TAG: 英夫利昔单抗治疗对回肠结肠克罗恩病患者不同肠段黏膜愈合的作用差异

2021-01-17 MedSci原创 MedSci原创

克罗恩病(CD)是一种慢性复发性炎症性肠病(IBD),经常导致患者出现狭窄,脓肿或瘘管等疾病并发症。

 

      克罗恩病(CD)是一种慢性复发性炎症性肠病(IBD),经常导致患者出现狭窄,脓肿或瘘管等疾病并发症。治疗CD的药物包括皮质类固醇,硫唑嘌呤(AZA),甲氨蝶呤和生物制剂。随着第一种生物制剂抗肿瘤坏死因子(anti-TNF)单克隆抗体inixixab(IFX)的问世,“靶向治疗”策略已成为近年来用于IBD的主要治疗策略。治疗的目标已从控制临床症状转变为实现具有较好长期效果的粘膜愈合(MH)MH通常是指没有通过内窥镜检查评估的溃疡和糜烂。然而,目前尚无关于IBD中MH的有效定义。MH的标准和客观定义是通过内窥镜活动指数(包括克罗恩病的简单内窥镜评分(SES-CD)和克罗恩病内镜严重程度的内镜指数(CDEIS))进行的,它们在临床试验和临床实践中得到了广泛使用。

 

      VERSIFY研究表明,使用维多珠单抗治疗时,横结肠和右结肠的MH率高于左结肠和回肠的MH。作为第一种生物制剂,IFX在世界范围内已用于治疗CD超过20年。然而,关于MH在不同回结肠段(即直肠,乙状结肠/左结肠,横结肠,右结肠和回肠末端)的疗效尚不清楚。因此,本项研究旨在探究接受IFX治疗的CD患者不同回肠结肠段的内镜MH差异。

 

 

      研究人员收集了在2012年1月至2018年12月间存在活动性回结肠结肠CD患者的临床资料。所有患者均接受了IFX治疗至少30周的治疗。在基线,14/22周和30/38周时,通过CD的简单内镜评分(SES-CD)评估五个回肠结肠段的MH情况。校正混杂因素后,通过混合效应模型分析SES-CD值。

 

 

 

      本项研究最后总共纳入101名合格患者。基线内窥镜检查的严重程度在各段中相似。在30/38周时,横结肠结肠SES-CD溃疡大小和溃疡表面亚评分的最大变化均为-94.29%和-94.32%(p <0.0001)。所有患者的狭窄主要表现在右结肠(12 / 29,41.38%)。在30/38周时,右结肠SES-CD狭窄亚评分的变化为-6.25%,而在14/22周时为-71.88%(p = 0.0030)。在30/38周时,横结肠结肠的最高MH(CMH)发生率最高,为81.2%,而回肠末端的CMH最低,发生率为45.6%。此外,直肠的改善程度与疾病进展呈负相关(p  = 0.011)。

 

 

      因此,作者最后说道:在IFX治疗期间,CD中的不同肠段节段表现出不同程度的内镜MH。横结肠显示最高的CMH率,右狭窄的结肠表现出最差的改善率。因此,不同病变部位的CD患者应该选用不同的生物制剂进行治疗。

 

 

 

原始出处:

Yaling Wu. Et al. Efficacy of infliximab treatment on the mucosal healing of different intestinal segments in patients with ileocolonic Crohn’s diseass. Therapeutic Advances in Gastroenterology.2021.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1994923, encodeId=13c4199492359, content=<a href='/topic/show?id=bd3f10325926' target=_blank style='color:#2F92EE;'>#黏膜愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103259, encryptionId=bd3f10325926, topicName=黏膜愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Thu Apr 29 18:14:22 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000493, encodeId=0a70100049333, content=对部位还是有区别的, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69265107240, createdName=14608a91m05暂无昵称, createdTime=Sun Jul 18 00:03:08 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976424, encodeId=e2089e6424eb, content=可不可以不同生物制剂同时使用, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/e9408422a23545ef9738dd674abfc4ff/c719925083844b82986bc39d43051172.jpg, createdBy=8eb14795142, createdName=与狼共舞, createdTime=Thu Jun 24 07:45:27 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511372, encodeId=82e315113e20a, content=<a href='/topic/show?id=d47d40542cc' target=_blank style='color:#2F92EE;'>#回肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40542, encryptionId=d47d40542cc, topicName=回肠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b1110335485, createdName=Tamikia, createdTime=Tue Jan 19 02:14:22 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520078, encodeId=0cc315200e83d, content=<a href='/topic/show?id=6ab11032506f' target=_blank style='color:#2F92EE;'>#黏膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103250, encryptionId=6ab11032506f, topicName=黏膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=057f11309297, createdName=snowpeakxu, createdTime=Tue Jan 19 02:14:22 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917428, encodeId=64da91e42810, content=<a href='/topic/show?id=8eeb8e122c6' target=_blank style='color:#2F92EE;'>#英夫利昔单抗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87122, encryptionId=8eeb8e122c6, topicName=英夫利昔单抗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sun Jan 17 12:33:10 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917424, encodeId=e06391e424b8, content=<a href='/topic/show?id=fde528896bd' target=_blank style='color:#2F92EE;'>#克罗恩病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28896, encryptionId=fde528896bd, topicName=克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sun Jan 17 12:31:49 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917414, encodeId=435d91e414fc, content=不同病变部位的CD患者应该选用不同的生物制剂进行治疗。<a href='/topic/show?id=fde528896bd' target=_blank style='color:#2F92EE;'>#克罗恩病#</a>制定个性化方案, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28896, encryptionId=fde528896bd, topicName=克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210315/480e12f811f44bc39b347d2521d56e86/67d0e6d503124ea685205b567af3dffd.jpg, createdBy=f9435296193, createdName=Baodongxu, createdTime=Sun Jan 17 11:45:52 CST 2021, time=2021-01-17, status=1, ipAttribution=)]
    2021-07-18 14608a91m05暂无昵称

