Oral Dis:光生物调控可有效治疗口腔扁平苔藓

2021-12-08 MedSci原创 MedSci原创

口腔扁平苔藓(OLP)是一种慢性粘膜炎症性疾病,以女性居多。OLP的病因不明,但有证据表明,这种疾病是一个由CD4+和CD8+T淋巴细胞以及各种炎症细胞因子协调的免疫介导过程,导致上皮细胞的凋亡。

口腔扁平苔藓(OLP)是一种慢性粘膜炎症性疾病,以女性居多。OLP的病因不明,但有证据表明,这种疾病是一个由CD4+和CD8+T淋巴细胞以及各种炎症细胞因子协调的免疫介导过程,导致上皮细胞的凋亡。光生物调节(PBM)是治疗OLP的一种选择,可有效减轻疼痛、解决炎症和促进组织修复。然而,PBM在OLP治疗中的疗效仍不确定。一些研究表明,与PBM相比,使用局部皮质激素的传统疗法能更好地控制OLP的疼痛和大小。近日,发表于Oral Dis的一项随机、双盲、对照的临床试验比较了PBM与丙酸氯倍他索0.05%的局部皮质激素治疗在OLP治疗中的疗效,特别是关注OLP的症状、功能能力、临床解决和复发情况。

研究共纳入了34名有症状的OLP患者,随机分配到两组:(a) 对照组(n = 17),连续30天每天三次外用丙酸氯倍他索,每周使用两次激光安慰剂以掩盖治疗;(b) 光生物调节组(n = 17),每周使用两次激光,共计8次,连续30天使用凝胶安慰剂以掩盖治疗。在治疗期间和治疗后30、60和90天,每周进行一次评估。对以下参数进行了评估:疼痛、临床评分、临床解决和复发率。

结果显示,治疗和随访期间,光生物调节和丙酸氯倍他索0.05%能够显著减少口腔扁平苔藓患者的疼痛并改善临床评分。对照组和光生物调控组都呈现出类似的临床效果和复发率。最重要的是,在治疗和随访期间,没有观察到治疗之间的差异。

综上所述,这些发现表明,每周两次的光生物调控在治疗口腔扁平苔藓方面与皮质激素疗法一样有效。此外,光生物调控是一种安全和非侵入性的疗法,且无不良反应。

原始出处:

Elza P Ferri,et al., Photobiomodulation is effective in oral lichen planus: A randomized, controlled, double-blind study. Oral Dis. 2021 Jul;27(5):1205-1216. doi: 10.1111/odi.13662.  

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    2021-12-26 小几洁
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