Nat Commun:慢性阻塞性肺病患者相关肠道微生物组和代谢组分析

2020-11-29 xiaozeng MedSci原创

慢性阻塞性肺病(COPD)是一种异质性疾病,其具有肺部病理学症状,包括慢性支气管炎、气道重塑和肺气肿,会损害肺的功能。COPD也具有许多全身性并存症,如心血管疾病、结肠炎和骨质疏松症等。

慢性阻塞性肺病(COPD)是一种异质性疾病,其具有肺部病理学症状,包括慢性支气管炎、气道重塑和肺气肿,会损害肺的功能。COPD也具有许多全身性并存症,如血管疾病、结肠炎和骨质疏松症等。

作为全球第三大死亡原因,COPD的主要危险因素包括吸入香烟烟雾、污染空气以及其他有害颗粒。据报道,只有20–25%的吸烟者患上了COPD,尽管目前的研究已经发现了一些遗传风险因素,但如炎症和免疫反应在内其他因素也对贡献于该疾病的发病机理。


既往研究显示,肺部微生物组能够导致COPD的发生发展,但关于肠道微生物组的功能作用目前仍不清楚。

16S rRNA基因扩增测序区分COPD患者(28例)和健康个体(29例)的粪便微生物群

在该研究中,研究人员通过分析COPD患者和健康对照组的粪便微生物组和代谢组,发现两组之间有146种不同的细菌。而其中的一部分菌种,包括链球菌sp000187445、前庭链球菌以及链霉菌科的多个成员,均发现与肺功能下降有关。


研究人员通过非靶向代谢组学鉴定了COPD组的相关信息,包括46%脂质、20%异生物质和20%氨基酸相关代谢物。此外,研究人员阐述了一种疾病相关网络,将副链球菌B与COPD相关代谢物(包括N-乙酰谷氨酸及其类似物N-氨基甲酰基谷氨酸)关联在一起。

粪便微生物组和代谢组分析得到一个COPD相关网络

综上,该研究结果揭示了COPD患者的粪便微生物组和代谢组与健康个体的不同,该结果或有助于寻找COPD的潜在生物标志物。


原始出处:

Bowerman, K.L., Rehman, S.F., Vaughan, A. et al. Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease. Nat Commun 11, 5886 (18 November 2020).

 

