Ann Rheum Dis:巴瑞克替尼治疗活动性类风湿性关节炎的感染率

2020-08-18 xiangting MedSci原创

接受巴瑞克替尼治疗的类风湿性关节炎患者需要紧急治疗的感染发病率升高,其中包括带状疱疹。

巴瑞克替尼(Baricitinib)是一种每日口服一次的选择性、可逆性JAK1和JAK2抑制剂,目前临床用于多种炎症性疾病和自身免疫性疾病的治疗,包括类风湿性关节炎(RA)、强直性脊柱炎(AS)、银屑病、特应性皮炎、系统性红斑狼疮、溃疡性肠炎(UC)等。最近发表在风湿病学顶级期刊《Ann Rheum Dis》的一项研究评估了使用巴瑞克替尼治疗活动性类风湿性关节炎(RA)的感染发病率。

研究汇总了一个综合性数据库(包括8个3/2/1b临床试验和1个长期扩展试验(LTE))2017年4月1日以前的感染情况。“all-bari-RA”分析纳入所有接受过巴瑞克替尼治疗的患者。根据6项使用4mg巴瑞克替尼和安慰剂的研究(共24周)进行安慰剂比较,4项试验使用2mg巴瑞克替尼(安慰剂-对照组)。根据使用2mg和4mg巴瑞克替尼的4项研究进行剂量-反应评估,其中包括LTE数据(2-4mg)。

研究结果如下:3492例患者接受了巴瑞克替尼治疗,共计7860患者-年(PY)(中位时间2.6年,最长时间6.1年)。巴瑞克替尼组需要紧急治疗的感染发病率高于安慰剂(调整发病率(IR)/100 PY:安慰剂75.9、2mg 84.0(p不显著),4 mg 88.4(p≤0.001))。巴瑞克替尼组与安慰剂的严重感染发病率相似,并且随时间保持稳定(发病率3.0/100 PY)。其中结核11例(发病率0.1/100 PY),全部发生在使用4mg的流行区。巴瑞克替尼的带状疱疹(HZ)发病率高于安慰剂(安慰剂1.0/100 PY、2mg 3.1(无显著性),4mg 4.3(p≤0.01));发病率维持在较高水平,并随时间保持稳定(3.3)。包括多发性HZ在内的机会性感染在巴瑞克替尼试验中并不常见(0.5/100 PY)。

这项研究表明,接受巴瑞克替尼治疗的RA患者中需要紧急治疗的感染发病率升高,其中包括带状疱疹。这与巴瑞克替尼的免疫调节模式相符。

原始出处:

Kevin L Winthrop. Infections in baricitinib clinical trials for patients with active rheumatoid arthritis. Ann Rheum Dis. 11 August 2020.

 

 

 

