NCB:新方法助科学家了解细胞癌变进程

2012-01-22 MedSci MedSci原创

近日,国际著名杂志《自然—化学生物学》Nature Chemical Biology杂志在线刊登了德国研究人员的最新研究成果“Natural product–inspired cascade synthesis yields modulators of centrosome integrity,”,文章中,研究者开发出了一种能够有效合成仿天然分子的方法,利用该方法合成的分子具有控制细胞有丝分裂的作

近日,国际著名杂志《自然—化学生物学》Nature Chemical Biology杂志在线刊登了德国研究人员的最新研究成果“Natural product–inspired cascade synthesis yields modulators of centrosome integrity,”,文章中,研究者开发出了一种能够有效合成仿天然分子的方法,利用该方法合成的分子具有控制细胞有丝分裂的作用,这有助于科学家了解细胞常规功能以及癌症的变化。

受到吲哚类生物碱这种天然物结构的启发,Kamal Kumar,Herbert Waldmann和其他研究人员发明的合成方法可在“一锅法”中产生12种不同反应,其合成的高复杂多环化合物可在分子6处位置发生结构变化。

研究人员将合成得到的26种分子进行测试,看是否能对细胞产生效果。结果发现,和吲哚类生物碱一样,这些分子确实对有丝分裂产生了影响。目前已知核仁磷酸蛋白与癌症发生有关,但其具体作用却仍是未知,这些分子也许能为我们了解核仁磷酸蛋白在正常细胞与染病细胞中的功能提供有价值的帮助。(生物谷Bioon.com)

Natural product–inspired cascade synthesis yields modulators of centrosome integrity

Heiko Dückert, Verena Pries, Vivek Khedkar, Sascha Menninger, Hanna Bruss, Alexander W Bird, Zoltan Maliga, Andreas Brockmeyer, Petra Janning, Anthony Hyman, Stefan Grimme, Markus Schürmann, Hans Preut, Katja Hübel, Slava Ziegler, Kamal Kumar & Herbert Waldmann

In biology-oriented synthesis, the scaffolds of biologically relevant compound classes inspire the synthesis of focused compound collections enriched in bioactivity. This criterion is, in particular, met by the scaffolds of natural products selected in evolution. The synthesis of natural product–inspired compound collections calls for efficient reaction sequences that preferably combine multiple individual transformations in one operation. Here we report the development of a one-pot, twelve-step cascade reaction sequence that includes nine different reactions and two opposing kinds of organocatalysis. The cascade sequence proceeds within 10–30 min and transforms readily available substrates into complex indoloquinolizines that resemble the core tetracyclic scaffold of numerous polycyclic indole alkaloids. Biological investigation of a corresponding focused compound collection revealed modulators of centrosome integrity, termed centrocountins, which caused fragmented and supernumerary centrosomes, chromosome congression defects, multipolar mitotic spindles, acentrosomal spindle poles and multipolar cell division by targeting the centrosome-associated proteins nucleophosmin and Crm1.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1978305, encodeId=0bee19e8305cf, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue Aug 14 09:47:00 CST 2012, time=2012-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1903003, encodeId=5024190300342, content=<a href='/topic/show?id=e1b0583884b' target=_blank style='color:#2F92EE;'>#新方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58388, encryptionId=e1b0583884b, topicName=新方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c22f171, createdName=kord1982, createdTime=Fri Aug 10 11:47:00 CST 2012, time=2012-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1557011, encodeId=4098155e011b8, content=<a href='/topic/show?id=154be128170' target=_blank style='color:#2F92EE;'>#癌变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71281, encryptionId=154be128170, topicName=癌变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd7914850828, createdName=axin014, createdTime=Tue Jan 24 11:47:00 CST 2012, time=2012-01-24, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1978305, encodeId=0bee19e8305cf, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue Aug 14 09:47:00 CST 2012, time=2012-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1903003, encodeId=5024190300342, content=<a href='/topic/show?id=e1b0583884b' target=_blank style='color:#2F92EE;'>#新方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58388, encryptionId=e1b0583884b, topicName=新方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c22f171, createdName=kord1982, createdTime=Fri Aug 10 11:47:00 CST 2012, time=2012-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1557011, encodeId=4098155e011b8, content=<a href='/topic/show?id=154be128170' target=_blank style='color:#2F92EE;'>#癌变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71281, encryptionId=154be128170, topicName=癌变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd7914850828, createdName=axin014, createdTime=Tue Jan 24 11:47:00 CST 2012, time=2012-01-24, status=1, ipAttribution=)]
    2012-08-10 kord1982
  3. [GetPortalCommentsPageByObjectIdResponse(id=1978305, encodeId=0bee19e8305cf, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue Aug 14 09:47:00 CST 2012, time=2012-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1903003, encodeId=5024190300342, content=<a href='/topic/show?id=e1b0583884b' target=_blank style='color:#2F92EE;'>#新方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58388, encryptionId=e1b0583884b, topicName=新方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c22f171, createdName=kord1982, createdTime=Fri Aug 10 11:47:00 CST 2012, time=2012-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1557011, encodeId=4098155e011b8, content=<a href='/topic/show?id=154be128170' target=_blank style='color:#2F92EE;'>#癌变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71281, encryptionId=154be128170, topicName=癌变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd7914850828, createdName=axin014, createdTime=Tue Jan 24 11:47:00 CST 2012, time=2012-01-24, status=1, ipAttribution=)]
    2012-01-24 axin014

