JNNP:线性法测量多发性硬化和临床孤立综合征的脑萎缩:一项30年随访研究

2021-04-13 MedSci原创 MedSci原创

多发性硬化症(MS)是一种中枢神经系统的慢性炎症、脱髓鞘和神经退行性疾病。大约85%的MS患者最初患有复发-缓解型(RR)MS,这与炎症性脱髓鞘病变的发生有关,从长期来看,大多数患者会发展为继发性进行

多发性硬化症(MS)是一种中枢神经系统的慢性炎症、脱髓鞘和神经退行性疾病。大约85%的MS患者最初患有复发-缓解型(RR)MS,这与炎症性脱髓鞘病变的发生有关,从长期来看,大多数患者会发展为继发性进行性(SP)MS。 神经退行性变被认为是残疾的主要原因 ,也是MRI在体内测量的脑萎缩的主要相关因素。 虽然脑萎缩发生在MS的早期,但与RRMS相比,SPMS患者的脑萎缩似乎更快,目前尚不清楚早期脑萎缩是否与长期临床结果显著相关,也不清楚是否可以作为早期治疗的靶点。

本课题组最近完成了一项为期30年的纵向、临床和MRI随访研究,研究对象是在临床孤立综合征(CIS)提示MS后不久招募的一个队列。在120名已知结局的患者中(最初招募的132名患者中),三分之一的患者仍被归类为CIS患者,三分之一的患者发展为SPMS或MS导致其死亡,其余患者有RRMS,其中约90%的患者由于MS而能够自由行走。 

本研究中探讨了局部脑萎缩与30年临床结果之间的关系。早期时间点的MRI扫描不能用当前的体积萎缩测量方法进行分析,因此,本文使用两种线性萎缩测量方法评估了30年来的脑萎缩率。

在1984年至1987年间前瞻性地招募了132名具有提示MS的CIS的患者,并在基线检查时、1年、5年、10年、14年、20年和30年进行了临床评估和MRI脑扫描。残疾状态量表(EDSS)评分可从基线检查(通过回顾性检查记录)、5年、10年、14年和20年获得。在30岁时,通过临床检查或电话获得EDS。在87名活着的参与者中有62名中,还获得了以下数据:25英尺步行时间(T25FW)、九孔柱测验(9HPT)、评估信息处理速度的配速听觉连续加法试验(PASAT)和国际简明听力测验多发性硬化症认知评估(BICAMS)分数, 其中包括简明视觉空间记忆测验(BVMTR)、符号数字模式测验(SDMT)和加利福尼亚言语学习测验。 

现有的容积MRI分析方法不能用于基线、1年、5年和10年的数据,因此采用线性测量。

Figure 1

30年萎缩变化

测量第三脑室宽度(TVW)是一项已建立的技术,与MS的长期残疾进展相关。 TVW是在基线、1年、5年、10年、14年和20年时,在轴向获得的T2加权MR扫描中,测量平行于心室长轴的直线中点处的第三脑室宽度,30岁时T2加权像。本文开发了第二个线性测量方法,髓质宽度(MEDW)是在垂直于颅尾侧脊髓方向的中矢状面图像上测量的延髓背腔直径。髓质测量的水平由脑桥下切迹的颅尾侧脑桥长度确定。

Figure 2

CIS后30年内残疾和萎缩的变化

30岁时,27名受试者仍被归类为临床孤立综合征,34名转为复发缓解型多发性硬化症,26名转为继发进行性多发性硬化症,16名死于多发性硬化症。基线检查时的平均年龄为31.7岁,平均病程为30.8年。前5年内延髓和第三脑室宽度的变化,考虑到白质病变的累积和同期残疾状态量表的扩大,预测了30年后的临床结果。使用logistic回归分析,前5年内1毫米的骨髓萎缩使继发进行性多发性硬化或多发性硬化相关死亡的风险增加了583%(或5.83,95%可信区间1.74至19.61,p<0.005)。

本文研究结果显示,临床孤立综合征5年内的脑局部萎缩预示着进行性多发性硬化或相关死亡,25年后会导致残疾。

Haider LChung KBirch G, et al Linear brain atrophy measures in multiple sclerosis and clinically isolated syndromes: a 30-year follow-up

