Dig Liver Dis:饮食中维生素E和C的摄入与非酒精性脂肪肝的严重程度成反比

2020-03-14 MedSci原创 MedSci原创

尽管抗氧化剂在非酒精性脂肪性肝病(NAFLD)和脂肪性肝炎(NASH)中具有保护潜力,但关于饮食中摄入抗氧化剂的作用的证据有限。本项研究的目的是测试饮食中维生素E和C的摄入量与NAFLD,

背景与目标:尽管抗氧化剂在非酒精性脂肪性肝病(NAFLD)和脂肪性肝炎(NASH)中具有保护潜力,但关于饮食中摄入抗氧化剂的作用的证据有限。本项研究的目的是测试饮食中维生素E和C的摄入量与NAFLD,NASH和纤维化标志物之间的关系。

方法:本项研究是一项横断面研究。研究人员通过超声检查评估患者NAFLD的存在。使用SteatoTest定义脂肪变性水平,使用新的定量NashTest定义中度重度NASH,使用FibroTest定义边缘显着性纤维化≥F1-F2。营养摄入量通过食物频率调查表(FFQ)进行测量。

结果:本项研究总共包括789名受试者(52.6%的男性,年龄58.83±6.58岁),其中714名具有可靠的随访数据。在调整了BMI,饮食和生活方式因素后,维生素E摄入量/1000 Kcal的较高三分位数与NASH的机率较低有关(OR = 0.64、0.43-0.94,P = 0.024)。达到推荐的维生素E摄入量与NASH之间存在负相关关系(OR = 0.48,0.30-0.77,P = 0.002)。维生素C摄入量/1000 Kcal的最高三分位数与NAFLD和NASH的较低几率相关(分别为OR = 0.68、0.47–0.99,P = 0.045; OR = 0.57、0.38–0.84,P = 0.004)。根据SteatoTest,两种维生素都与脂肪变性水平有关。

结论 摄入维生素E和C可以预防与NAFLD相关的肝损害。

原始出处:

Dana Ivancovsky-Wajcman. Et al. Dietary vitamin E and C intake is inversely associated with the severity of nonalcoholic fatty liver disease. Digestive and Liver Disease. 2020.

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    2020-03-15 xcdnxj

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