相关资讯

Mol. Cell:启动癌细胞对糖嗜好的丙酮酸脱氢酶激酶或为抗癌靶标

癌细胞对糖的渴望,部分上是因为它们关闭它们的线粒体——能够有效燃烧葡萄糖的动力厂——以便偏好一种更加无效率的方式使用葡萄糖。它们获益,因为副产物能够为快速生长的癌细胞提供构建材料。 美国埃默里大学温希普癌症研究所科学家证实很多类型的癌细胞扳动开关让葡萄糖从线粒体转移走。他们的发现提示着促进几种类型癌症生长的酪氨酸激酶在线粒体中发挥的作用要比人们以前所认识的大得多。 这些结果也突出地显示丙酮

PNAS:c-Myc-SIRT1通道是癌细胞无限分裂的分子机制

近日,国际著名杂志PNAS刊登了德国慕尼黑大学等机构的研究人员的最新研究成果“The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop。”,文章中,研究人员揭示了癌细胞无限分裂的一种分子机制。 癌细胞最显著

Science:皮肤中的免疫细胞可产生化学物质促发癌症

在这个表皮表层里,可见朗格汉斯细胞(绿色)构成一个细胞网络,延长树突状的进程 日前,刊登在最新一期Science上的一篇论文"Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma"表明,以能探测到皮肤中的外来入侵物而闻名的一组免疫细胞也能通过代谢环境中的化学物质而促进肿瘤的生长。 包括皮肤及

JCO:临终关怀不能降低患者的化疗等级

(图片来源:Medpage Today) 麻省总医院的Joseph Greer博士等近日在《临床肿瘤学杂志》(Journal of Clinical Oncology)发表论文称,对已有转移的非小细胞肺癌患者早期开展临终关怀并不能降低患者的化疗等级。但这些患者在其生命的最后60天内都不大可能接受化疗,尤其是静脉治疗,而且这些患者更希望自己的最后时光在临终关怀医院度过。 之前有报道称,在标准肿瘤

Cancer Cell:VCAM-1可能是癌症转移关键因子

近日,国际癌症研究权威刊物《癌细胞》Cancer Cell刊登了来自普林斯顿大学分子生物学系,山东大学齐鲁医院等处的研究人员的最新研究成果“VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progen

2011年中国肿瘤学领域关键进展汇总

 本文主要介绍2011年中国在肿瘤病学方面的重大科研项目成果,并进行汇总。前面以临床研究为主,后面一部分以基础研究为主,全面介绍中国在肿瘤领域的重大进展,也代表了中国临床和科研工作者在一年来的主要成就。   中国胸部肿瘤协作组成绩斐然 OPTIMAL研究正式发表   同济大学附属上海市肺科医院 周彩存   中国胸部肿瘤协作组(CTONG)自2007年成立以来,在国际肺癌领域取得