Am J Gastroenterol:奇异果、西梅干和李子也能治疗慢性便秘

2021-06-05 MedSci原创 MedSci原创

慢性便秘 (CC) 是一种常见的胃肠疾病 (GI) ,全球的患病率约为 7%–14%,每年约有近 400 万人次因便秘就诊。

慢性便秘 (CC) 是一种常见的胃肠疾病 (GI) ,全球的患病率约为 7%–14%,每年约有近 400 万人次因便秘就诊,根据罗马IV标准,CC 的范围包括功能性便秘 (FC) 和便秘型肠易激综合征 (IBS-C)。有许多非处方药和处方药可用于 FC 和 IBS-C的治疗。非处方产品,如纤维补充剂、渗透性泻药和兴奋剂,可以改善与肠道相关的不适,但对腹部症状几乎没有作用,在某些情况下还会加剧腹部症状。在美国,两种常用的 CC 自然食物是西梅干和李子干(李子)。西梅干是一种难发酵的纤维水果,具有保水和凝胶形成能力。李子含有纤维和山梨糖醇,通过多种机制增加粪便水分和体积,亚洲研究表明,奇异果也可能有益于 CC 症状的缓解。本项研究旨在通过前瞻性研究探究奇异果、西梅干和李子对于慢性便秘患者的治疗效果。

 

      研究人员对美国医疗中心患有 CC 的成年人进行 3 种自然食物的疗法。符合条件的患者每周≤3次完全自发排便 (CSBM),并部分随机分配至绿色奇异果 (2/d)、西梅 (100 g/d) 或车前子 (12 g/d) 治疗组,试验持续 4 周。主要观察终点是每组中在 4 个治疗周期后至少有 2 周与基线相比每周增加 ≥ 1 个 CSBM 的患者比例。次要观察结果包括大便频率、大便稠度和排便的用力情况。

 

      79 名 CC 患者(平均年龄 = 42.7 岁,87% 为女性,77% 为白人)被随机分组接受不同水果治疗。75 名患者(猕猴桃 29、李子 24 和车前子 22)的数据完整可用。对于主要观察终点,各个治疗组的 CSBM 应答者比例相似,所有患者的每周 CSBM 率均显着增加(P≤ 0.003);猕猴桃 ( P = 0.01) 和西梅 ( P = 0.049) 的粪便稠度显着改善;猕猴桃 ( P = 0.003)、李子 ( P < 0.001) 和西梅干 ( P= 0.04)腹胀评分显着改善。使用水果治疗后不良反应(AE) 最常见于西梅干,最不常见于猕猴桃。在治疗结束时,对猕猴桃不满意的患者比例较小(P = 0.02)。

图:不同水果对于便秘的缓解情况

      本项研究证实奇异果、李子和西梅可改善 CC 患者的便秘症状,便秘患者可以考虑在日常生活中增加这些水果的摄入量。

原始出处:

Chey, Samuel W. et al. Exploratory Comparative Effectiveness Trial of Green Kiwifruit, Psyllium, or Prunes in US Patients With Chronic Constipation. The American Journal of Gastroenterology.2021.

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    2021-12-03 ms7000000460666888

    奇异果,西梅干,李子干

    0

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    2022-02-26 许安
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    2021-09-02 ms4000001234997900

    奇异果是知道的,西梅和李子看来也可以多吃一些

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1076460, encodeId=a39610e646087, content=奇异果,西梅干,李子干, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/6b3242a7587647db8d80b25ab5c0938c/a2cd035c3b8d495683dd65e64c2d3d07.jpg, createdBy=b25f5704811, createdName=ms7000000460666888, createdTime=Fri Dec 03 08:33:30 CST 2021, time=2021-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712830, encodeId=4e991e1283089, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Mon Sep 20 04:22:22 CST 2021, time=2021-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2073360, encodeId=58bc20e336066, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sat Feb 26 13:22:22 CST 2022, time=2022-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1013813, encodeId=05ad101381334, content=奇异果是知道的,西梅和李子看来也可以多吃一些, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73685582088, createdName=ms4000001234997900, createdTime=Thu Sep 02 17:11:25 CST 2021, time=2021-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2065372, encodeId=e14120653e239, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Thu Jan 20 07:22:22 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971715, encodeId=810a9e171544, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=2a131713674, createdName=1deacbaem62(暂无匿称), createdTime=Tue Jun 08 08:33:21 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971163, encodeId=76489e11634f, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Jun 05 18:36:39 CST 2021, time=2021-06-05, status=1, ipAttribution=)]
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    2021-06-08 1deacbaem62(暂无匿称)

    学习了

    0

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    2021-06-05 医鸣惊人

    认真学习了

    0

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