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  4. [GetPortalCommentsPageByObjectIdResponse(id=1724005, encodeId=284e1e240053a, content=<a href='/topic/show?id=2d996516e7c' target=_blank style='color:#2F92EE;'>#活动性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65167, encryptionId=2d996516e7c, topicName=活动性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596833562866, createdName=楚秀娟, createdTime=Wed Dec 23 18:26:03 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013453, encodeId=0f1f201345317, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Aug 31 04:26:03 CST 2020, time=2020-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266228, encodeId=effe12662282f, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Aug 20 08:26:03 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1334259, encodeId=a7581334259e6, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Thu Aug 20 08:26:03 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483697, encodeId=74cd148369efa, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Thu Aug 20 08:26:03 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1486979, encodeId=f84e14869e93b, content=<a href='/topic/show?id=1bb94830504' target=_blank style='color:#2F92EE;'>#巴瑞克替尼#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48305, encryptionId=1bb94830504, topicName=巴瑞克替尼)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a6a68243754, createdName=fangcong, createdTime=Thu Aug 20 08:26:03 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810749, encodeId=b646810e4956, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25e55411955, createdName=ms5000000741733160, createdTime=Wed Aug 19 15:36:56 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810496, encodeId=cf8e81049639, content=<a href='/topic/show?id=7face61750b' target=_blank style='color:#2F92EE;'>#类风湿性关节炎#</a><a href='/topic/show?id=00664830602' target=_blank style='color:#2F92EE;'>#巴瑞替尼#</a>并不增加感染的机会风险以前的一些,你就认为JAk抑制剂可以增加感染,但是在真实世界人群中,其实差别并不大。, beContent=null, objectType=article, channel=null, level=null, likeNumber=204, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76175, encryptionId=7face61750b, topicName=类风湿性关节炎), TopicDto(id=48306, encryptionId=00664830602, topicName=巴瑞替尼)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Tue Aug 18 19:29:45 CST 2020, time=2020-08-18, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1724005, encodeId=284e1e240053a, content=<a href='/topic/show?id=2d996516e7c' target=_blank style='color:#2F92EE;'>#活动性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65167, encryptionId=2d996516e7c, topicName=活动性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596833562866, createdName=楚秀娟, createdTime=Wed Dec 23 18:26:03 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013453, encodeId=0f1f201345317, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Aug 31 04:26:03 CST 2020, time=2020-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266228, encodeId=effe12662282f, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Aug 20 08:26:03 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1334259, encodeId=a7581334259e6, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Thu Aug 20 08:26:03 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483697, encodeId=74cd148369efa, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Thu Aug 20 08:26:03 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1486979, encodeId=f84e14869e93b, content=<a href='/topic/show?id=1bb94830504' target=_blank style='color:#2F92EE;'>#巴瑞克替尼#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48305, encryptionId=1bb94830504, topicName=巴瑞克替尼)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a6a68243754, createdName=fangcong, createdTime=Thu Aug 20 08:26:03 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810749, encodeId=b646810e4956, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25e55411955, createdName=ms5000000741733160, createdTime=Wed Aug 19 15:36:56 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810496, encodeId=cf8e81049639, content=<a href='/topic/show?id=7face61750b' target=_blank style='color:#2F92EE;'>#类风湿性关节炎#</a><a href='/topic/show?id=00664830602' target=_blank style='color:#2F92EE;'>#巴瑞替尼#</a>并不增加感染的机会风险以前的一些,你就认为JAk抑制剂可以增加感染,但是在真实世界人群中,其实差别并不大。, beContent=null, objectType=article, channel=null, level=null, likeNumber=204, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76175, encryptionId=7face61750b, topicName=类风湿性关节炎), TopicDto(id=48306, encryptionId=00664830602, topicName=巴瑞替尼)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Tue Aug 18 19:29:45 CST 2020, time=2020-08-18, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1724005, encodeId=284e1e240053a, content=<a href='/topic/show?id=2d996516e7c' target=_blank style='color:#2F92EE;'>#活动性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65167, encryptionId=2d996516e7c, topicName=活动性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596833562866, createdName=楚秀娟, createdTime=Wed Dec 23 18:26:03 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013453, encodeId=0f1f201345317, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Aug 31 04:26:03 CST 2020, time=2020-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266228, encodeId=effe12662282f, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Aug 20 08:26:03 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1334259, encodeId=a7581334259e6, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Thu Aug 20 08:26:03 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483697, encodeId=74cd148369efa, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Thu Aug 20 08:26:03 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1486979, encodeId=f84e14869e93b, content=<a href='/topic/show?id=1bb94830504' target=_blank style='color:#2F92EE;'>#巴瑞克替尼#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48305, encryptionId=1bb94830504, topicName=巴瑞克替尼)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a6a68243754, createdName=fangcong, createdTime=Thu Aug 20 08:26:03 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810749, encodeId=b646810e4956, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25e55411955, createdName=ms5000000741733160, createdTime=Wed Aug 19 15:36:56 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810496, encodeId=cf8e81049639, content=<a href='/topic/show?id=7face61750b' target=_blank style='color:#2F92EE;'>#类风湿性关节炎#</a><a href='/topic/show?id=00664830602' target=_blank style='color:#2F92EE;'>#巴瑞替尼#</a>并不增加感染的机会风险以前的一些,你就认为JAk抑制剂可以增加感染,但是在真实世界人群中,其实差别并不大。, beContent=null, objectType=article, channel=null, level=null, likeNumber=204, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76175, encryptionId=7face61750b, topicName=类风湿性关节炎), TopicDto(id=48306, encryptionId=00664830602, topicName=巴瑞替尼)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Tue Aug 18 19:29:45 CST 2020, time=2020-08-18, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1724005, encodeId=284e1e240053a, content=<a href='/topic/show?id=2d996516e7c' target=_blank style='color:#2F92EE;'>#活动性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65167, encryptionId=2d996516e7c, topicName=活动性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596833562866, createdName=楚秀娟, createdTime=Wed Dec 23 18:26:03 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013453, encodeId=0f1f201345317, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Aug 31 04:26:03 CST 2020, time=2020-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266228, encodeId=effe12662282f, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Aug 20 08:26:03 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1334259, encodeId=a7581334259e6, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Thu Aug 20 08:26:03 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483697, encodeId=74cd148369efa, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Thu Aug 20 08:26:03 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1486979, encodeId=f84e14869e93b, content=<a href='/topic/show?id=1bb94830504' target=_blank style='color:#2F92EE;'>#巴瑞克替尼#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48305, encryptionId=1bb94830504, topicName=巴瑞克替尼)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a6a68243754, createdName=fangcong, createdTime=Thu Aug 20 08:26:03 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810749, encodeId=b646810e4956, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25e55411955, createdName=ms5000000741733160, createdTime=Wed Aug 19 15:36:56 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810496, encodeId=cf8e81049639, content=<a href='/topic/show?id=7face61750b' target=_blank style='color:#2F92EE;'>#类风湿性关节炎#</a><a href='/topic/show?id=00664830602' target=_blank style='color:#2F92EE;'>#巴瑞替尼#</a>并不增加感染的机会风险以前的一些,你就认为JAk抑制剂可以增加感染,但是在真实世界人群中,其实差别并不大。, beContent=null, objectType=article, channel=null, level=null, likeNumber=204, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76175, encryptionId=7face61750b, topicName=类风湿性关节炎), TopicDto(id=48306, encryptionId=00664830602, topicName=巴瑞替尼)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Tue Aug 18 19:29:45 CST 2020, time=2020-08-18, status=1, ipAttribution=)]
    2020-08-19 ms5000000741733160

