fac8124495f, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/9484c971e5f44f9eaff769f5ce71ddcf/814572c1f5654774a44e07ea1a22187d.jpg, createdBy=63e35409263, createdName=ms美霖, createdTime=Sun Aug 23 17:58:26 CST 2020, time=2020-08-23, status=1, ipAttribution=)]
    2020-10-23 gdsun
  6. [GetPortalCommentsPageByObjectIdResponse(id=1896731, encodeId=8eef1896e3135, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Fri Sep 11 12:25:06 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1910392, encodeId=151e1910392d1, content=<a href='/topic/show?id=d7cd38234fc' target=_blank style='color:#2F92EE;'>#口服药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38234, encryptionId=d7cd38234fc, topicName=口服药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20b5274, 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href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Mon Aug 24 07:25:06 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812510, encodeId=c48581251082, content=讲的很详细,很有用,赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200823/ece0a24ea5824924b9ba0b87a5947f86/11f20d29045c49fd9671ef69fa0c4012.jpg, createdBy=f64a5412720, createdName=ms7000000689223974, createdTime=Sun Aug 23 20:05:50 CST 2020, time=2020-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812449, encodeId=2fac8124495f, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/9484c971e5f44f9eaff769f5ce71ddcf/814572c1f5654774a44e07ea1a22187d.jpg, createdBy=63e35409263, createdName=ms美霖, createdTime=Sun Aug 23 17:58:26 CST 2020, time=2020-08-23, status=1, ipAttribution=)]
    2020-08-27 14818eb4m67暂无昵称

    学习了

    0

  7. 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createdBy=f64a5412720, createdName=ms7000000689223974, createdTime=Sun Aug 23 20:05:50 CST 2020, time=2020-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812449, encodeId=2fac8124495f, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/9484c971e5f44f9eaff769f5ce71ddcf/814572c1f5654774a44e07ea1a22187d.jpg, createdBy=63e35409263, createdName=ms美霖, createdTime=Sun Aug 23 17:58:26 CST 2020, time=2020-08-23, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1896731, encodeId=8eef1896e3135, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Fri Sep 11 12:25:06 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1910392, encodeId=151e1910392d1, content=<a href='/topic/show?id=d7cd38234fc' target=_blank style='color:#2F92EE;'>#口服药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38234, encryptionId=d7cd38234fc, topicName=口服药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20b5274, 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createdBy=f64a5412720, createdName=ms7000000689223974, createdTime=Sun Aug 23 20:05:50 CST 2020, time=2020-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812449, encodeId=2fac8124495f, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/9484c971e5f44f9eaff769f5ce71ddcf/814572c1f5654774a44e07ea1a22187d.jpg, createdBy=63e35409263, createdName=ms美霖, createdTime=Sun Aug 23 17:58:26 CST 2020, time=2020-08-23, status=1, ipAttribution=)]
  9. 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createdBy=f64a5412720, createdName=ms7000000689223974, createdTime=Sun Aug 23 20:05:50 CST 2020, time=2020-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812449, encodeId=2fac8124495f, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/9484c971e5f44f9eaff769f5ce71ddcf/814572c1f5654774a44e07ea1a22187d.jpg, createdBy=63e35409263, createdName=ms美霖, createdTime=Sun Aug 23 17:58:26 CST 2020, time=2020-08-23, status=1, ipAttribution=)]
    2020-08-23 ms7000000689223974

    讲的很详细,很有用,赞一个

    0

  10. 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content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Thu Aug 27 18:43:25 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434510, encodeId=3ee51434510f4, content=<a href='/topic/show?id=95de81e4889' target=_blank style='color:#2F92EE;'>#肠镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81748, encryptionId=95de81e4889, topicName=肠镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Mon Aug 24 07:25:06 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339349, encodeId=93e413393494a, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Mon Aug 24 07:25:06 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812510, encodeId=c48581251082, content=讲的很详细,很有用,赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200823/ece0a24ea5824924b9ba0b87a5947f86/11f20d29045c49fd9671ef69fa0c4012.jpg, createdBy=f64a5412720, createdName=ms7000000689223974, createdTime=Sun Aug 23 20:05:50 CST 2020, time=2020-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812449, encodeId=2fac8124495f, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/9484c971e5f44f9eaff769f5ce71ddcf/814572c1f5654774a44e07ea1a22187d.jpg, createdBy=63e35409263, createdName=ms美霖, createdTime=Sun Aug 23 17:58:26 CST 2020, time=2020-08-23, status=1, ipAttribution=)]
    2020-08-23 ms美霖

    👍

    0

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结肠镜检查对大多数中危腺瘤患者有益,然而对于结肠镜检查后低风险患者,定期检查的价值目前还不清楚

2020 USMSTF共识:结肠镜检查及息肉切除术后随访建议

2020年2月,美国结直肠癌多学会工作组(USMSTF)更新发布了结肠镜检查及息肉切除术后随访共识建议。结肠镜检查常规用于结直肠癌筛查、随访以及胃肠道疾病的检查和结直肠癌切除术后监测。本文是对2012年USMSTF相应共识建议的更新,主要目的是回顾最新证据更新随访建议。

BMJ:结肠镜检查后出现肠道穿孔-病例报道

CT显示腹部存在游离空气,这是肠穿孔的指标。可以看到近期用于内镜下息肉切除的钛夹,并表明是最有可能的穿孔点。

Am J Gastroenterol:视频饮食教育能改善肠道准备质量吗?

门诊结肠镜检查(CLS)能否成功取决于许多因素,包括患者的肠道准备情况。虽然CLS之前服用导泻剂可以提高肠道准备质量,但没有研究评估CLS之前饮食教育对CLS质量的影响。 我们创立了CLS之前的饮食教育视频,调查这项措施能否改善患者的肠道准备质量。 这项前瞻性随机试验使用聚乙二醇基进行肠道准备。然后将患者随机分配到干预组或无干预组。干预为4分钟的教育视频,详细说明了明确的液体饮食限制。

2018 WEO共识声明:结肠镜检查后以及影像检查后结直肠癌

2018年6月,世界内镜组织(WEO)发布了结肠镜检查后以及影像检查后结直肠癌指南,结肠镜检查并不是总能发现胰腺癌,一些患者在检查阴性后进展为结直肠癌。本文主要针对结肠镜检查后以及影像检查后结直肠癌的相关内容提出21条共识声明。

Sci Rep:结肠镜检查中的肠道准备能够减少睾酮水平

尽管结肠镜检查在韩国的医疗体检中经常进行,而肠道准备对各种不同健康状况影响的调查还不充分。最近,有研究人员进行了代表性的研究来调查是否肠道准备对血清中睾酮的水平具有影响。研究包括了1114名男性,分为肠道准备组和对照组。研究发现,总的和自由睾酮均值在肠道准备组中均比对照组(分别为15.72和0.28 nmol/L)显著更低(分别为14.89和0.26?nmol/L)。在肠道准备组中,总睾酮的水平随