Ann Fam Med:终止妊娠可提高女性心血管疾病发病风险

2014-07-22 佚名 生物谷

近日,刊登在国际杂志The Annals of Family Medicine上的一篇研究论文中,来自罗德岛纪念医院的研究人员通过研究表明,在成人期有妊娠终止历史的女性或许存在较高的心血管疾病发病风险。 文章中研究人员对有孕妇经历的77701名女性进行调查发现,其中有30.3%的个体曾经有流产的历史,2.2%的女性有死产的历史,2.2%的女性兼有流产和死产的历史。Parker教授表示,相比没

近日,刊登在国际杂志The Annals of Family Medicine上的一篇研究论文中,来自罗德岛纪念医院的研究人员通过研究表明,在成人期有妊娠终止历史的女性或许存在较高的心血管疾病发病风险。


文章中研究人员对有孕妇经历的77701名女性进行调查发现,其中有30.3%的个体曾经有流产的历史,2.2%的女性有死产的历史,2.2%的女性兼有流产和死产的历史。Parker教授表示,相比没有死产经历的女性来讲,有1次或多次死产经历的女性患冠心病的调整优势为1.27(95%的置信区间,可靠性度量在1.07-1.51之间);对于有1次流产经历的女性来讲,冠心病的调整优势比为1.19(95%的置信区间,可靠性度量在1.08-1.32);对于有两次或多次流产经历的女性来讲,这种优势比为1.18(95%的置信区间,可靠性度量在1.04-1.34)。



研究者发现缺血性脑卒中和妊娠终止之间并无明显关联,而妊娠终止和冠心病之间的关联并不依赖于个体的高血压、身体质量指数、腰臀比以及白细胞数。这项研究中,研究者通过研究指出,和妊娠终止相关的机体代谢、激素以及止血路径的改变都会引发成年期女性个体患上冠心病。

因此有妊娠终止或死胎历史的女性个体都必须进行实时监测,并进行早期干预来避免患有各种疾病的潜在风险,比如患糖尿病、高血压、肥胖,而且对于这些个体的饮食也要紧密监控。

原始出处:

Parker DR1, Lu B2, Sands-Lincoln M2, Kroenke CH2, Lee CC2, O'Sullivan M2, Park HL2, Parikh N2, Schenken RS2, Eaton CB2.Risk of Cardiovascular Disease Among Postmenopausal Women with Prior Pregnancy Loss: The Women's Health Initiative.Ann Fam Med. 2014 Jul;12(4):302-9. doi: 10.1370/afm.1668.[pdf free]

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