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Heart：ApoCIII-Lp（a）复合物与Lp（a）-OxPL联合可以预测主动脉瓣狭窄的快速进展

2020-03-04 xiangting MedSci原创

载脂蛋白CIII主动脉瓣狭窄OxPL-apo（a）载脂蛋白进展
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ApoC-III存在于Lp（a）和主动脉瓣小叶中。与Lp（a）结合的ApoCIII-Lp（a）复合物、OxPL-apoB或OxPL-apo（a）水平升高可以识别AS进展快速和AVR/心源性死亡率高的轻-中度AS患者。

这项研究评估了载脂蛋白CIII-脂蛋白（a）复合物（ApoCIII-Lp（a））是否与钙化主动脉瓣狭窄（AS）的进展相关。

对68例小叶病理分级1-4级患者的切除主动脉瓣小叶进行ApoC-III免疫染色。测定来自AS进展性观察：瑞舒伐他汀疗效评估试验（ASTRONOMER）的218例轻-中度AS患者的循环ApoCIII-Lp（a）复合物水平。确定以峰值主动脉射流速度（Vpeak）年度变化来衡量的AS进展率，以及主动脉瓣置换（AVR）和心源性死亡的合并率。为了进一步证实测定数据，对纯化的Lp（a）进行了蛋白质组学分析，以确认Lp（a）上是否存在apoC-III。

免疫组化检测到所有小叶病变严重性分级中均明显存在ApoC-III。ApoCIII-Lp（a）与Lp（a）、载脂蛋白B-100的氧化磷脂（OxPL-apoB）或载脂蛋白（a）的氧化磷脂（OxPL-apo（a））与年化Vpeak之间存在明显相互作用（p均<0.05）。经过多因素调整后，apoCIII-Lp（a）和Lp（a）均处于最高三分位的患者年化Vpeak（p<0.001）和AVR/心源性死亡的风险明显升高（p=0.03）。OxPL-apoB和OxPL-apo（a）的结果相似。ApoB的自分泌运动因子（ATX）和Lp（a）的ATX与AS病情进展较快之间没有关联。纯化Lp（a）的蛋白质组学分析表明apoC-III主要存在于Lp（a）上。

ApoC-III存在于Lp（a）和主动脉瓣小叶中。与Lp（a）结合的ApoCIII-Lp（a）复合物、OxPL-apoB或OxPL-apo（a）水平升高可以识别AS进展快速和AVR/心源性死亡率高的轻-中度AS患者。

原始出处：

Romain Capoulade. ApoCIII-Lp(a) complexes in conjunction with Lp(a)-OxPL predict rapid progression of aortic stenosis. Heart. 26 February 2020.

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    2021-01-01 juliusluan78

    #III#

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    2020-03-20 yang0210

    #复合物#

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    2020-03-06 hittouch

    #主动脉瓣#

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    2020-03-06 zhaojie88

    #ART#

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    2020-03-06 circumcision

    #主动脉#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1916239, encodeId=966a19162392b, content=<a href='/topic/show?id=c5a89550ff' target=_blank style='color:#2F92EE;'>#III#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9550, encryptionId=c5a89550ff, topicName=III)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e68e415, createdName=juliusluan78, createdTime=Fri Jan 01 00:09:00 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1910656, encodeId=b781191065618, content=<a href='/topic/show?id=b45b426195e' target=_blank style='color:#2F92EE;'>#复合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42619, encryptionId=b45b426195e, topicName=复合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad7f282, createdName=yang0210, createdTime=Fri Mar 20 23:09:00 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332720, encodeId=1b161332e2014, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Fri Mar 06 04:09:00 CST 2020, time=2020-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357422, encodeId=33da135e4228c, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 06 04:09:00 CST 2020, time=2020-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415627, encodeId=bc03141562e55, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Fri Mar 06 04:09:00 CST 2020, time=2020-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563247, encodeId=693b156324ec5, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Mar 06 04:09:00 CST 2020, time=2020-03-06, status=1, ipAttribution=)]
    2020-03-06 slcumt

    #HEART#

    0

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