 

 

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    2021-11-02 chendoc252
  3. [GetPortalCommentsPageByObjectIdResponse(id=1716563, encodeId=90541e165638c, content=<a href='/topic/show?id=afa5984e47a' target=_blank style='color:#2F92EE;'>#随访研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98474, encryptionId=afa5984e47a, topicName=随访研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9c1232248438, createdName=habb, createdTime=Wed Dec 29 08:10:50 CST 2021, time=2021-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695980, encodeId=cbc016959809a, content=<a href='/topic/show?id=03b98809697' target=_blank style='color:#2F92EE;'>#萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88096, encryptionId=03b98809697, topicName=萎缩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53fc29868494, createdName=chendoc252, createdTime=Tue Nov 02 23:10:50 CST 2021, time=2021-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1890239, encodeId=5525189023999, content=<a href='/topic/show?id=760c430895a' target=_blank style='color:#2F92EE;'>#多发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43089, encryptionId=760c430895a, topicName=多发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Thu Nov 18 04:10:50 CST 2021, time=2021-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401221, encodeId=b6ec140122171, content=<a href='/topic/show?id=3405850e3f4' target=_blank style='color:#2F92EE;'>#脑萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85073, encryptionId=3405850e3f4, topicName=脑萎缩)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/xdmCjlickSzn2cxg75bTZeYl2VYrTV6hibyMlic5XVFkibQbmFB7tK72afyxE4iclBhv7qd91qSk8Q6yicAcmErXRFxQ/132, createdBy=2c5d2304811, createdName=smartjoy, createdTime=Thu Apr 15 09:10:50 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1432041, encodeId=769f143204171, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Apr 15 09:10:50 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956680, encodeId=e3b4956680ee, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue Apr 13 19:04:11 CST 2021, time=2021-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956651, encodeId=bbe7956651f0, content=三人行,必有我师。 <a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a> 欢迎您的加入,添加【梅斯医学科研助手WeChat:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=梅干儿, createdTime=Tue Apr 13 18:14:13 CST 2021, time=2021-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956650, encodeId=e012956650f5, content=👇👇👇【社群入口】移动端用户可点击图片长按保存,到WeChat打开扫描入群!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=[AttachmentDto(url=https://img.medsci.cn/comment/20210413/dd3e37017361489e8d99b935f63f304b.png, type=image, width=464, height=464)], authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=梅干儿, createdTime=Tue Apr 13 18:13:57 CST 2021, time=2021-04-13, status=1, ipAttribution=)]
    2021-11-18 jml2009
  4. [GetPortalCommentsPageByObjectIdResponse(id=1716563, encodeId=90541e165638c, content=<a href='/topic/show?id=afa5984e47a' target=_blank style='color:#2F92EE;'>#随访研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98474, encryptionId=afa5984e47a, topicName=随访研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9c1232248438, createdName=habb, createdTime=Wed Dec 29 08:10:50 CST 2021, time=2021-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695980, encodeId=cbc016959809a, content=<a href='/topic/show?id=03b98809697' target=_blank style='color:#2F92EE;'>#萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88096, encryptionId=03b98809697, topicName=萎缩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53fc29868494, createdName=chendoc252, createdTime=Tue Nov 02 23:10:50 CST 2021, time=2021-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1890239, encodeId=5525189023999, content=<a href='/topic/show?id=760c430895a' target=_blank style='color:#2F92EE;'>#多发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43089, encryptionId=760c430895a, topicName=多发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Thu Nov 18 04:10:50 CST 2021, time=2021-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401221, encodeId=b6ec140122171, content=<a href='/topic/show?id=3405850e3f4' target=_blank style='color:#2F92EE;'>#脑萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85073, encryptionId=3405850e3f4, topicName=脑萎缩)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/xdmCjlickSzn2cxg75bTZeYl2VYrTV6hibyMlic5XVFkibQbmFB7tK72afyxE4iclBhv7qd91qSk8Q6yicAcmErXRFxQ/132, createdBy=2c5d2304811, createdName=smartjoy, createdTime=Thu Apr 15 09:10:50 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1432041, encodeId=769f143204171, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Apr 15 09:10:50 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956680, encodeId=e3b4956680ee, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue Apr 13 19:04:11 CST 2021, time=2021-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956651, encodeId=bbe7956651f0, content=三人行,必有我师。 <a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a> 欢迎您的加入,添加【梅斯医学科研助手WeChat:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=梅干儿, createdTime=Tue Apr 13 18:14:13 CST 2021, time=2021-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956650, encodeId=e012956650f5, content=👇👇👇【社群入口】移动端用户可点击图片长按保存,到WeChat打开扫描入群!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=[AttachmentDto(url=https://img.medsci.cn/comment/20210413/dd3e37017361489e8d99b935f63f304b.png, type=image, width=464, height=464)], authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=梅干儿, createdTime=Tue Apr 13 18:13:57 CST 2021, time=2021-04-13, status=1, ipAttribution=)]
  5. 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【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=梅干儿, createdTime=Tue Apr 13 18:14:13 CST 2021, time=2021-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956650, encodeId=e012956650f5, content=👇👇👇【社群入口】移动端用户可点击图片长按保存,到WeChat打开扫描入群!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=[AttachmentDto(url=https://img.medsci.cn/comment/20210413/dd3e37017361489e8d99b935f63f304b.png, type=image, width=464, height=464)], authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=梅干儿, createdTime=Tue Apr 13 18:13:57 CST 2021, time=2021-04-13, status=1, ipAttribution=)]
  6. 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【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=梅干儿, createdTime=Tue Apr 13 18:14:13 CST 2021, time=2021-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956650, encodeId=e012956650f5, content=👇👇👇【社群入口】移动端用户可点击图片长按保存,到WeChat打开扫描入群!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=[AttachmentDto(url=https://img.medsci.cn/comment/20210413/dd3e37017361489e8d99b935f63f304b.png, type=image, width=464, height=464)], authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=梅干儿, createdTime=Tue Apr 13 18:13:57 CST 2021, time=2021-04-13, status=1, ipAttribution=)]
    2021-04-13 jyzxjiangqin

