Neurology:补充维生素 D 可预防良性阵发性位置性眩晕

2021-07-23 MedSci原创 MedSci原创

近日,一项研究者发起的、盲法结果评估者、平行、多中心、随机对照试验评估了维生素 D 和钙补充剂在预防良性阵发性位置性眩晕 (BPPV) 复发方面的作用,研究结果已发表于Neurology。

近日,一项研究者发起的、盲法结果评估者、平行、多中心、随机对照试验评估了维生素 D 和钙补充剂在预防良性阵发性位置性眩晕 (BPPV) 复发方面的作用,研究结果已发表于Neurology。

该研究在 2013 年 12 月至 2017 年 5 月期间在 8 家医院进行,纳入确诊 BPPV 的患者,随机分配到干预(n = 518)或观察( n = 532) 组。主要结果是年复发率(ARR)。干预组患者在血清维生素 D 水平低于 20 ng/mL 时每天服用两次维生素 D 400 IU 和 500 mg 碳酸钙,持续 1 年。观察组的患者分配到随访中,没有进一步评估或补充维生素 D。

 

结果显示,干预组 ARR 降低(0.83 [95% CI,0.74-0.92] vs 1.10 [95% CI,1.00-1.19] 复发/1人年),从意向性治疗分析来看,发病率比为0.76(95% CI,0.66-0.87,p < 0.001),绝对比率为 -0.27(-0.40 至 -0.14)。需要治疗的人数为 3.70(95% CI,2.50-7.14)。干预组中复发患者的比例也低于观察组(37.8% vs 46.7%,p = 0.005)。

 

综上, 频繁发作的BPPV患者可考虑补充维生素 D 和钙,尤其是当血清维生素 D 低于正常水平时。

 

原始出处:

 

Seong-Hae Jeong, et al.,Prevention of benign paroxysmal positional vertigo with vitamin D supplementation: A randomized trial. Neurology. 2020 Sep 1;95(9):e1117-e1125. doi: 10.1212/WNL.0000000000010343.  

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    2022-06-12 yinhl1978
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