JCEM:青春期抗穆勒氏管激素水平与多囊卵巢综合征的关系

2020-12-23 MedSci原创 MedSci原创

青春期测量的抗穆勒氏管激素(AMH)作为预测成人多囊卵巢综合征(PCOS)的生物标记物尚未得到证实。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinolog

青春期测量的抗穆勒氏管激素(AMH)作为预测成人多囊卵巢综合征(PCOS)的生物标记物尚未得到证实。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在调查青春期血清AMH水平和其他PCOS相关特征是否可以预测成人PCOS。

在1990年至1997年之间进行的一项青少年月经不调研究的基础上,研究人员进行了一项长期随访研究,对271名少女检测了AMH水平。有关PCOS功能的数据与AMH水平结合在一起。在初始研究后的二十年中,研究人员对271名参与者中的160人(59%)通过问卷收集了有关其月经周期和PCOS的情况。

与正常月经周期的女孩相比,月经过少的少女AMH水平更高,AMH水平中位数(IQR):4.6(3.1-7.5) vs. 2.6(1.7-3.8)μg/L(P<0.001)。与成年期PCOS的女性青少年AMH中位数更高,为6.0,相比于非PCOS组青少年AMH为2.5μg/L,(P<0.001)。青春期AMH对于成年期PCOS的ROC曲线下面积为0.78。在月经过少的青春期女孩中,成年期发展为PCOS的比例为22.5%(95%CI为12.4-37.4%),而在正常月经周期的女孩中为5.1%(95%CI为2.1-12.0%)(P=0.005)。考虑到青春期的月经过少,将高AMH水平作为成人PCOS或月经过少的预测因素没有任何价值。

由此可见,青春期AMH不能单独或联合其它指标作为成年PCOS的预测指标。因此,并不建议在临床实践对其进行常规检测。

原始出处:

Mirte R Caanen.et al.Anti-Müllerian hormone levels in adolescence in relation to long-term follow-up for presence of polycystic ovary syndrome.JCEM.2020.https://doi.org/10.1210/clinem/dgaa949

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encodeId=6ed9910565aa, content=青春期抗穆勒氏管激素水平与多囊卵巢综合征的关系,这种研究我孤陋寡闻了。原来年少时的我。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Thu Dec 24 09:58:36 CST 2020, time=2020-12-24, status=1, ipAttribution=)]
    2021-05-02 achengzhao
  5. 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encodeId=6ed9910565aa, content=青春期抗穆勒氏管激素水平与多囊卵巢综合征的关系,这种研究我孤陋寡闻了。原来年少时的我。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Thu Dec 24 09:58:36 CST 2020, time=2020-12-24, status=1, ipAttribution=)]
    2021-02-01 12522d9cm81暂无昵称

    学习了

    0

  6. 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encodeId=6ed9910565aa, content=青春期抗穆勒氏管激素水平与多囊卵巢综合征的关系,这种研究我孤陋寡闻了。原来年少时的我。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Thu Dec 24 09:58:36 CST 2020, time=2020-12-24, status=1, ipAttribution=)]
    2020-12-30 124764c3m24(暂无昵称)

    优秀

    0

  7. 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    2020-12-26 ms7878997314608653

    学习了

    0

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    2020-12-24 Jessie Zhang

    青春期抗穆勒氏管激素水平与多囊卵巢综合征的关系,这种研究我孤陋寡闻了。原来年少时的我。。。。

    0

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J Clin Endocrinol Metab:西他列汀可降低多囊卵巢综合征妇女的内脏脂肪和血糖水平

多囊卵巢综合症(PCOS)的女性生长激素(GH)减少,可导致内脏脂肪(VAT)增加和血管功能受损。GH释放激素是一种二肽基肽酶-4(DPP4)底物,可刺激GH分泌。我们测试了DPP4抑制能增加GH并改

Complement Ther Med:S.officinalis提取物可预防多囊卵巢综合征患者的胰岛素抵抗

本研究为一项随机、三盲、对照试验,旨在评估丹参(S.officinalis)提取物对多囊卵巢综合征(PCOS)患者 "人体测量指数 "和 "胰岛素抵抗标志物 "的影响。

Eur J Endocrinol:PCOS女性行为矫正干预可提高患者的心理幸福感,并有助于减肥

目前尚未清楚生活方式如何影响多囊卵巢综合征(PCOS)超重妇女的心理健康。本研究旨在了解行为矫正对心理幸福感的影响,以及幸福感和人格特征对成功减肥的影响,研究结果已在线发表于Eur J Endocri

Biol Trace Elem Res:铬联合肉碱可改善超重和肥胖多囊卵巢综合征女性的体重和代谢指标

本研究旨在确定服用铬加肉碱对胰岛素抵抗的影响,次要目标是评估对多囊卵巢综合征(PCOS)超重受试者的血脂谱和体重减轻的影响。