Diabetes Care减肥是否成功主要靠脑:糖尿病患者通过低热量饮食和胃旁路手术减肥会导致不同的大脑激活模式

2021-06-27 MedSci原创 MedSci原创

与通过限制卡路里减肥的人相比,接受减肥手术的人在食欲大脑处理方面经历了三种互补的变化。这些大脑对不同减肥方法的不同反应可能解释了为什么在完成短期VLCD后有重获体重的趋势。

肥胖和2型糖尿病(T2D)是我们这个时代最大的全球健康挑战之一。卫生系统正在大量投资于以人口为基础的减肥策略,关于实现健康长期改善的最有效方法的辩论仍在进行。通过极低热量饮食(VLCD)实现的体重减轻可以缓解T2D,在有动机的参与者中持续2年。然而,在人群水平上,实现长期减肥的生活方式干预措施并不普遍成功,有人认为,严重的热量限制会导致激素和代谢反应,从而导致体重的高恢复率。只有减肥手术被证明能产生持久的体重减轻,转化为糖尿病的长期改善甚至缓解,以及心血管和癌症相关死亡率的风险降低。减肥手术产生代谢益处的机制仍不完全清楚,但手术后食物偏好和饥饿感的变化经常被报道,并可能发挥作用。功能磁共振成像(fMRI)提供了一个机会,研究神经通路,支持不同的减肥方法。 Diabetes Care杂志最近发表研究文章,该研究假设在肥胖和糖尿病前期/T2D患者中,用fMRI测量的对食物线索反应的大脑活动纵向变化可以解释这种差异。 根据以前的文献,该团队确定了不同的纵向变化,大脑活动分为三个情况。1、RYGB诱导大脑奖赏中心食物线索反应性降低,这是单独限制卡路里摄入所没有的。2、与认知控制或“理性”决策相

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    2021-11-30 Clinician-X

    学习到了👍🏻

    0

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  5. 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  6. 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  7. 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  8. 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  9. 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  10. 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    2021-06-27 misszhang

    谢谢MedSci提供最新的资讯

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