J Coll Physicians Surg Pak:缬沙坦单用或与硫辛酸合用对早期糖尿病肾病患者炎症细胞因子和肾功能的疗效观察

2020-06-16 MedSci原创 MedSci原创

本研究旨在比较缬沙坦单用或联合α-硫辛酸(ALA)对早期糖尿病肾病(DKD)患者的炎症细胞因子指标包括高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)

本研究旨在比较缬沙坦单用或联合α-硫辛酸(ALA)对早期糖尿病肾病(DKD)患者的炎症细胞因子指标包括高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)和肾功能指标包括尿白蛋白排泄率(UAER)、β2-微球蛋白(β2-MG)和胱抑素C(Cys C)的疗效。

 

将102例早期DKD患者随机分为A组和B组,每组51例。A组单独使用缬沙坦,B组则使用缬沙坦联合ALA进行治疗。研究显示,治疗14天后,B组与A组相比,hs-CRP、TNF-α、UAER、β2-MG和Cys C均显著降低(均P<0.001)。与单用缬沙坦相比,缬沙坦联合ALA可降低血清中炎性细胞因子的水平,改善肾功能。

 

原始出处:

 

Ziyuan Jiang , Zhen Tan, et al., Curative Effects of Valsartan Alone or Combined With Alpha-lipoic Acid on Inflammatory Cytokines and Renal Function in Early-stage Diabetic Kidney Disease. J Coll Physicians Surg Pak. 2019 Oct;29(10):1009-1011.

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    2021-02-26 waiwai3030
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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032537, encodeId=44b8103253e19, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Tue Jun 16 21:12:43 CST 2020, time=2020-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043175, encodeId=761d10431e598, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Jun 16 21:12:43 CST 2020, time=2020-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=602364, encodeId=0e87602364a0, content=α-硫辛酸抗氧化作用很强, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily@163, createdTime=Tue Jun 16 19:49:52 CST 2020, time=2020-06-16, status=1, ipAttribution=)]
    2020-09-02 yese
  5. 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  6. 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  7. 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  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032537, encodeId=44b8103253e19, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Tue Jun 16 21:12:43 CST 2020, time=2020-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043175, encodeId=761d10431e598, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Jun 16 21:12:43 CST 2020, time=2020-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=602364, encodeId=0e87602364a0, content=α-硫辛酸抗氧化作用很强, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily@163, createdTime=Tue Jun 16 19:49:52 CST 2020, time=2020-06-16, status=1, ipAttribution=)]
    2020-06-16 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032537, encodeId=44b8103253e19, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Tue Jun 16 21:12:43 CST 2020, time=2020-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043175, encodeId=761d10431e598, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Jun 16 21:12:43 CST 2020, time=2020-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=602364, encodeId=0e87602364a0, content=α-硫辛酸抗氧化作用很强, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily@163, createdTime=Tue Jun 16 19:49:52 CST 2020, time=2020-06-16, status=1, ipAttribution=)]
    2020-06-16 misszhang

    谢谢MedSci提供最新的资讯

    0

  10. 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channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily@163, createdTime=Tue Jun 16 19:49:52 CST 2020, time=2020-06-16, status=1, ipAttribution=)]
    2020-06-16 lifefamily@163

    α-硫辛酸抗氧化作用很强

    0

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