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    2022-03-02 bai_yinge

    很好的文章

    0

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content=<a href='/topic/show?id=210553e077e' target=_blank style='color:#2F92EE;'>#慢性阻塞性肺病#</a> <a href='/topic/show?id=96ad3961325' target=_blank style='color:#2F92EE;'>#呼吸#</a> 研究结果揭示了COPD患者的粪便微生物组和代谢组与健康个体的不同,该结果或有助于寻找COPD的潜在生物标志物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53707, encryptionId=210553e077e, topicName=慢性阻塞性肺病), TopicDto(id=39613, encryptionId=96ad3961325, topicName=呼吸)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/a16c22989a2247c0a54b44d3e3acdaaa/44abb281938b4e04bc086f8345254626.jpg, createdBy=fb825296401, createdName=BJying, createdTime=Mon Nov 30 17:08:18 CST 2020, time=2020-11-30, status=1, ipAttribution=)]
    2021-04-09 liuli5079
  4. [GetPortalCommentsPageByObjectIdResponse(id=1198795, encodeId=04801198e954d, content=很好的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68244995880, createdName=bai_yinge, createdTime=Wed Mar 02 18:01:29 CST 2022, time=2022-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825226, encodeId=cbfb18252260e, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sat Jun 19 22:33:08 CST 2021, time=2021-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087845, encodeId=e1f1208e8457c, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Fri Apr 09 01:33:08 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696962, encodeId=96e5169696289, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Sun Jan 17 22:33:08 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1884828, encodeId=fe3e1884828b3, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue May 04 23:33:08 CST 2021, time=2021-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671959, encodeId=bdab16e1959cf, content=<a href='/topic/show?id=58378220131' target=_blank style='color:#2F92EE;'>#肺病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82201, encryptionId=58378220131, topicName=肺病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f0826868454, createdName=amy0559, createdTime=Wed Jul 07 11:33:08 CST 2021, time=2021-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382454, encodeId=8997138245498, content=<a href='/topic/show?id=49d350e1625' target=_blank style='color:#2F92EE;'>#微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50716, encryptionId=49d350e1625, topicName=微生物组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Tue Dec 01 08:33:08 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461632, encodeId=a11c146163258, content=<a href='/topic/show?id=7ccf816e335' target=_blank style='color:#2F92EE;'>#肠道微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81673, encryptionId=7ccf816e335, topicName=肠道微生物组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6316431503, createdName=snf701209, createdTime=Tue Dec 01 08:33:08 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480314, encodeId=f9ee14803146f, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Tue Dec 01 08:33:08 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903590, encodeId=ca5190359029, content=<a href='/topic/show?id=210553e077e' target=_blank style='color:#2F92EE;'>#慢性阻塞性肺病#</a> <a href='/topic/show?id=96ad3961325' target=_blank style='color:#2F92EE;'>#呼吸#</a> 研究结果揭示了COPD患者的粪便微生物组和代谢组与健康个体的不同,该结果或有助于寻找COPD的潜在生物标志物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53707, encryptionId=210553e077e, topicName=慢性阻塞性肺病), TopicDto(id=39613, encryptionId=96ad3961325, topicName=呼吸)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/a16c22989a2247c0a54b44d3e3acdaaa/44abb281938b4e04bc086f8345254626.jpg, createdBy=fb825296401, createdName=BJying, createdTime=Mon Nov 30 17:08:18 CST 2020, time=2020-11-30, status=1, ipAttribution=)]
    2021-01-17 tomyang96
  5. [GetPortalCommentsPageByObjectIdResponse(id=1198795, encodeId=04801198e954d, content=很好的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68244995880, createdName=bai_yinge, createdTime=Wed Mar 02 18:01:29 CST 2022, time=2022-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825226, encodeId=cbfb18252260e, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sat Jun 19 22:33:08 CST 2021, time=2021-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087845, encodeId=e1f1208e8457c, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Fri Apr 09 01:33:08 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696962, encodeId=96e5169696289, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Sun Jan 17 22:33:08 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1884828, encodeId=fe3e1884828b3, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue May 04 23:33:08 CST 2021, time=2021-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671959, encodeId=bdab16e1959cf, content=<a href='/topic/show?id=58378220131' target=_blank