    对部位还是有区别的

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1994923, encodeId=13c4199492359, content=<a href='/topic/show?id=bd3f10325926' target=_blank style='color:#2F92EE;'>#黏膜愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103259, encryptionId=bd3f10325926, topicName=黏膜愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Thu Apr 29 18:14:22 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000493, encodeId=0a70100049333, content=对部位还是有区别的, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69265107240, createdName=14608a91m05暂无昵称, createdTime=Sun Jul 18 00:03:08 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976424, encodeId=e2089e6424eb, content=可不可以不同生物制剂同时使用, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/e9408422a23545ef9738dd674abfc4ff/c719925083844b82986bc39d43051172.jpg, createdBy=8eb14795142, createdName=与狼共舞, createdTime=Thu Jun 24 07:45:27 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511372, encodeId=82e315113e20a, content=<a href='/topic/show?id=d47d40542cc' target=_blank style='color:#2F92EE;'>#回肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40542, encryptionId=d47d40542cc, topicName=回肠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b1110335485, createdName=Tamikia, createdTime=Tue Jan 19 02:14:22 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520078, encodeId=0cc315200e83d, content=<a href='/topic/show?id=6ab11032506f' target=_blank style='color:#2F92EE;'>#黏膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103250, encryptionId=6ab11032506f, topicName=黏膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=057f11309297, createdName=snowpeakxu, createdTime=Tue Jan 19 02:14:22 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917428, encodeId=64da91e42810, content=<a href='/topic/show?id=8eeb8e122c6' target=_blank style='color:#2F92EE;'>#英夫利昔单抗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87122, encryptionId=8eeb8e122c6, topicName=英夫利昔单抗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sun Jan 17 12:33:10 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917424, encodeId=e06391e424b8, content=<a href='/topic/show?id=fde528896bd' target=_blank style='color:#2F92EE;'>#克罗恩病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28896, encryptionId=fde528896bd, topicName=克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sun Jan 17 12:31:49 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917414, encodeId=435d91e414fc, content=不同病变部位的CD患者应该选用不同的生物制剂进行治疗。<a href='/topic/show?id=fde528896bd' target=_blank style='color:#2F92EE;'>#克罗恩病#</a>制定个性化方案, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28896, encryptionId=fde528896bd, topicName=克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210315/480e12f811f44bc39b347d2521d56e86/67d0e6d503124ea685205b567af3dffd.jpg, createdBy=f9435296193, createdName=Baodongxu, createdTime=Sun Jan 17 11:45:52 CST 2021, time=2021-01-17, status=1, ipAttribution=)]
    2021-06-24 与狼共舞

