SCI REP:H型高血压与无症状性颅外动脉狭窄之间的相关性分析!

2018-01-22 xing.T MedSci原创

该研究结果为H型高血压在ECAS发生中的重要性提供了直接的证据,其是颈动脉粥样硬化的一个潜在的治疗靶点。

无症状性颅外动脉狭窄(ECAS)是卒中和H型高血压危险因素之一,H型高血压定义为高血压合并高同型半胱氨酸血症,其与心脑血管疾病相关。然而,H型高血压对ECAS的影响仍是未知的。近日,Scientific reports 杂志上发表了一篇研究文章,该研究的目的是探讨H型高血压与ECAS患病率之间的关联。

在这项研究中,研究人员纳入了2330名参与者,分为四组:无高血压或高同型半胱氨酸血症对照组、单纯高血压组、单纯高同型半胱氨酸血症组和H型高血压组。研究人员测量了基线血浆总同型半胱氨酸水平,并且采用颈动脉超声评估了基线和随访期间的ECAS。研究人员使用Cox回归模型分析了H型高血压与ECAS之间的关系。

在基线时,608例受试者患有H型高血压。在2年的随访期间,250名(10.73%)参与者发生无症状的ECAS。对相关风险因素进行调整后,研究人员发现H型高血压是无症状ECAS的独立危险因素(相对危险度(RR)为3.16,95%可信区间(95%CI)为2-5)。

由此可见,该研究结果为H型高血压在ECAS发生中的重要性提供了直接的证据,其是颈动脉粥样硬化的一个潜在的治疗靶点。

原始出处:


Jia Zhang,et al. Association between H-type Hypertension and Asymptomatic Extracranial Artery Stenosis.Scientific reports. 2018. https://www.nature.com/articles/s41598-018-19740-0

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