    好文章!

    0

  7. 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【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=梅干儿, createdTime=Tue Apr 13 18:14:13 CST 2021, time=2021-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956650, encodeId=e012956650f5, content=👇👇👇【社群入口】移动端用户可点击图片长按保存,到WeChat打开扫描入群!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=[AttachmentDto(url=https://img.medsci.cn/comment/20210413/dd3e37017361489e8d99b935f63f304b.png, type=image, width=464, height=464)], authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=梅干儿, createdTime=Tue Apr 13 18:13:57 CST 2021, time=2021-04-13, status=1, ipAttribution=)]
    2021-04-13 梅干儿

    三人行,必有我师。 #梅斯医学科研互助群# 欢迎您的加入,添加【梅斯医学科研助手WeChat:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!

    0

  8. 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【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=梅干儿, createdTime=Tue Apr 13 18:14:13 CST 2021, time=2021-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956650, encodeId=e012956650f5, content=👇👇👇【社群入口】移动端用户可点击图片长按保存,到WeChat打开扫描入群!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=[AttachmentDto(url=https://img.medsci.cn/comment/20210413/dd3e37017361489e8d99b935f63f304b.png, type=image, width=464, height=464)], authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=梅干儿, createdTime=Tue Apr 13 18:13:57 CST 2021, time=2021-04-13, status=1, ipAttribution=)]

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Neurology:多发性硬化:不同临床分型,对应的灰质受累类型各有不同

Neurology:多发性硬化:不同临床分型,对应的灰质受累类型各有不同

BRAIN: 7T MRI检测MS铁环病变的长期演变

多发性硬化症病变周围的铁环显示了不同的体积动力学,病变内和周围的神经变性增加。随着时间的推移,铁环会缓慢扩张,失去边缘,并导致轴突损伤。

Cell Death Differ:NDP52突变能够促进线粒体自噬并抑制多发性硬化症中的炎症反应

多发性硬化症(MS)是一种自身免疫性疾病,其能够引起中枢神经系统的慢性炎症反应,导致脱髓鞘和轴突的损伤,最终导致运动、感觉和认知的丧失。