Frontiers in Neuroscience:可穿戴设备帮助AD和PD患者缓解病情

2020-12-24 MedSci原创 MedSci原创

阿尔茨海默病(AD)和帕金森病(PD)都是原发性的中枢神经系统退化疾病,发病原因尚不明确。从临床症状来看,多起病隐匿而缓慢,记忆和认知功能不断恶化,且不可逆。诸多研究显示,

阿尔茨海默病(AD)和帕金森病(PD)都是原发性的中枢神经系统退化疾病,发病原因尚不明确。从临床症状来看,多起病隐匿而缓慢,记忆和认知功能不断恶化,且不可逆。诸多研究显示,AD和PD最早出现的症状是嗅觉障碍,这也就意味着嗅觉障碍可能比认知障碍更能作为 AD和PD 的预警,而通过嗅觉测试可能更早预知是否得了这些可怕的神经退行性疾病。

近日,奥塔哥大学(University of Otago)研究小组试图开发非侵入式的可穿戴设备,通过刺激嗅觉-神经系统,在短期内缓解症状,进而阻止或逆转病程。

研究人员借助电场建模对多电极配置,通过可穿戴Google眼镜原型,在皮肤上产生细小的电子脉冲,以刺激嗅觉神经系统。该模型已在脑部手术过程中通过直接人脑记录进行了验证,结果显示,原型设备有效地将定向刺激到大脑的嗅觉-神经区域,让内嗅皮层更活跃。

穿戴刺激器和电刺激脑成像图

研究团队正在与Soterix Medical公司进行合作,将在临床试验中测试其可穿戴刺激器。研究人员表示,希望通过这种治疗方式以缓解症状或抑制AD和PD的发展。目前,越来越多的研究显示,AD和PD的最早期症状包括嗅觉受损,希望在理解了其机理后,进而提高 AD和PD的诊断率。

原始出处

Yusuf Ozgur Cakmak et al. Optimized Electrode Placements for Non-invasive Electrical Stimulation of the Olfactory Bulb and Olfactory Mucosa, Frontiers in Neuroscience (2020). 

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    2021-10-08 anminleiryan
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createdName=apoenzyme, createdTime=Sun Jul 11 00:41:54 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878358, encodeId=7c2318e8358c6, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Fri Oct 08 01:41:54 CST 2021, time=2021-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1700695, encodeId=8f501e00695b9, content=<a href='/topic/show?id=82bc38512a4' target=_blank style='color:#2F92EE;'>#可穿戴设备#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38512, 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channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Dec 26 13:41:54 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910925, encodeId=9c139109257e, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Fri Dec 25 17:16:32 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910826, encodeId=0fbc910826bd, content=可穿戴设备会是一个热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/H3QXYibjbzM9C5GELMGhjqMatvmOsXy5gzoqIT6XJqYYCg7BqyfaLVW7gmk0bjAUJygFZUxt3XakaHUP7VIGDww/132, createdBy=a1285314326, createdName=taken110, createdTime=Fri Dec 25 10:37:24 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910823, encodeId=34949108237d, content=可穿戴设备帮助AD和PD患者缓解病情,这个真的很好!非侵入式而且还不用吃药。, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Dec 25 10:21:10 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910819, encodeId=ec549108199f, content=good news and tool for AD, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Fri Dec 25 10:04:48 CST 2020, time=2020-12-25, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1765128, encodeId=4f7a1e6512856, content=<a href='/topic/show?id=df00e086653' target=_blank style='color:#2F92EE;'>#病情#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70866, encryptionId=df00e086653, topicName=病情)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Oct 06 02:41:54 CST 2021, time=2021-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953950, encodeId=b6ea19539502a, content=<a href='/topic/show?id=88ece544685' target=_blank style='color:#2F92EE;'>#穿戴设备#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75446, encryptionId=88ece544685, topicName=穿戴设备)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, 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channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Dec 26 13:41:54 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910925, encodeId=9c139109257e, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Fri Dec 25 17:16:32 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910826, encodeId=0fbc910826bd, content=可穿戴设备会是一个热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/H3QXYibjbzM9C5GELMGhjqMatvmOsXy5gzoqIT6XJqYYCg7BqyfaLVW7gmk0bjAUJygFZUxt3XakaHUP7VIGDww/132, createdBy=a1285314326, createdName=taken110, createdTime=Fri Dec 25 10:37:24 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910823, encodeId=34949108237d, content=可穿戴设备帮助AD和PD患者缓解病情,这个真的很好!非侵入式而且还不用吃药。, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Dec 25 10:21:10 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910819, encodeId=ec549108199f, content=good news and tool for AD, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Fri Dec 25 10:04:48 CST 2020, time=2020-12-25, status=1, ipAttribution=)]
    2020-12-26 lsndxfj
  6. [GetPortalCommentsPageByObjectIdResponse(id=1765128, encodeId=4f7a1e6512856, content=<a href='/topic/show?id=df00e086653' target=_blank style='color:#2F92EE;'>#病情#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70866, encryptionId=df00e086653, topicName=病情)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Oct 06 02:41:54 CST 2021, time=2021-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953950, encodeId=b6ea19539502a, content=<a href='/topic/show?id=88ece544685' target=_blank style='color:#2F92EE;'>#穿戴设备#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75446, encryptionId=88ece544685, topicName=穿戴设备)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, 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encodeId=ec549108199f, content=good news and tool for AD, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Fri Dec 25 10:04:48 CST 2020, time=2020-12-25, status=1, ipAttribution=)]
    2020-12-26 爆笑小医
  7. 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encryptionId=82bc38512a4, topicName=可穿戴设备)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=db8830213477, createdName=shalley76, createdTime=Sun Mar 07 08:41:54 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364679, encodeId=370d13646e936, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Sat Dec 26 13:41:54 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376224, encodeId=b53a13e6224f6, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Dec 26 13:41:54 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910925, encodeId=9c139109257e, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Fri Dec 25 17:16:32 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910826, encodeId=0fbc910826bd, content=可穿戴设备会是一个热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/H3QXYibjbzM9C5GELMGhjqMatvmOsXy5gzoqIT6XJqYYCg7BqyfaLVW7gmk0bjAUJygFZUxt3XakaHUP7VIGDww/132, createdBy=a1285314326, createdName=taken110, createdTime=Fri Dec 25 10:37:24 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910823, encodeId=34949108237d, content=可穿戴设备帮助AD和PD患者缓解病情,这个真的很好!非侵入式而且还不用吃药。, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Dec 25 10:21:10 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910819, encodeId=ec549108199f, content=good news and tool for AD, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Fri Dec 25 10:04:48 CST 2020, time=2020-12-25, status=1, ipAttribution=)]
    2020-12-25 rayms