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1724005, encodeId=284e1e240053a, content=<a href='/topic/show?id=2d996516e7c' target=_blank style='color:#2F92EE;'>#活动性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65167, encryptionId=2d996516e7c, topicName=活动性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596833562866, createdName=楚秀娟, createdTime=Wed Dec 23 18:26:03 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013453, encodeId=0f1f201345317, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Aug 31 04:26:03 CST 2020, time=2020-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266228, encodeId=effe12662282f, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Aug 20 08:26:03 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1334259, encodeId=a7581334259e6, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Thu Aug 20 08:26:03 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483697, encodeId=74cd148369efa, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Thu Aug 20 08:26:03 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1486979, encodeId=f84e14869e93b, content=<a href='/topic/show?id=1bb94830504' target=_blank style='color:#2F92EE;'>#巴瑞克替尼#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48305, encryptionId=1bb94830504, topicName=巴瑞克替尼)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a6a68243754, createdName=fangcong, createdTime=Thu Aug 20 08:26:03 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810749, encodeId=b646810e4956, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25e55411955, createdName=ms5000000741733160, createdTime=Wed Aug 19 15:36:56 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810496, encodeId=cf8e81049639, content=<a href='/topic/show?id=7face61750b' target=_blank style='color:#2F92EE;'>#类风湿性关节炎#</a><a href='/topic/show?id=00664830602' target=_blank style='color:#2F92EE;'>#巴瑞替尼#</a>并不增加感染的机会风险以前的一些,你就认为JAk抑制剂可以增加感染,但是在真实世界人群中,其实差别并不大。, beContent=null, objectType=article, channel=null, level=null, likeNumber=204, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76175, encryptionId=7face61750b, topicName=类风湿性关节炎), TopicDto(id=48306, encryptionId=00664830602, topicName=巴瑞替尼)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Tue Aug 18 19:29:45 CST 2020, time=2020-08-18, status=1, ipAttribution=)]
    2020-08-18 智慧医人

    #类风湿性关节炎##巴瑞替尼#并不增加感染的机会风险以前的一些,你就认为JAk抑制剂可以增加感染,但是在真实世界人群中,其实差别并不大。

    0

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