BMJ Open:水凝胶敷料作为急救手段辅助治疗小儿急性烧伤的有效性:一项前瞻性的随机对照试验

2021-09-26 MedSci原创 MedSci原创

近日,发表于BMJ Open的一项单中心、优越性、双臂、平行组、前瞻性随机对照试验比较了两种急性烧伤敷料在降低小儿烧伤患者适当急救后的急性疼痛评分方面的效

近日,发表于BMJ Open的一项单中心、优越性、双臂、平行组、前瞻性随机对照试验比较了两种急性烧伤敷料(Burnaid水凝胶敷料和塑化聚氯乙烯薄膜)在降低小儿烧伤患者适当急救后的急性疼痛评分方面的效果。

2017年9月-2018年9月,研究纳入在澳大利亚布里斯班昆士兰儿童医院急诊科就诊的急性热烧伤的儿科患者(年龄≤16岁)。患者随机接受(1)Burnaid水凝胶敷料(干预)或(2)塑化聚氯乙烯薄膜(对照)作为急性烧伤敷料。敷料后5分钟进行的观察性疼痛评分。在后续更换敷料时也收集了疼痛、压力和重新上皮化的重复测量,直到95%的伤口重新上皮化。

 

研究共招募了72名儿童并进行了随机分组(37名干预组;35名对照组)。护理人员(平均差异:-0.1,95%CI-0.7至0.5,P=0.72)或照顾者(MD:1,95%CI-8至11,P=0.78)的观察疼痛评分没有显著的组间差异。此外,两组之间儿童自我报告的疼痛(MD:0.3,95% CI -1.7至2.2,p=0.78)、心率(MD:-3,95% CI -11至5,p=0.41)、体温(MD:0.6,95% CI -0. 13至0.24,p=0.53),压力(几何平均比值:1.53,95%CI 0.93至2.53,p=0.10),和重新上皮率(MD:-1,95%CI -3至1,p=0.26)没有显著差异。

综上,该研究结果表明,在这项调查中,没有发现Burnaid水凝胶敷料作为急救措施的镇痛辅助手段对治疗小儿急性烧伤有明显的益处。

原始出处:

Maleea Denise Holbert, et al., Effectiveness of a hydrogel dressing as an analgesic adjunct to first aid for the treatment of acute paediatric burn injuries: a prospective randomised controlled trial. BMJ Open. 2021 Jan 5;11(1):e039981. doi: 10.1136/bmjopen-2020-039981.

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time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055049, encodeId=99381055049bc, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sun Sep 26 17:52:51 CST 2021, time=2021-09-26, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1729127, encodeId=9a361e2912753, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Apr 20 06:55:59 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775589, encodeId=a2091e7558997, content=<a href='/topic/show?id=937d46650bf' target=_blank style='color:#2F92EE;'>#对照#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46650, encryptionId=937d46650bf, topicName=对照)], attachment=null, authenticateStatus=null, createdAvatar=null, 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href='/topic/show?id=edd364149bc' target=_blank style='color:#2F92EE;'>#水凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64149, encryptionId=edd364149bc, topicName=水凝胶)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Tue Sep 28 07:55:59 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461083, encodeId=5542146108308, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Tue Sep 28 07:55:59 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055049, encodeId=99381055049bc, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sun Sep 26 17:52:51 CST 2021, time=2021-09-26, status=1, ipAttribution=)]
    2021-10-24 guozhenyu
  6. 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time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055049, encodeId=99381055049bc, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sun Sep 26 17:52:51 CST 2021, time=2021-09-26, status=1, ipAttribution=)]
    2022-01-13 gaoxiaoe
  7. 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  8. 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time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055049, encodeId=99381055049bc, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sun Sep 26 17:52:51 CST 2021, time=2021-09-26, status=1, ipAttribution=)]
    2021-09-28 tastas
  9. 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    2021-09-28 lishizhe
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time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055049, encodeId=99381055049bc, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sun Sep 26 17:52:51 CST 2021, time=2021-09-26, status=1, ipAttribution=)]
    2021-09-26 医鸣惊人

    认真学习了

    0

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2020年7月16日,国际疼痛学会对"疼痛" 定义进行了修改,并在线发表在其会刊《PAIN》杂志上。这是IASP对自1979年开始在全世界使用的疼痛定义的首次修订。

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对于脊柱转移瘤患者,立体定向放疗(24 Gy)在提高疼痛的完全缓解率方面优于常规外照射放疗(20 Gy)