style='color:#2F92EE;'>#肺病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82201, encryptionId=58378220131, topicName=肺病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f0826868454, createdName=amy0559, createdTime=Wed Jul 07 11:33:08 CST 2021, time=2021-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382454, encodeId=8997138245498, content=<a href='/topic/show?id=49d350e1625' target=_blank style='color:#2F92EE;'>#微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50716, encryptionId=49d350e1625, topicName=微生物组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Tue Dec 01 08:33:08 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461632, encodeId=a11c146163258, content=<a href='/topic/show?id=7ccf816e335' target=_blank style='color:#2F92EE;'>#肠道微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81673, encryptionId=7ccf816e335, topicName=肠道微生物组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6316431503, createdName=snf701209, createdTime=Tue Dec 01 08:33:08 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480314, encodeId=f9ee14803146f, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Tue Dec 01 08:33:08 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903590, encodeId=ca5190359029, content=<a href='/topic/show?id=210553e077e' target=_blank style='color:#2F92EE;'>#慢性阻塞性肺病#</a> <a href='/topic/show?id=96ad3961325' target=_blank style='color:#2F92EE;'>#呼吸#</a> 研究结果揭示了COPD患者的粪便微生物组和代谢组与健康个体的不同,该结果或有助于寻找COPD的潜在生物标志物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53707, encryptionId=210553e077e, topicName=慢性阻塞性肺病), TopicDto(id=39613, encryptionId=96ad3961325, topicName=呼吸)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/a16c22989a2247c0a54b44d3e3acdaaa/44abb281938b4e04bc086f8345254626.jpg, createdBy=fb825296401, createdName=BJying, createdTime=Mon Nov 30 17:08:18 CST 2020, time=2020-11-30, status=1, ipAttribution=)]
    2021-05-04 liye789132251
  6. [GetPortalCommentsPageByObjectIdResponse(id=1198795, encodeId=04801198e954d, content=很好的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68244995880, createdName=bai_yinge, createdTime=Wed Mar 02 18:01:29 CST 2022, time=2022-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825226, encodeId=cbfb18252260e, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sat Jun 19 22:33:08 CST 2021, time=2021-06-19, status=1, ipAttribution=), 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createdName=tomyang96, createdTime=Sun Jan 17 22:33:08 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1884828, encodeId=fe3e1884828b3, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue May 04 23:33:08 CST 2021, time=2021-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671959, encodeId=bdab16e1959cf, content=<a href='/topic/show?id=58378220131' target=_blank style='color:#2F92EE;'>#肺病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82201, encryptionId=58378220131, topicName=肺病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f0826868454, createdName=amy0559, createdTime=Wed Jul 07 11:33:08 CST 2021, time=2021-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382454, encodeId=8997138245498, content=<a href='/topic/show?id=49d350e1625' target=_blank style='color:#2F92EE;'>#微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50716, encryptionId=49d350e1625, topicName=微生物组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Tue Dec 01 08:33:08 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461632, encodeId=a11c146163258, content=<a href='/topic/show?id=7ccf816e335' target=_blank style='color:#2F92EE;'>#肠道微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81673, encryptionId=7ccf816e335, topicName=肠道微生物组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6316431503, createdName=snf701209, createdTime=Tue Dec 01 08:33:08 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480314, encodeId=f9ee14803146f, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Tue Dec 01 08:33:08 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903590, encodeId=ca5190359029, content=<a href='/topic/show?id=210553e077e' target=_blank style='color:#2F92EE;'>#慢性阻塞性肺病#</a> <a href='/topic/show?id=96ad3961325' target=_blank style='color:#2F92EE;'>#呼吸#</a> 研究结果揭示了COPD患者的粪便微生物组和代谢组与健康个体的不同,该结果或有助于寻找COPD的潜在生物标志物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53707, encryptionId=210553e077e, topicName=慢性阻塞性肺病), TopicDto(id=39613, encryptionId=96ad3961325, topicName=呼吸)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/a16c22989a2247c0a54b44d3e3acdaaa/44abb281938b4e04bc086f8345254626.jpg, createdBy=fb825296401, createdName=BJying, createdTime=Mon Nov 30 17:08:18 CST 2020, time=2020-11-30, status=1, ipAttribution=)]
    2021-07-07 amy0559
