Front Cell Infect Microbiol:牙龈卟啉单胞菌感染会增加类风湿性关节炎的发病风险

2022-08-15 MedSci原创 MedSci原创

类风湿性关节炎(RA)是一种系统性的自身免疫疾病,以慢性滑膜关节炎症为特征。当宿主的致病性清除机制紊乱时,牙龈卟啉单胞菌(P. gingivalis)感染可在人类中引起危及生命的炎症免疫反应。

类风湿性关节炎(RA)是一种系统性的自身免疫疾病,以慢性滑膜关节炎症为特征。当宿主的致病菌清除机制紊乱时,牙龈卟啉单胞菌(P. gingivalis)感染可引起危及生命的炎症性免疫反应。一些流行病学研究报告显示,牙龈卟啉单胞菌感染会增加RA的发病率。然而,各研究的结果并不一致。近日,发表于Front Cell Infect Microbiol的一项荟萃分析系统地分析了龈卟啉单胞菌暴露与类风湿性关节炎患病率之间的关系。

研究人员检索了包括Cochrane图书馆、Web of Science、PubMed和EMBASE在内的数据库,以寻找已发表的流行病学文章,评估牙龈卟啉单胞菌和RA之间的关系。根据预定的纳入和排除标准对检索到的研究进行筛选。通过STATA 15.1软件的随机效应模型,对纳入的文章的ORs进行汇总分析。

结果,文献检索共发现2057项研究,排除不符合的文献后,最后纳入28篇文章进行分析。汇总的ORs显示,暴露于牙龈卟啉单胞菌的个体患RA的风险明显增加(OR=1.86;95%CI:1.43-2.43)。亚组分析显示,来自欧洲(OR=2.17;95%CI:1.46-3.22)和北美(OR=2.50;95%CI:1.23-5.08)人群的集合OR值明显高于亚洲人群(OR=1.11;95%CI:1.03-1.20)。虽然观察到这些研究存在大量的异质性,但并不明显影响总体结果。

综上所述,该研究结果表明,牙龈卟啉单胞菌感染是RA的一个风险因素。及时诊断牙龈卟啉单胞菌的感染,并及时进行抗菌治疗和制定管理决策将有助于防止类风湿性关节炎的发展和恶化。

 

原始出处:

Yilin Li, et al., The Relationship Between Porphyromonas Gingivalis and Rheumatoid Arthritis: A Meta-Analysis. Front Cell Infect Microbiol. 2022 Jul 18;12:956417.  doi: 10.3389/fcimb.2022.956417. eCollection 2022.

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    2023-03-29 维他命
  4. [GetPortalCommentsPageByObjectIdResponse(id=1767923, encodeId=fbc61e6792391, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Fri Nov 18 06:50:27 CST 2022, time=2022-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1858062, encodeId=213018580625e, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun May 28 10:50:27 CST 2023, time=2023-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962819, encodeId=6bc1196281943, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Mar 29 15:50:27 CST 2023, time=2023-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1919480, encodeId=e9431919480af, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Dec 17 06:50:27 CST 2022, time=2022-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084747, encodeId=52252084e47c6, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Wed Mar 22 13:50:27 CST 2023, time=2023-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872490, encodeId=409418e2490d8, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, 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target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Tue Aug 16 12:50:27 CST 2022, time=2022-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361086, encodeId=dac01361086bd, content=<a href='/topic/show?id=c1006e72663' target=_blank style='color:#2F92EE;'>#牙龈卟啉单胞菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67726, encryptionId=c1006e72663, topicName=牙龈卟啉单胞菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7a159, createdName=3631173, createdTime=Tue Aug 16 12:50:27 CST 2022, time=2022-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483775, encodeId=2d9d1483e75d3, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Tue Aug 16 12:50:27 CST 2022, time=2022-08-16, status=1, ipAttribution=)]
    2022-12-17 sunylz
  5. [GetPortalCommentsPageByObjectIdResponse(id=1767923, encodeId=fbc61e6792391, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Fri Nov 18 06:50:27 CST 2022, time=2022-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1858062, encodeId=213018580625e, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, 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encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Dec 17 06:50:27 CST 2022, time=2022-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084747, encodeId=52252084e47c6, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Wed Mar 22 13:50:27 CST 2023, time=2023-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872490, encodeId=409418e2490d8, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, 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target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Tue Aug 16 12:50:27 CST 2022, time=2022-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361086, encodeId=dac01361086bd, content=<a href='/topic/show?id=c1006e72663' target=_blank style='color:#2F92EE;'>#牙龈卟啉单胞菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67726, encryptionId=c1006e72663, topicName=牙龈卟啉单胞菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7a159, createdName=3631173, createdTime=Tue Aug 16 12:50:27 CST 2022, time=2022-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483775, encodeId=2d9d1483e75d3, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Tue Aug 16 12:50:27 CST 2022, time=2022-08-16, status=1, ipAttribution=)]
    2023-03-22 xjy02
  6. [GetPortalCommentsPageByObjectIdResponse(id=1767923, encodeId=fbc61e6792391, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Fri Nov 18 06:50:27 CST 2022, time=2022-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1858062, encodeId=213018580625e, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, 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  7. 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    2022-08-16 lmm397
  8. 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  9. 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IgG抗瓜氨酸蛋白抗体可变域糖基化(IgG ACPA VDG)的丰度随着类风湿性关节炎(RA)发作而增加,并与ACPA反应的成熟度相关。RA发病时VDG水平较低与长期无药物缓解(DFR)相关。

A&R:类风湿性关节炎成纤维细胞样滑膜细胞营养转运蛋白的表观遗传调控

该研究结果表明,基因表观遗传的变化与营养转运蛋白有关,代谢途径可用于识别类风湿性关节炎(RA)特异性靶标,包括关键的溶质载体转运蛋白、酶和转录因子,以开发新的治疗药物。

羟氯喹在风湿科临床应用

HCQ在系统性红斑狼疮(SLE)、类风湿性关节炎(RA)等疾病应用现状。

弄懂这四点,与风湿性关节炎划清“三八线”

风湿性关节炎与类风湿性关节炎鉴别。

ARD:HLA-DR天然呈递肽的分离鉴定出了类风湿性关节炎的T细胞表位

该研究在生理相关背景下显著扩展了HLA-DR分子呈现的肽库,鉴定了RA患者的 CD4 + T细胞识别的六个新表位。这些信息对于更好地了解疾病免疫病理学以及设计耐受抗原特异性免疫疗法非常重要。

ARD: 间充质细胞激活素A的缺失可改善实验性关节炎的疾病严重程度

成纤维细胞样滑膜细胞(FLS)产生的激活素A在炎症性关节破坏中起着至关重要的旁分泌作用,并且可能是治疗与 破骨细胞形成和骨破坏相关的炎症性疾病(如类风湿性关节炎)的潜在靶点。