JACC:重度钙化性二尖瓣狭窄的自然病程

2020-06-22 MedSci原创 MedSci原创

钙化性二尖瓣狭窄(MS)的发病率随着年龄的增大而变大,然而其自然病程及其与心脏并发症的关系尚不清楚。本研究的目的旨在评估钙化性MS患者的临床症状、并发症及影响全因死亡率的因素。

钙化性二尖瓣狭窄(MS)的发病率随着年龄的增大而变大,然而其自然病程及其与心脏并发症的关系尚不清楚。本研究的目的旨在评估钙化性MS患者的临床症状、并发症及影响全因死亡率的因素。

本研究纳入分析了491名孤立性MS患者,其中200名患者为钙化性MS(平均年龄78 ± 11岁,男性占18%,32%患有房颤)。患者二尖瓣面积和跨瓣压差(TMG)分别为1.26±0.19cm~2和8.1±3.8mm Hg。120例(60%)患者在基线检查时出现症状;20例(10%)在2.8±3.0年的随访中出现症状。患者的1年生存率为72%且没有接受再介入治疗。Charlson共并发症指数>5(HR:1.53;95%CI:1.04~2.26;p<0.01)、TMG≥8mm Hg(HR:1.68;95%CI:1.12~2.51;p=0.012)、右室收缩压≥50mm Hg(HR:2.27;95%CI:1.50~3.43;p<0.01)与死亡率独立相关。另外,临床症状不会死亡风险相关。

研究结果显示,孤立性重度钙化性MS患者的并发症发生率较高,导致了较高的死亡率,有60%的患者出现临床症状,但与死亡风险不呈相关性。

原始出处:

Nahoko K et al.The Natural History of Severe Calcific Mitral Stenosis.JACC.2020 June.

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    2021-02-06 hbwxf
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    2020-10-17 venlin
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    2020-06-24 wwzzly

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