    有意思

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1765128, encodeId=4f7a1e6512856, content=<a href='/topic/show?id=df00e086653' target=_blank style='color:#2F92EE;'>#病情#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70866, encryptionId=df00e086653, topicName=病情)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Oct 06 02:41:54 CST 2021, time=2021-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953950, encodeId=b6ea19539502a, content=<a href='/topic/show?id=88ece544685' target=_blank style='color:#2F92EE;'>#穿戴设备#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75446, encryptionId=88ece544685, topicName=穿戴设备)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, 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channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Dec 26 13:41:54 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910925, encodeId=9c139109257e, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Fri Dec 25 17:16:32 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910826, encodeId=0fbc910826bd, content=可穿戴设备会是一个热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/H3QXYibjbzM9C5GELMGhjqMatvmOsXy5gzoqIT6XJqYYCg7BqyfaLVW7gmk0bjAUJygFZUxt3XakaHUP7VIGDww/132, createdBy=a1285314326, createdName=taken110, createdTime=Fri Dec 25 10:37:24 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910823, encodeId=34949108237d, content=可穿戴设备帮助AD和PD患者缓解病情,这个真的很好!非侵入式而且还不用吃药。, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Dec 25 10:21:10 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910819, encodeId=ec549108199f, content=good news and tool for AD, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Fri Dec 25 10:04:48 CST 2020, time=2020-12-25, status=1, ipAttribution=)]
    2020-12-25 taken110

    可穿戴设备会是一个热点

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1765128, encodeId=4f7a1e6512856, content=<a href='/topic/show?id=df00e086653' target=_blank style='color:#2F92EE;'>#病情#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70866, encryptionId=df00e086653, topicName=病情)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Oct 06 02:41:54 CST 2021, time=2021-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953950, encodeId=b6ea19539502a, content=<a href='/topic/show?id=88ece544685' target=_blank style='color:#2F92EE;'>#穿戴设备#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75446, encryptionId=88ece544685, topicName=穿戴设备)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, createdName=apoenzyme, createdTime=Sun Jul 11 00:41:54 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878358, encodeId=7c2318e8358c6, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Fri Oct 08 01:41:54 CST 2021, time=2021-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1700695, encodeId=8f501e00695b9, content=<a href='/topic/show?id=82bc38512a4' target=_blank style='color:#2F92EE;'>#可穿戴设备#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38512, encryptionId=82bc38512a4, topicName=可穿戴设备)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=db8830213477, createdName=shalley76, createdTime=Sun Mar 07 08:41:54 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364679, encodeId=370d13646e936, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Sat Dec 26 13:41:54 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376224, encodeId=b53a13e6224f6, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Dec 26 13:41:54 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910925, encodeId=9c139109257e, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Fri Dec 25 17:16:32 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910826, encodeId=0fbc910826bd, content=可穿戴设备会是一个热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/H3QXYibjbzM9C5GELMGhjqMatvmOsXy5gzoqIT6XJqYYCg7BqyfaLVW7gmk0bjAUJygFZUxt3XakaHUP7VIGDww/132, createdBy=a1285314326, createdName=taken110, createdTime=Fri Dec 25 10:37:24 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910823, encodeId=34949108237d, content=可穿戴设备帮助AD和PD患者缓解病情,这个真的很好!非侵入式而且还不用吃药。, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Dec 25 10:21:10 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910819, encodeId=ec549108199f, content=good news and tool for AD, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Fri Dec 25 10:04:48 CST 2020, time=2020-12-25, status=1, ipAttribution=)]
    2020-12-25 Jessica