    可不可以不同生物制剂同时使用

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1994923, encodeId=13c4199492359, content=<a href='/topic/show?id=bd3f10325926' target=_blank style='color:#2F92EE;'>#黏膜愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103259, encryptionId=bd3f10325926, topicName=黏膜愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Thu Apr 29 18:14:22 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000493, encodeId=0a70100049333, content=对部位还是有区别的, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69265107240, createdName=14608a91m05暂无昵称, createdTime=Sun Jul 18 00:03:08 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976424, encodeId=e2089e6424eb, content=可不可以不同生物制剂同时使用, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/e9408422a23545ef9738dd674abfc4ff/c719925083844b82986bc39d43051172.jpg, createdBy=8eb14795142, createdName=与狼共舞, createdTime=Thu Jun 24 07:45:27 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511372, encodeId=82e315113e20a, content=<a href='/topic/show?id=d47d40542cc' target=_blank style='color:#2F92EE;'>#回肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40542, encryptionId=d47d40542cc, topicName=回肠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b1110335485, createdName=Tamikia, createdTime=Tue Jan 19 02:14:22 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520078, encodeId=0cc315200e83d, content=<a href='/topic/show?id=6ab11032506f' target=_blank style='color:#2F92EE;'>#黏膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103250, encryptionId=6ab11032506f, topicName=黏膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=057f11309297, createdName=snowpeakxu, createdTime=Tue Jan 19 02:14:22 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917428, encodeId=64da91e42810, content=<a href='/topic/show?id=8eeb8e122c6' target=_blank style='color:#2F92EE;'>#英夫利昔单抗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87122, encryptionId=8eeb8e122c6, topicName=英夫利昔单抗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sun Jan 17 12:33:10 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917424, encodeId=e06391e424b8, content=<a href='/topic/show?id=fde528896bd' target=_blank style='color:#2F92EE;'>#克罗恩病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28896, encryptionId=fde528896bd, topicName=克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sun Jan 17 12:31:49 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917414, encodeId=435d91e414fc, content=不同病变部位的CD患者应该选用不同的生物制剂进行治疗。<a href='/topic/show?id=fde528896bd' target=_blank style='color:#2F92EE;'>#克罗恩病#</a>制定个性化方案, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28896, encryptionId=fde528896bd, topicName=克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210315/480e12f811f44bc39b347d2521d56e86/67d0e6d503124ea685205b567af3dffd.jpg, createdBy=f9435296193, createdName=Baodongxu, createdTime=Sun Jan 17 11:45:52 CST 2021, time=2021-01-17, status=1, ipAttribution=)]
    2021-01-19 Tamikia
  5. [GetPortalCommentsPageByObjectIdResponse(id=1994923, encodeId=13c4199492359, content=<a href='/topic/show?id=bd3f10325926' target=_blank style='color:#2F92EE;'>#黏膜愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103259, encryptionId=bd3f10325926, topicName=黏膜愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Thu Apr 29 18:14:22 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000493, encodeId=0a70100049333, content=对部位还是有区别的, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69265107240, createdName=14608a91m05暂无昵称, createdTime=Sun Jul 18 00:03:08 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976424, encodeId=e2089e6424eb, content=可不可以不同生物制剂同时使用, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/e9408422a23545ef9738dd674abfc4ff/c719925083844b82986bc39d43051172.jpg, createdBy=8eb14795142, createdName=与狼共舞, createdTime=Thu Jun 24 07:45:27 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511372, encodeId=82e315113e20a, content=<a href='/topic/show?id=d47d40542cc' target=_blank style='color:#2F92EE;'>#回肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40542, encryptionId=d47d40542cc, topicName=回肠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b1110335485, createdName=Tamikia, createdTime=Tue Jan 19 02:14:22 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520078, encodeId=0cc315200e83d, content=<a href='/topic/show?id=6ab11032506f' target=_blank style='color:#2F92EE;'>#黏膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103250, encryptionId=6ab11032506f, topicName=黏膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=057f11309297, createdName=snowpeakxu, createdTime=Tue Jan 19 02:14:22 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917428, encodeId=64da91e42810, content=<a href='/topic/show?id=8eeb8e122c6' target=_blank style='color:#2F92EE;'>#英夫利昔单抗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87122, encryptionId=8eeb8e122c6, topicName=英夫利昔单抗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sun Jan 17 12:33:10 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917424, encodeId=e06391e424b8, content=<a href='/topic/show?id=fde528896bd' target=_blank style='color:#2F92EE;'>#克罗恩病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28896, encryptionId=fde528896bd, topicName=克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sun Jan 17 12:31:49 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917414, encodeId=435d91e414fc, content=不同病变部位的CD患者应该选用不同的生物制剂进行治疗。<a href='/topic/show?id=fde528896bd' target=_blank style='color:#2F92EE;'>#克罗恩病#</a>制定个性化方案, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28896, encryptionId=fde528896bd, topicName=克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210315/480e12f811f44bc39b347d2521d56e86/67d0e6d503124ea685205b567af3dffd.jpg, createdBy=f9435296193, createdName=Baodongxu, createdTime=Sun Jan 17 11:45:52 CST 2021, time=2021-01-17, status=1, ipAttribution=)]
    2021-01-19 snowpeakxu
