Diabetes Care:葡萄糖胺、炎症和遗传易感性与2型糖尿病发病率

2020-01-28 xing.T MedSci原创

由此可见,该研究的结果表明,使用葡萄糖胺可降低患T2D的风险。

葡萄糖胺广泛用于骨关节炎和关节痛的治疗。越来越多的证据表明,葡萄糖胺与葡萄糖代谢、炎症和心脏代谢风险之间存在潜在联系。近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员前瞻性地分析了习惯性使用葡萄糖胺与2型糖尿病(T2D)风险之间的关联,并评估了遗传易感性和炎症状态是否可能会改变这一关联。

该研究分析了英国生物库中的404508名参与者,他们在基线时没有糖尿病、癌症或心血管疾病,并完成了葡萄糖胺补充剂使用的调查表。研究人员使用Cox比例风险模型评估使用葡萄糖胺与T2D风险之间的关联。

在平均8.1年的随访期间,共记录到了7228例T2D患者。在调整了年龄、性别、BMI、民族、中心、汤森剥夺指数、生活方式因素、疾病史和其他补充剂后,使用葡萄糖胺与T2D风险显著降低相关(风险比为0.83,95%CI为0.78–0.89)。与炎症标记水平较低的参与者相比,在血液中基线C反应蛋白水平较高的参与者中这种负相关更为明显(相互作用P=0.02)。T2D的遗传风险评分并未改变这种关联(相互作用P=0.99)。

由此可见,该研究的结果表明,使用葡萄糖胺可降低患T2D的风险。

原始出处:


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    2020-01-28 misszhang

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