JCEM:多囊卵巢综合征妇女高血压的发病率和预测因素

2021-03-22 MedSci原创 MedSci原创

PCOS患者更可能在成年后发展为高血压,而与BMI无关,肥胖会进一步加重病情。在高血压风险分层评估中纳入PCOS可能有助于尽早发现该疾病。

在以人群为基础的大型研究中,针对多囊卵巢综合征(PCOS)与高血压之间关系的研究十分有限。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在评估15年来有无PCOS的女性中高血压的发生率。

该研究是对来自澳大利亚妇女健康纵向研究的纵向数据进行的二次分析。参与者为从国家健康保险数据库中随机选择的年龄在21-42岁之间的女性,她们被随访至2000年与2015年间。

研究人员使用Cox比例风险模型进行了生存分析,以识别高血压的预测因素,并进行了人群-时间分析以计算高血压的发病率。

9508名女性进行了145159人次每年(PY)的随访,1556名(16.37%)女性在随访期间发生了高血压。患有PCOS的女性(17/1000 PY)的高血压发病率显著高于未患有PCOS的女性(10/1000 PY)。8223名女性PCOS状态已知,其中681名女性(8.3%)有自我报告的PCOS。与年龄相匹配的瘦弱PCOS妇女相比,肥胖的PCOS妇女高血压发病率高出四倍(分别为15.8和4.3/1000PY)。PCOS与高血压风险高37%(HR为1.37,95%CI为1.14-1.65)相关,在调整体重指数(BMI)、高血压家族史、职业和2型糖尿病合并症后。

由此可见,PCOS患者更可能在成年后发展为高血压,而与BMI无关,肥胖会进一步加重病情。在高血压风险分层评估中纳入PCOS可能有助于尽早发现该疾病

原始出处:

Anju E Joham.et al.Incidence and Predictors of Hypertension in a Cohort of Australian Women with and without Polycystic Ovary Syndrome.JCEM.2021.https://pubmed.ncbi.nlm.nih.gov/33693653/

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content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sun Oct 24 11:13:56 CST 2021, time=2021-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264357, encodeId=f5e5126435e10, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Wed Mar 24 12:13:56 CST 2021, time=2021-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1432030, encodeId=83ac143203001, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Mar 24 12:13:56 CST 2021, time=2021-03-24, status=1, ipAttribution=)]
    2021-08-08 yxh20210801

    学习了

    0

  5. 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createdName=yxh20210801, createdTime=Sun Aug 08 15:10:14 CST 2021, time=2021-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950265, encodeId=ae34950265c0, content=<a href='/topic/show?id=800d4315123' target=_blank style='color:#2F92EE;'>#多囊卵巢综合征#</a>妇女<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>,二者在背后可能有关!!背后原因是不是高胰岛素血症?, beContent=null, objectType=article, channel=null, level=null, likeNumber=335, replyNumber=2, topicName=null, topicId=null, topicList=[TopicDto(id=43151, encryptionId=800d4315123, topicName=多囊卵巢综合征), TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Mar 23 09:31:06 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971469, encodeId=56f09e1469da, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/KVHctYzJg2NRamomawmLicXkx2wOqTxoncJfTCraj1ff7K7gG5lr8u9wyzCUVMMW5T6JPibpuKF6OPicV5YiaWFqew/132, createdBy=65c65253420, createdName=Lee4204, createdTime=Mon Jun 07 10:22:08 CST 2021, time=2021-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=969512, encodeId=449b969512d3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411a5486928, createdName=ms4000001244815732, createdTime=Sat May 29 19:41:23 CST 2021, time=2021-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063413, encodeId=36ab206341389, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sun Oct 24 11:13:56 CST 2021, time=2021-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264357, encodeId=f5e5126435e10, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Wed Mar 24 12:13:56 CST 2021, time=2021-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1432030, encodeId=83ac143203001, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Mar 24 12:13:56 CST 2021, time=2021-03-24, status=1, ipAttribution=)]
    2021-03-23 病毒猎手

    #多囊卵巢综合征#妇女#高血压#,二者在背后可能有关!!背后原因是不是高胰岛素血症?

    2

    展开2条回复
  6. 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createdName=yxh20210801, createdTime=Sun Aug 08 15:10:14 CST 2021, time=2021-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950265, encodeId=ae34950265c0, content=<a href='/topic/show?id=800d4315123' target=_blank style='color:#2F92EE;'>#多囊卵巢综合征#</a>妇女<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>,二者在背后可能有关!!背后原因是不是高胰岛素血症?, beContent=null, objectType=article, channel=null, level=null, likeNumber=335, replyNumber=2, topicName=null, topicId=null, topicList=[TopicDto(id=43151, encryptionId=800d4315123, topicName=多囊卵巢综合征), TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Mar 23 09:31:06 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971469, encodeId=56f09e1469da, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/KVHctYzJg2NRamomawmLicXkx2wOqTxoncJfTCraj1ff7K7gG5lr8u9wyzCUVMMW5T6JPibpuKF6OPicV5YiaWFqew/132, createdBy=65c65253420, createdName=Lee4204, createdTime=Mon Jun 07 10:22:08 CST 2021, time=2021-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=969512, encodeId=449b969512d3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411a5486928, createdName=ms4000001244815732, createdTime=Sat May 29 19:41:23 CST 2021, time=2021-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063413, encodeId=36ab206341389, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sun Oct 24 11:13:56 CST 2021, time=2021-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264357, encodeId=f5e5126435e10, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Wed Mar 24 12:13:56 CST 2021, time=2021-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1432030, encodeId=83ac143203001, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Mar 24 12:13:56 CST 2021, time=2021-03-24, status=1, ipAttribution=)]
    2021-06-07 Lee4204

    0

  7. 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content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sun Oct 24 11:13:56 CST 2021, time=2021-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264357, encodeId=f5e5126435e10, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Wed Mar 24 12:13:56 CST 2021, time=2021-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1432030, encodeId=83ac143203001, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Mar 24 12:13:56 CST 2021, time=2021-03-24, status=1, ipAttribution=)]
    2021-05-29 ms4000001244815732

    学习了

    0

  8. 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content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sun Oct 24 11:13:56 CST 2021, time=2021-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264357, encodeId=f5e5126435e10, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Wed Mar 24 12:13:56 CST 2021, time=2021-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1432030, encodeId=83ac143203001, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Mar 24 12:13:56 CST 2021, time=2021-03-24, status=1, ipAttribution=)]
    2021-10-24 achengzhao
  9. 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  10. 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