BMJ:PM2.5与中国心血管疾病患者住院风险

2020-01-03 MedSci MedSci原创

研究发现, PM2.5与除出血性脑卒中以外的所有心血管疾病入院相关,即使PM2.5处于较低水平该相关性仍然显著

近日研究人员评估了中国人群中与PM2.5相关的心血管住院风险。

研究人员考察了中国国家城镇职工基本医疗保险数据库数据,涉及184个城市,因心血管原因住院的8834533例病例。心血管疾病包含缺血性心脏病、心力衰竭、心律紊乱、缺血性脑卒中和出血性脑卒中。

在研究期间,心血管疾病平均每天入院47例,其中缺血性心脏病26例,心力衰竭1例,心律失常2例,缺血性中风14例,出血性中风2例。在全国平均水平上,PM2.5每增加10 μg/m3导致当日心血管疾病住院人数增加0.26%,缺血性心脏病住院增加0.31%,心力衰竭住院增加0.27%,心律失常住院增加0.29%,缺血性中风住院增加0.29%,但出血性中风住院未见显著变化(-0.02%)。全国PM2.5水平与心血管疾病的平均关联度为轻度非线性,分为50 μg/m3以下、50-250 μg/m35以及高于250 μg/m3三个区间。与PM2.5 15μg/m3相比,PM2.5浓度为15-25、25-35、35-75和75μg/m3或更高的时间段,患者心血管疾病入院率分别增加1.1%、1.9%、2.6%和3.8%。根据预测,若达到中国2级(35 μg/m3)、中国1级(15 μg/m3)和世界卫生组织 (10 μg/m3)的年平均PM2.5限值,将减少中国每年因心血管疾病入院的人数,分别为36448例、85270例和97516例。

研究发现, PM2.5与除出血性脑卒中以外的所有心血管疾病入院相关,即使PM2.5处于较低水平该相关性仍然显著。

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    2020-02-12 gaoxiaoe
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