NEJM:HSV-1G207溶瘤病毒疗法治疗儿童高级别胶质瘤

2021-04-15 MedSci原创 MedSci原创

瘤内注射G207或联合放疗可显著缓解复发或进展型儿童高级别胶质瘤患者病情,且耐受性良好

高级别胶质瘤占儿童脑瘤的8%-10%,其恶性程度高,病情发展迅速,近日30年来,患者存活率无显著改善。目前临床上,接受标准放疗和化疗治疗的新发恶性高级胶质瘤患者的3年无事件生存率仅为11%-22%,复发患者的平均预期寿命仅5.6个月。儿童高级别胶质瘤在免疫上基本无响应,很少有肿瘤浸润淋巴细胞。溶瘤病毒治疗是一种很有前途的治疗癌症的新方法。它利用基因工程或天然病毒,在不伤害正常细胞的情况下选择性地复制并杀死癌细胞。临床前研究中,儿童脑肿瘤对基因工程单纯疱疹病毒1型(HSV-1)G207溶瘤病毒疗法高度敏感。

近日研究人员开展I期临床研究,评估了G207溶瘤病毒疗法的疗效及安全性。

本次研究采用3+3设计,经活检证实复发或进展型幕上脑肿瘤患儿参与。研究人员首先在患者脑部放置肿瘤内导管,随后第二天,患者接受了G207输注。第3组和第4组患者在G207给药后24小时内接受放疗(5Gy)。通过培养和聚合酶链反应分析对唾液、结膜和血液中的病毒脱落进行评估。通过免疫组织化学分析,检测治疗前后组织样本中肿瘤浸润的淋巴细胞。

12例高级别胶质瘤患者接受G207治疗,年龄范围7-18岁。未发现与G207治疗相关的剂量限制性毒性反应或严重不良事件。报告了20例1级不良事件,可能与G207治疗有关。未发现病毒脱落。11例患者出现影像学、神经病理学或临床缓解,患者平均总生存期为12.2个月。截至2020年6月5日,11名治疗应答患者中有4名,在治疗后18个月仍存活。G207能显著增加肿瘤浸润淋巴细胞的数量。

研究发现,瘤内注射G207或联合放疗可显著缓解复发或进展型儿童高级别胶质瘤患者病情,且耐受性良好

原始出处:

Gregory K. Friedman et al. Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas. N Engl J Med, April 10, 2021.

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    2022-01-02 gracezdd
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    2021-04-22 科研科研科研

    胶质瘤

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1987770, encodeId=2cbd198e770a9, content=<a href='/topic/show?id=34899169fe' target=_blank style='color:#2F92EE;'>#HSV-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9169, encryptionId=34899169fe, topicName=HSV-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Fri Jun 25 19:50:37 CST 2021, time=2021-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941650, encodeId=941c19416504c, content=<a href='/topic/show?id=48c291689e' target=_blank style='color:#2F92EE;'>#HSV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9168, encryptionId=48c291689e, topicName=HSV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Sun Jan 02 12:50:37 CST 2022, time=2022-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959482, encodeId=15be95948281, content=胶质瘤, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210110/e6124a4b19bc40ce8afaae096d21126b/dd778ac260c9416eb87e7d08139507f5.jpg, createdBy=4d2f5079605, createdName=科研科研科研, createdTime=Thu Apr 22 18:41:16 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035628, encodeId=b9f4103562874, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Apr 15 22:50:37 CST 2021, time=2021-04-15, status=1, ipAttribution=)]
    2021-04-15 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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