  7. [GetPortalCommentsPageByObjectIdResponse(id=1198795, encodeId=04801198e954d, content=很好的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68244995880, createdName=bai_yinge, createdTime=Wed Mar 02 18:01:29 CST 2022, time=2022-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825226, encodeId=cbfb18252260e, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sat Jun 19 22:33:08 CST 2021, time=2021-06-19, status=1, ipAttribution=), 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createdName=tomyang96, createdTime=Sun Jan 17 22:33:08 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1884828, encodeId=fe3e1884828b3, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue May 04 23:33:08 CST 2021, time=2021-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671959, encodeId=bdab16e1959cf, content=<a href='/topic/show?id=58378220131' target=_blank style='color:#2F92EE;'>#肺病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82201, encryptionId=58378220131, topicName=肺病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f0826868454, createdName=amy0559, createdTime=Wed Jul 07 11:33:08 CST 2021, time=2021-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382454, encodeId=8997138245498, content=<a href='/topic/show?id=49d350e1625' target=_blank style='color:#2F92EE;'>#微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50716, encryptionId=49d350e1625, topicName=微生物组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Tue Dec 01 08:33:08 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461632, encodeId=a11c146163258, content=<a href='/topic/show?id=7ccf816e335' target=_blank style='color:#2F92EE;'>#肠道微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81673, encryptionId=7ccf816e335, topicName=肠道微生物组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6316431503, createdName=snf701209, createdTime=Tue Dec 01 08:33:08 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480314, encodeId=f9ee14803146f, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Tue Dec 01 08:33:08 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903590, encodeId=ca5190359029, content=<a href='/topic/show?id=210553e077e' target=_blank style='color:#2F92EE;'>#慢性阻塞性肺病#</a> <a href='/topic/show?id=96ad3961325' target=_blank style='color:#2F92EE;'>#呼吸#</a> 研究结果揭示了COPD患者的粪便微生物组和代谢组与健康个体的不同,该结果或有助于寻找COPD的潜在生物标志物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53707, encryptionId=210553e077e, topicName=慢性阻塞性肺病), TopicDto(id=39613, encryptionId=96ad3961325, topicName=呼吸)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/a16c22989a2247c0a54b44d3e3acdaaa/44abb281938b4e04bc086f8345254626.jpg, createdBy=fb825296401, createdName=BJying, createdTime=Mon Nov 30 17:08:18 CST 2020, time=2020-11-30, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1198795, encodeId=04801198e954d, content=很好的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68244995880, createdName=bai_yinge, createdTime=Wed Mar 02 18:01:29 CST 2022, time=2022-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825226, encodeId=cbfb18252260e, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sat Jun 19 22:33:08 CST 2021, time=2021-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087845, encodeId=e1f1208e8457c, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Fri Apr 09 01:33:08 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696962, encodeId=96e5169696289, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Sun Jan 17 22:33:08 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1884828, encodeId=fe3e1884828b3, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue May 04 23:33:08 CST 2021, time=2021-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671959, encodeId=bdab16e1959cf, content=<a href='/topic/show?id=58378220131' target=_blank style='color:#2F92EE;'>#肺病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82201, encryptionId=58378220131, topicName=肺病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f0826868454, createdName=amy0559, createdTime=Wed Jul 07 11:33:08 CST 2021, time=2021-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382454, encodeId=8997138245498, content=<a href='/topic/show?id=49d350e1625' target=_blank style='color:#2F92EE;'>#微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50716, encryptionId=49d350e1625, topicName=微生物组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Tue Dec 01 08:33:08 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461632, encodeId=a11c146163258, content=<a href='/topic/show?id=7ccf816e335' target=_blank style='color:#2F92EE;'>#肠道微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81673, encryptionId=7ccf816e335, topicName=肠道微生物组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6316431503, createdName=snf701209, createdTime=Tue Dec 01 08:33:08 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480314, encodeId=f9ee14803146f, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Tue Dec 01 08:33:08 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903590, encodeId=ca5190359029, content=<a href='/topic/show?id=210553e077e' target=_blank style='color:#2F92EE;'>#慢性阻塞性肺病#</a> <a href='/topic/show?id=96ad3961325' target=_blank style='color:#2F92EE;'>#呼吸#</a> 