Anaesthesia:剖宫产术中脊髓麻醉过程中给予血管抑制剂可预防低血压的发生

2020-08-20 MedSci原创 MedSci原创

剖腹产脊髓麻醉通常会导致产妇低血压。本系统性回顾和网络荟萃分析比较了预防剖宫产脊髓麻醉产妇低血压的方法。

剖腹产脊髓麻醉通常会导致产妇低血压。本系统性回顾和网络荟萃分析比较了预防剖宫产脊髓麻醉产妇低血压的方法。

通过搜索MEDLINE和Embase、Web of Science至2018年12月,研究人员选择了比较预防低血压的干预措施与另一干预措施或无效对照措施的随机对照试验。没有语言限制。两位审稿人提取了试验特征、方法和结果的数据。评估了单个试验的偏倚风险(Cochrane工具)和证据质量(GRADE检查表)。

 

最终研究人员评估了109项试验(8561名女性)和12种不同的方法,进行了30项直接比较。按OR(95%CI)从最有效到最无效的方法排序为:甲胺醇0.11(0.04-0.26);去甲肾上腺素0.13(0.06-0.28);苯肾上腺素0.18(0.11-0.29);腿部压迫0.25(0.14-0.43);麻黄碱0.28(0.18-0.43);麻醉诱导前给予胶体0. 38(0.24-0.61);血管紧张素2,0.12(0.02-0.75);麻醉诱导后给予胶体0.52(0.30-0.90);甲氧苄啶0.09(0.01-1.30);麻醉诱导后给予晶体0.78(0.46-1.31);麻醉诱导前给予晶体1.16(0.76-1.79)。与对照组相比,去氧肾上腺素引起产妇心动过缓,OR(95%CI)0.23(0.07-0.79)。麻黄碱比去氧肾上腺素更能降低脐动脉pH值,标准化平均差异(95%CI)0.78(0.47-1.49)。

综上所述,该分析结果表明,健康女性在脊柱麻醉的剖宫产过程中,应给予血管抑制剂预防低血压。

 

原始出处:

 

J P FitzgeraldK A Fedoruk, et al., Prevention of hypotension after spinal anaesthesia for caesarean section: a systematic review and network meta-analysis of randomised controlled trials. Anaesthesia. 2020 Jan;75(1):109-121. doi: 10.1111/anae.14841. 

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    2021-01-30 ms4000001548147119

    这毕竟只是回顾和荟萃分析,临床使用血管抑制剂有没有明显副作用也要考虑

    0

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    2021-07-13 jklm09
  5. [GetPortalCommentsPageByObjectIdResponse(id=921459, encodeId=b6a192145942, content=这毕竟只是回顾和荟萃分析,临床使用血管抑制剂有没有明显副作用也要考虑, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=59e65457043, createdName=ms4000001548147119, createdTime=Sat Jan 30 21:40:19 CST 2021, time=2021-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051597, encodeId=955c205159ecf, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Feb 17 05:07:34 CST 2021, time=2021-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1687064, encodeId=34df168e0645e, content=<a href='/topic/show?id=eb25846510b' target=_blank style='color:#2F92EE;'>#脊髓麻醉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84651, encryptionId=eb25846510b, topicName=脊髓麻醉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ee028313888, createdName=膀胱癌, createdTime=Tue Sep 22 09:07:34 CST 2020, time=2020-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1852464, encodeId=6e4e18524647c, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Tue Jul 13 20:07:34 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1633590, encodeId=529f16335909f, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Sat Nov 28 22:07:34 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1367411, encodeId=9fe7136e411ba, content=<a href='/topic/show?id=f4012634656' target=_blank style='color:#2F92EE;'>#低血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26346, encryptionId=f4012634656, topicName=低血压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Sat Aug 22 09:07:34 CST 2020, time=2020-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588445, encodeId=ff8d158844525, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Sat Aug 22 09:07:34 CST 2020, time=2020-08-22, status=1, ipAttribution=)]
    2020-11-28 AspirantSuo
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    2020-08-22 skhzy

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