J INTERN MED:全身炎症是牙周炎与高血压之间的中间环节吗?

2020-10-03 MedSci原创 MedSci原创

近日,内科学领域权威杂志Journal of Internal Medicine上发表一篇研究文章,该研究的主要目标是通过两个独立的大型调查研究旨在探究牙周炎与高血压之间的关系。该研究的次要目的是明确

近日,内科学领域权威杂志Journal of Internal Medicine上发表一篇研究文章,该研究的主要目标是通过两个独立的大型调查研究旨在探究牙周炎与高血压之间的关系。该研究的次要目的是明确全身性炎症在这种关联中是否具有介导作用。

这项横断面研究分析了美国(n=3460;NHANES 2009/10)和韩国(n=4539; 2015 KNHANES VI-3)人群的代表性样本。研究人员使用多元线性和Logistic回归模型和介导分析,评估了牙周炎(暴露因素)、高血压(结局)和炎性标志物[C反应蛋白(CRP)和白细胞计数(WBC)](介导因素)之间的关联。

研究人员发现牙周炎患者更有可能患有高血压(NHANES:OR=1.3,95%CI:1.0-1.6,p=0.025; KNHANES:OR=1.2,95%CI:1.0-1.4,p=0.041),并且收缩期压≥140mmHg(NHANES:OR=1.6,95%CI:1.1-2.3,p<0.001; KNHANES:OR=1.3,95%CI:1.0-1.6,p<0.031)。这些关联与年龄、性别、BMI、教育程度、吸烟、饮酒、肌酐、身体活动、其他合并症无关,并且在未服用降压药的参与者中得到证实。牙周炎的诊断与WBC(两项调查均直接相关,NHANES:β±SE=0.3±0.1,p<0.004; KNHANES:β±SE=0.3±0.1,p<0.001)和CRP水平(一项调查: NHANES:β±SE=0.1±0.03,p<0.007; KNHANES:β±SE=0.1±0.04,p>0.213)直接相关。介导分析证实,在两个人群中CRP均作为牙周炎和高血压之间的介导因素(介导作用:NHANES:β±SE=0.010±0.003,p<0.001;KNHANES:β±SE=0.003±0.001,p=0.015)。

由此可见,牙周炎与高血压密切相关,而全身性炎症在某种程度上是这种关联的介导因素。

原始出处:

Eva Muñoz Aguilera.et al.Is Systemic Inflammation a Missing Link Between Periodontitis and Hypertension? Results from Two Large Populations‐based Surveys.J INTERN MED.2020.https://onlinelibrary.wiley.com/doi/10.1111/joim.13180

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    牙周炎和脑卒中和高血压都有关系??好神奇,这个想法是怎么捕捉到的?

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