研究结果揭示了COPD患者的粪便微生物组和代谢组与健康个体的不同,该结果或有助于寻找COPD的潜在生物标志物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53707, encryptionId=210553e077e, topicName=慢性阻塞性肺病), TopicDto(id=39613, encryptionId=96ad3961325, topicName=呼吸)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/a16c22989a2247c0a54b44d3e3acdaaa/44abb281938b4e04bc086f8345254626.jpg, createdBy=fb825296401, createdName=BJying, createdTime=Mon Nov 30 17:08:18 CST 2020, time=2020-11-30, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1198795, encodeId=04801198e954d, content=很好的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68244995880, createdName=bai_yinge, createdTime=Wed Mar 02 18:01:29 CST 2022, time=2022-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825226, encodeId=cbfb18252260e, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sat Jun 19 22:33:08 CST 2021, time=2021-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087845, encodeId=e1f1208e8457c, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Fri Apr 09 01:33:08 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696962, encodeId=96e5169696289, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, 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encryptionId=58378220131, topicName=肺病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f0826868454, createdName=amy0559, createdTime=Wed Jul 07 11:33:08 CST 2021, time=2021-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382454, encodeId=8997138245498, content=<a href='/topic/show?id=49d350e1625' target=_blank style='color:#2F92EE;'>#微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50716, encryptionId=49d350e1625, topicName=微生物组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Tue Dec 01 08:33:08 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461632, encodeId=a11c146163258, content=<a href='/topic/show?id=7ccf816e335' target=_blank style='color:#2F92EE;'>#肠道微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81673, encryptionId=7ccf816e335, topicName=肠道微生物组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6316431503, createdName=snf701209, createdTime=Tue Dec 01 08:33:08 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480314, encodeId=f9ee14803146f, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Tue Dec 01 08:33:08 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903590, encodeId=ca5190359029, content=<a href='/topic/show?id=210553e077e' target=_blank style='color:#2F92EE;'>#慢性阻塞性肺病#</a> <a href='/topic/show?id=96ad3961325' target=_blank style='color:#2F92EE;'>#呼吸#</a> 研究结果揭示了COPD患者的粪便微生物组和代谢组与健康个体的不同,该结果或有助于寻找COPD的潜在生物标志物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53707, encryptionId=210553e077e, topicName=慢性阻塞性肺病), TopicDto(id=39613, encryptionId=96ad3961325, topicName=呼吸)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/a16c22989a2247c0a54b44d3e3acdaaa/44abb281938b4e04bc086f8345254626.jpg, createdBy=fb825296401, createdName=BJying, createdTime=Mon Nov 30 17:08:18 CST 2020, time=2020-11-30, status=1, ipAttribution=)]
  10. 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encryptionId=58378220131, topicName=肺病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f0826868454, createdName=amy0559, createdTime=Wed Jul 07 11:33:08 CST 2021, time=2021-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382454, encodeId=8997138245498, content=<a href='/topic/show?id=49d350e1625' target=_blank style='color:#2F92EE;'>#微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50716, encryptionId=49d350e1625, topicName=微生物组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Tue Dec 01 08:33:08 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461632, encodeId=a11c146163258, content=<a href='/topic/show?id=7ccf816e335' target=_blank style='color:#2F92EE;'>#肠道微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81673, encryptionId=7ccf816e335, topicName=肠道微生物组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6316431503, createdName=snf701209, createdTime=Tue Dec 01 08:33:08 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480314, encodeId=f9ee14803146f, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Tue Dec 01 08:33:08 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903590, encodeId=ca5190359029, content=<a href='/topic/show?id=210553e077e' target=_blank style='color:#2F92EE;'>#慢性阻塞性肺病#</a> <a href='/topic/show?id=96ad3961325' target=_blank style='color:#2F92EE;'>#呼吸#</a> 研究结果揭示了COPD患者的粪便微生物组和代谢组与健康个体的不同,该结果或有助于寻找COPD的潜在生物标志物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53707, encryptionId=210553e077e, topicName=慢性阻塞性肺病), TopicDto(id=39613, encryptionId=96ad3961325, topicName=呼吸)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/a16c22989a2247c0a54b44d3e3acdaaa/44abb281938b4e04bc086f8345254626.jpg, createdBy=fb825296401, createdName=BJying, createdTime=Mon Nov 30 17:08:18 CST 2020, time=2020-11-30, status=1, ipAttribution=)]
    2020-11-30 BJying

    #慢性阻塞性肺病# #呼吸# 研究结果揭示了COPD患者的粪便微生物组和代谢组与健康个体的不同,该结果或有助于寻找COPD的潜在生物标志物。

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