Lancet Neurology:基于影像学的风险评分预测缺血性卒中或短暂性缺血性发作后抗血栓治疗患者颅内出血和缺血性卒中的发展

2021-04-26 MedSci原创 MedSci原创

抗血栓治疗是缺血性卒中或短暂性脑缺血发作后二级预防的关键组成部分。在没有房颤的患者中,抗血小板治疗将总体中风风险降低了四分之一,而房颤患者口服抗凝治疗将这一风险降低了三分之二。

抗血栓治疗是缺血性卒中或短暂性脑缺血发作后二级预防的关键组成部分。在没有房颤的患者中,抗血小板治疗将总体中风风险降低了四分之一,而房颤患者口服抗凝治疗将这一风险降低了三分之二。尽管抗血栓治疗增加了颅内出血的风险(抗血小板增加了约四分之一,直接口服抗凝剂增加了一半,维生素K拮抗剂增加了两倍),但颅内出血的绝对发生率却大大降低,这意味着大多数患者被推荐使用抗血栓治疗。 对于在缺血性中风或短暂性缺血性发作后接受抗血栓治疗的患者来说,平衡复发性缺血性中风和颅内出血的风险非常重要。然而,现有的预测模型性能不足,尤其是在评估颅内出血的风险。本文旨在开发新的风险评分,包括临床变量和脑微出血,后者是颅内出血和缺血性中风风险的MRI生物标志物。 本研究对来自微出血国际合作网络(MICON)的个体患者数据进行了汇总分析,其中包括来自18个国家的38项基于医院的前瞻性队列研究。所有研究都招募了既往有缺血性中风或短暂性缺血性发作的患者,获得了量化脑微出血的基线MRI,并对缺血性中风和颅内出血患者进行了随访。其中未服用抗血栓药物的参与者被排除在外。 图1:有症状的颅内出血的Kaplan-Meier图和风险表&n

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    2021-10-14 yinhl1978
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  5. 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href='/topic/show?id=ee4955e5730' target=_blank style='color:#2F92EE;'>#抗血栓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55757, encryptionId=ee4955e5730, topicName=抗血栓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a26516008049, createdName=gwc388, createdTime=Wed Apr 28 12:55:01 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026832, encodeId=81781026832f8, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Tue Apr 27 00:55:01 CST 2021, time=2021-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034291, encodeId=93ca103429191, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Tue Apr 27 00:55:01 CST 2021, time=2021-04-27, status=1, ipAttribution=)]
    2021-09-19 howi
  6. 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  7. 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content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Tue Apr 27 00:55:01 CST 2021, time=2021-04-27, status=1, ipAttribution=)]
  8. 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href='/topic/show?id=ee4955e5730' target=_blank style='color:#2F92EE;'>#抗血栓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55757, encryptionId=ee4955e5730, topicName=抗血栓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a26516008049, createdName=gwc388, createdTime=Wed Apr 28 12:55:01 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026832, encodeId=81781026832f8, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Tue Apr 27 00:55:01 CST 2021, time=2021-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034291, encodeId=93ca103429191, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Tue Apr 27 00:55:01 CST 2021, time=2021-04-27, status=1, ipAttribution=)]
    2021-04-28 gwc388
  9. 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content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Tue Apr 27 00:55:01 CST 2021, time=2021-04-27, status=1, ipAttribution=)]
    2021-04-27 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  10. 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href='/topic/show?id=ee4955e5730' target=_blank style='color:#2F92EE;'>#抗血栓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55757, encryptionId=ee4955e5730, topicName=抗血栓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a26516008049, createdName=gwc388, createdTime=Wed Apr 28 12:55:01 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026832, encodeId=81781026832f8, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Tue Apr 27 00:55:01 CST 2021, time=2021-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034291, encodeId=93ca103429191, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Tue Apr 27 00:55:01 CST 2021, time=2021-04-27, status=1, ipAttribution=)]
    2021-04-27 goodbing

    顶刊就是不一样,质量很高,内容精彩!学到很多

    0

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