    可穿戴设备帮助AD和PD患者缓解病情,这个真的很好!非侵入式而且还不用吃药。

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1765128, encodeId=4f7a1e6512856, content=<a href='/topic/show?id=df00e086653' target=_blank style='color:#2F92EE;'>#病情#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70866, encryptionId=df00e086653, topicName=病情)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Oct 06 02:41:54 CST 2021, time=2021-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953950, encodeId=b6ea19539502a, content=<a href='/topic/show?id=88ece544685' target=_blank style='color:#2F92EE;'>#穿戴设备#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75446, encryptionId=88ece544685, topicName=穿戴设备)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, createdName=apoenzyme, createdTime=Sun Jul 11 00:41:54 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878358, encodeId=7c2318e8358c6, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Fri Oct 08 01:41:54 CST 2021, time=2021-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1700695, encodeId=8f501e00695b9, content=<a href='/topic/show?id=82bc38512a4' target=_blank style='color:#2F92EE;'>#可穿戴设备#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38512, 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channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Dec 26 13:41:54 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910925, encodeId=9c139109257e, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Fri Dec 25 17:16:32 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910826, encodeId=0fbc910826bd, content=可穿戴设备会是一个热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/H3QXYibjbzM9C5GELMGhjqMatvmOsXy5gzoqIT6XJqYYCg7BqyfaLVW7gmk0bjAUJygFZUxt3XakaHUP7VIGDww/132, createdBy=a1285314326, createdName=taken110, createdTime=Fri Dec 25 10:37:24 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910823, encodeId=34949108237d, content=可穿戴设备帮助AD和PD患者缓解病情,这个真的很好!非侵入式而且还不用吃药。, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Dec 25 10:21:10 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910819, encodeId=ec549108199f, content=good news and tool for AD, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Fri Dec 25 10:04:48 CST 2020, time=2020-12-25, status=1, ipAttribution=)]
    2020-12-25 神盾医疗局局长Jack

    good news and tool for AD

    0

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Nat Genet:阿尔茨海默症和帕金森病的单核苷酸多态性研究, 揭示两种疾病的遗传风险位点的变异

阿尔茨海默症(AD)和帕金森病(PD)是两种最常见的神经退行性疾病。尽管全基因组关联研究(GWAS)已确定了多个潜在的基因风险位点。然而大多数风险位点都位于非编码区。

JAMA Neurol :傻傻分不清楚……看起来是帕金森病,其实是罕见神经退行性疾病?

神经元核内包涵体病(NIID)是近年来新发现的一类罕见神经退行性疾病,有证据表明,NOTCH2NLC基因中GGC异常重复扩增与NIID有关,但目前尚无有效的治疗方法。

Brain:黄志力/王坚团队成功构建帕金森病快动眼睡眠期行为障碍动物模型

快动眼睡眠期行为障碍是帕金森病(Parkinson’s disease, PD)运动前驱期的重要生物学表型,可早期预测帕金森病的临床转归,从而成为帕金森病早期病程修饰的契机。

Lancet Neurology:用多个独立恒流控制装置刺激丘脑底核深部脑组织治疗帕金森病(INTREPID): 一项多中心、双盲、随机对照研究

帕金森病(PD)是一种常见的神经系统变性疾病,老年人多见。其病理改变是中脑黑质多巴胺(DA)能神经元的变性死亡,由此而引起纹状体DA含量显著性减少而致病。目前其确切病因尚不清楚。

Acta Neuropathologica: 大规模通路特异性多基因风险和转录组社区网络分析确定帕金森病的新功能途径

帕金森病(Parkinson's disease,PD)是一种常见的神经系统变性疾病,老年人多见,平均发病年龄为60岁左右。目前我国大部分帕金森病患者为散发病例,只有少数患者有家族史。