Lancet Child Adol Health:小儿严重烧伤与心脏功能障碍

2017-10-23 zhangfan MedSci原创

严重的小儿烧伤对青春期后期心脏功能产生持久的影响,并与心肌纤维化和运动耐量降低有关,导致患儿成年后心力衰竭等相关的发病率和死亡率风险增加

败血症、创伤和严重烧伤可降低心脏收缩和舒张功能。近日研究人员评估了小儿严重烧伤对心脏长期收缩和舒张功能、心肌纤维化和运动耐量的影响。

研究人员对研究开始至少5年前,烧伤面积30%以上患儿的资料进行收集,同时招募年龄相匹的健康对照组。所有参与者接受超声心动图来量化左室收缩功能(射血分数)、舒张功能(E/e')和心肌纤维化评估,通过休息和高峰运动时耗氧量(VO2)和心率进行定量运动耐量评估。人口学资料、临床资料和生物标志物的表达被用来预测长期心脏功能障碍和纤维化。

研究招募65名参与者,其中烧伤患者40人,健康对照25人。烧伤患儿的平均年龄19岁,烧伤发生平均年龄12岁,平均烧伤面积59%。研究发现,烧伤患儿射血分数降低(52% vs 61%)、舒张功能受损(E/e' 9.8vs 5.4)、耐力降低(VO2 峰值 38 mL/min/kg vs 46 mL/min/kg)、峰值心率降低 (161 vs 182 bpm)。烧伤患儿中,有11人存在中度收缩功能障碍 (29%) ,6人存在重度收缩功能障碍,19人存在中度舒张障碍,8人存在重度舒张障碍,7人存在心肌纤维化。

严重的小儿烧伤对青春期后期心脏功能产生持久的影响,并与心肌纤维化和运动耐量降低有关,导致患儿成年后心力衰竭等相关的发病率和死亡率风险增加。

原始出处:


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    2018-07-25 howi
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    2018-05-25 docwu2019
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    2018-01-18 shizhenshan
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1783125, encodeId=48c51e8312540, content=<a href='/topic/show?id=855a464292' target=_blank style='color:#2F92EE;'>#child#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4642, encryptionId=855a464292, topicName=child)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ebc122, createdName=yankaienglish, createdTime=Sat Sep 08 07:24:00 CST 2018, time=2018-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1829269, encodeId=4b58182926909, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Wed Jul 25 12:24:00 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661967, encodeId=6972166196e88, content=<a href='/topic/show?id=260c9e210e' target=_blank style='color:#2F92EE;'>#ILD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9721, encryptionId=260c9e210e, topicName=ILD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Fri May 25 02:24:00 CST 2018, time=2018-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1861165, encodeId=13b1186116532, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Thu Jan 18 17:24:00 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2037013, encodeId=82bb203e013a7, content=<a href='/topic/show?id=7f015144617' target=_blank style='color:#2F92EE;'>#心脏功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51446, encryptionId=7f015144617, topicName=心脏功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b3e473, createdName=pyaili, createdTime=Sat Sep 22 21:24:00 CST 2018, time=2018-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413771, encodeId=31fe1413e716c, content=<a href='/topic/show?id=3a96514459f' target=_blank style='color:#2F92EE;'>#心脏功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51445, encryptionId=3a96514459f, topicName=心脏功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a293020977, createdName=tidiq, createdTime=Wed Oct 25 04:24:00 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421106, encodeId=c3601421106a2, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Wed Oct 25 04:24:00 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621674, encodeId=017516216e45a, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Wed Oct 25 04:24:00 CST 2017, time=2017-10-25, status=1, ipAttribution=)]
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