JAHA:急性心肌梗塞患者发生早期复发性心肌梗塞的特征和结局

2021-08-02 MedSci原创 MedSci原创

早期RMI是一种危及生命的疾病,5年内死亡率接近50%。支架相关事件和冠状动脉疾病进展是大多数早期RMI的原因。药物依从性、积极的危险因素管理和治疗过渡应该是预防早期RMI的基石。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在了解急性心肌梗死后出院90天内因复发性心肌梗死(RMI)再次入院患者的特征和结局。

研究人员分析了2010年1月1日至2017年1月1日期间急性心肌梗死后90天内因早期RMI入院的所有患者再梗死的时间、病因和结局。研究人员共确定了6626例急性心肌梗死住院患者,其中在出院90天内发生了168例RMI。

患者的平均年龄为65.1±13.1岁,37%为女性。早期RMI的90天再入院率为2.5%。黑人、医疗管理、较高的肌钙蛋白T水平和较短的住院时间是早期RMI的独立预测因素。

早期复发性心肌梗塞患者的结局

与经皮冠状动脉介入治疗(P=0.04)或冠状动脉旁路移植术(P=0.2)相比,药物治疗组发生早期RMI的风险更高。再梗死的主要机制是支架内血栓形成(17%)、疾病进展(12%)和病情未发生改变的冠状动脉疾病(11%)。5年时,早期RMI患者的全因死亡率为49%(95%CI为40%-57%),而无早期RMI患者的全因死亡率为22%(95%CI为21%-23%)(P<0.0001)。

由此可见,早期RMI是一种危及生命的疾病,5年内死亡率接近50%。支架相关事件和冠状动脉疾病进展是大多数早期RMI的原因。药物依从性、积极的危险因素管理和治疗过渡应该是预防早期RMI的基石。

原始出处:

Raunak Nair.et al.Characteristics and Outcomes of Early Recurrent Myocardial Infarction After Acute Myocardial Infarction.JAHA.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.019270

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    2021-08-04 zhaohui6731
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    2021-08-02 DIfh

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