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Neurology：LGI-1自身免疫性脑炎患者3个不同阶段的18F-FDG-PET/SPM分析

2019-12-24 zyx 神经科病例撷英拾粹

自身免疫脑炎肌张力障碍
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50岁女性，睡眠时出现面臂肌张力障碍样发作约50天。

50岁女性，睡眠时出现面臂肌张力障碍样发作约50天（图A）。最初的MRI扫描正常，但FDG-PET可见基底节（BG）和颞叶内侧（MTL）高代谢（图B）。临床症状高度怀疑LGI-1自身免疫性脑炎的诊断，经LGI-1抗体滴度检测（血清和CSF）证实。复发后，患者再次表现为先前的PET异常模式。

LGI-1自身免疫性脑炎的早期诊断对于进一步治疗是必需的。PET上BG和MTL的代谢异常变化比MRI上病灶出现早。



（图：A：患者FBDS症状出现后的事件顺序；B：入院诊断，复发，出院和复查的3个不同时间阶段的代表性MRI和18F-FDG-PET/SPM[p <0.01]图像；BG=基底神经节；IVIg=静脉注射免疫球蛋白；IVMP=静脉注射甲强龙；MTL =颞叶内侧；VPA=丙戊酸）

原始出处：Shan W， Liu X， Wang Q. Teaching NeuroImages: 18F-FDG-PET/SPM analysis in 3 different stages from a patient with LGI-1 autoimmune encephalitis.Neurology. 2019 Nov 12；93(20)：e1917-e1918.

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    2020-06-05 xugumin

    #8F-FDG#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2024608, encodeId=e9cc2024608ec, content=<a href='/topic/show?id=5dc715e04b' target=_blank style='color:#2F92EE;'>#8F-FDG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1570, encryptionId=5dc715e04b, topicName=8F-FDG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Fri Jun 05 04:53:00 CST 2020, time=2020-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728240, encodeId=b3e91e2824001, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Feb 29 12:53:00 CST 2020, time=2020-02-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000938, encodeId=4f9d20009385c, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sat Jan 04 15:53:00 CST 2020, time=2020-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331147, encodeId=fa47133114e14, content=<a href='/topic/show?id=15e2140e438' target=_blank style='color:#2F92EE;'>#PET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5PdY90y5Jib8FnPhCXTR2d9v3K17epNSwB2eb0vmXUldNJl2e72S4unZTAHLAojicdVSialTDFHAxA/132, createdBy=78d82500042, createdName=ms7514935887898259, createdTime=Thu Dec 26 12:53:00 CST 2019, time=2019-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343595, encodeId=2dba134359579, content=<a href='/topic/show?id=928a849314c' target=_blank style='color:#2F92EE;'>#脑炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84931, encryptionId=928a849314c, topicName=脑炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/22AEC2EC4805C29C6E1DEE6D888DB41C/100, createdBy=7a322500193, createdName=ms1779634646866130, createdTime=Thu Dec 26 12:53:00 CST 2019, time=2019-12-26, status=1, ipAttribution=)]
    2020-02-29 feather89

    #PE#

    0

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    2020-01-04 hb2008ye

    #Neurol#

    0

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    2019-12-26 ms7514935887898259

    #PET#

    0

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    2019-12-26 ms1779634646866130

    #脑炎#

    0

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