  6. [GetPortalCommentsPageByObjectIdResponse(id=1994923, encodeId=13c4199492359, content=<a href='/topic/show?id=bd3f10325926' target=_blank style='color:#2F92EE;'>#黏膜愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103259, encryptionId=bd3f10325926, topicName=黏膜愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Thu Apr 29 18:14:22 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000493, encodeId=0a70100049333, content=对部位还是有区别的, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69265107240, createdName=14608a91m05暂无昵称, createdTime=Sun Jul 18 00:03:08 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976424, encodeId=e2089e6424eb, content=可不可以不同生物制剂同时使用, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/e9408422a23545ef9738dd674abfc4ff/c719925083844b82986bc39d43051172.jpg, createdBy=8eb14795142, createdName=与狼共舞, createdTime=Thu Jun 24 07:45:27 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511372, encodeId=82e315113e20a, content=<a href='/topic/show?id=d47d40542cc' target=_blank style='color:#2F92EE;'>#回肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40542, encryptionId=d47d40542cc, topicName=回肠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b1110335485, createdName=Tamikia, createdTime=Tue Jan 19 02:14:22 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520078, encodeId=0cc315200e83d, content=<a href='/topic/show?id=6ab11032506f' target=_blank style='color:#2F92EE;'>#黏膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103250, encryptionId=6ab11032506f, topicName=黏膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=057f11309297, createdName=snowpeakxu, createdTime=Tue Jan 19 02:14:22 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917428, encodeId=64da91e42810, content=<a href='/topic/show?id=8eeb8e122c6' target=_blank style='color:#2F92EE;'>#英夫利昔单抗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87122, encryptionId=8eeb8e122c6, topicName=英夫利昔单抗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sun Jan 17 12:33:10 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917424, encodeId=e06391e424b8, content=<a href='/topic/show?id=fde528896bd' target=_blank style='color:#2F92EE;'>#克罗恩病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28896, encryptionId=fde528896bd, topicName=克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sun Jan 17 12:31:49 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917414, encodeId=435d91e414fc, content=不同病变部位的CD患者应该选用不同的生物制剂进行治疗。<a href='/topic/show?id=fde528896bd' target=_blank style='color:#2F92EE;'>#克罗恩病#</a>制定个性化方案, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28896, encryptionId=fde528896bd, topicName=克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210315/480e12f811f44bc39b347d2521d56e86/67d0e6d503124ea685205b567af3dffd.jpg, createdBy=f9435296193, createdName=Baodongxu, createdTime=Sun Jan 17 11:45:52 CST 2021, time=2021-01-17, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1994923, encodeId=13c4199492359, content=<a href='/topic/show?id=bd3f10325926' target=_blank style='color:#2F92EE;'>#黏膜愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103259, encryptionId=bd3f10325926, topicName=黏膜愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Thu Apr 29 18:14:22 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000493, encodeId=0a70100049333, content=对部位还是有区别的, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69265107240, createdName=14608a91m05暂无昵称, createdTime=Sun Jul 18 00:03:08 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976424, encodeId=e2089e6424eb, content=可不可以不同生物制剂同时使用, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/e9408422a23545ef9738dd674abfc4ff/c719925083844b82986bc39d43051172.jpg, createdBy=8eb14795142, createdName=与狼共舞, createdTime=Thu Jun 24 07:45:27 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511372, encodeId=82e315113e20a, content=<a href='/topic/show?id=d47d40542cc' target=_blank style='color:#2F92EE;'>#回肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40542, encryptionId=d47d40542cc, topicName=回肠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b1110335485, createdName=Tamikia, createdTime=Tue Jan 19 02:14:22 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520078, encodeId=0cc315200e83d, content=<a href='/topic/show?id=6ab11032506f' target=_blank style='color:#2F92EE;'>#黏膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103250, encryptionId=6ab11032506f, topicName=黏膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=057f11309297, createdName=snowpeakxu, createdTime=Tue Jan 19 02:14:22 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917428, encodeId=64da91e42810, content=<a href='/topic/show?id=8eeb8e122c6' target=_blank style='color:#2F92EE;'>#英夫利昔单抗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87122, encryptionId=8eeb8e122c6, topicName=英夫利昔单抗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sun Jan 17 12:33:10 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917424, encodeId=e06391e424b8, content=<a href='/topic/show?id=fde528896bd' target=_blank style='color:#2F92EE;'>#克罗恩病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28896, encryptionId=fde528896bd, topicName=克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sun Jan 17 12:31:49 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917414, encodeId=435d91e414fc, content=不同病变部位的CD患者应该选用不同的生物制剂进行治疗。<a href='/topic/show?id=fde528896bd' target=_blank style='color:#2F92EE;'>#克罗恩病#</a>制定个性化方案, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28896, encryptionId=fde528896bd, topicName=克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210315/480e12f811f44bc39b347d2521d56e86/67d0e6d503124ea685205b567af3dffd.jpg, createdBy=f9435296193, createdName=Baodongxu, createdTime=Sun Jan 17 11:45:52 CST 2021, time=2021-01-17, status=1, ipAttribution=)]
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    2021-01-17 Baodongxu

    不同病变部位的CD患者应该选用不同的生物制剂进行治疗。#克罗恩病#制定个性化方案

    0

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